The analysis of the results of 11 genome-wide studies of atopic dermatitis (AD) by various research teams, which revealed more than 100 GWAS-significant polymorphic loci involved in the formation of the disease, is presented. It should be noted that, firstly, all these studies of AD were carried out abroad on samples from various foreign populations. Samples from Russian populations were not included in these studies; therefore, it can be stated that to date, genome-wide studies of AD in Russian populations have not been carried out. Second, only a small number of GWAS-significant polymorphic loci for AD are replicated in different populations at the genome-wide level. Third, it is noteworthy that with an increase in the sample size of patients and control persons included in genome-wide studies, and, as a rule, each subsequent genome-wide study is performed on a larger sample than the previous one, the number of GWAS-significant loci will increase... Fourth, an important contribution to the formation of susceptibility to the development of AD, according to genome-wide studies, is made by mutations in the filaggrin gene, not only associated with loss-of-function variants (for example, rs61816761 — R501X), but also by polymorphic loci in this gene (synonymous mutations) that are not associated with amino acid substitutions in the filaggrin protein and, accordingly, do not initially lead to a violation of its function.