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Perlamutrov Iu.N.

GBOU VPO "Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova"

Starshinina V.A.

GBOU VPO «Moskovskij gosudarstvennyj mediko-stomatologicheskij universitet im. A.I. Evdokimova» Minzdrava Rossii, Moskva, Rossija, 127473

Ol'khovskaia K.B.

Moscow State Medico-Stomatological University, Moscow

Analysis of immunohistochemical data in the case of lichen ruber planus of the oral mucosa with underlying human papillomavirus infection (in Russian only)

Authors:

Perlamutrov Iu.N., Starshinina V.A., Ol'khovskaia K.B.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2018;17(6): 46‑52

DOI: 10.17116/klinderma20181706146

Read: 1639 times

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Table of contents

ANALYSIS OF IMMUNOHISTOCHEMICAL DATA IN THE CASE OF LICHEN RUBER PLANUS OF THE ORAL MUCOSA WITH UNDERLYING HUMAN PAPILLOMAVIRUS INFECTION (IN RUSSIAN ONLY)
ANALYSIS OF IMMUNOHISTOCHEMICAL DATA IN THE CASE OF LICHEN RUBER PLANUS OF THE ORAL MUCOSA WITH UNDERLYING HUMAN PAPILLOMAVIRUS INFECTION (IN RUSSIAN ONLY)

To cite this article:

Perlamutrov IuN, Starshinina VA, Ol'khovskaia KB. Analysis of immunohistochemical data in the case of lichen ruber planus of the oral mucosa with underlying human papillomavirus infection (in Russian only). Russian Journal of Clinical Dermatology and Venereology. 2018;17(6):46‑52. (In Russ.)
https://doi.org/10.17116/klinderma20181706146

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Decreased general immunity and local resistance in patients with lichen ruber planus (LRP) of the oral mucosa (OM) provides a relatively favorable environment for chronic human papillomavirus infection, which is an exogenous factor causing structural reorganization of tissues. Objective — the study was aimed at comparing the proliferative activity of epithelial cells in terms of expression of Ki-67 antigen in patients with erosive-ulcerative form of LRP with identified and unidentified human papillomavirus infection (HPV). Material and methods. We examined 48 patients with erosive-ulcerative form of LRP of the OM with a disease duration from 6 months to 9 years. HPV infection was verified and severity of the underlying disease was determined; an immunohistochemical study was performed to determine the Ki-67 antigen. Results. The frequency of detection of proliferative activity factor Ki-67 is closely related to involvement of human papillomavirus in the process. Characteristic features of the course of LRP in patients with diagnosed HPV were determined, including mostly severe form and the early onset of dermatosis in the majority of study group patients.

Keywords:

lichen ruber planus
oral mucosa
human papillomavirus infection
immunohistochemistry
proliferation markers
Ki-67

Authors:

Perlamutrov Iu.N.

GBOU VPO "Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova"

Starshinina V.A.

GBOU VPO «Moskovskij gosudarstvennyj mediko-stomatologicheskij universitet im. A.I. Evdokimova» Minzdrava Rossii, Moskva, Rossija, 127473

Ol'khovskaia K.B.

Moscow State Medico-Stomatological University, Moscow

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References:

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