Strategy and tactics of patients’ treatment with complicated forms of atopic dermatitis

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Atopic dermatitis (AD) is a chronic, recurrent skin disease caused by disruption of the skin barrier, IgE-mediated hypersensitivity to environmental factors, and immune imbalance. The issues of the etiology and pathogenesis of AD where the leading and predisposing role are played by the features of the skin barrier are considered. These processes lead to a change in the skin microbiome and the triggering of the cytokine and chemokine reactions of innate immunity with the involvement of the immune system cells. It was shown that the microbial flora of the skin in a significant part of patients with allergic dermatoses causes complications during disease. The data of foreign and Russian studies on the pathogenesis and treatment of AD are presented. The main directions in the treatment of AD are highlighted based on international and Russian clinical guidelines. The place of topical combined drugs in the treatment of complicated forms of AD and dermatoses of combined etiology was determined. The advantages of micronized drugs have been substantiated: high therapeutic efficacy and low risk of the undesirable phenomena formation. The efficacy and safety of the topical preparation betamethasone (micronized) + gentamicin + clotrimazole cream has been shown in the wide practice of a dermatovenerologist. Based on data from foreign and Russian studies it has been shown that the use of the combined drug betamethasone (micronized) + gentamicin + clotrimazole in the treatment of complicated forms of AD is effective and safe and meets the requirements of modern principles and standards of treatment.

Keywords:

atopic dermatitis

pathogenesis

therapy

topical corticosteroids

combination therapy

betamethasone + gentamicin + clotrimazole cream

Authors:

Matushevskaya E.V.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA

ORCID: 0000-0003-4583-0617

Svirshchevskaya E.V.

Shemyakin-Ovchinnikov Institute of bioorganic chemistry RAS

Received:

20.05.2021

Accepted:

11.06.2021

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