Men who have sex with men (MSM) form a high risk group for STI and HIV infection. According to the results of international studies, most new cases of primary syphilis, gonorrhea, and chlamydia infection occur in MSM. However, there are no official data on the prevalence of sexually transmitted infections among MSM in Russia. There are no practical recommendations on dermatovenereological examination of this category of patients with allowance for the characteristic features of their sexual behavior and localization of infectious process. There is insufficient interaction between doctors of related specialties, in particular between dermatovenereologists and coloproctologists and vice versa, which leads to the further spread of STIs due to erroneous tactics of examination and treatment of patients. Objective. The study was aimed at characterization of MSM in Moscow as a special social group that requires regular medical, preventive, and counseling services and assessing the incidence of bacterial and viral STIs: Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, Herpes simplex virus (HSV) I, HSV II and Treponema pallidum. Material and methods. We examined 93 MSM who visited a coloproctologist. Each respondent underwent a questionnaire survey to obtain information about the social status, sex life, chronic diseases, etc. The following biomaterials were examined: mucosal discharge of the oropharynx and rectum and the first portion of urine. The laboratory study for the presence of infectious agents was carried out by PCR using the AmpliSens N. gonorrhoeae/C. trachomatis/M. genitalium/T. vaginalis-MULTIPRIME-FL and AmpliSens HSVII/HSVI/T. pallidum-MULTIPRIME-FL reagent kits. Results. We found an extremely high prevalence of STIs among men who have sex with men and who visited proctology clinics in Moscow. This category of patients is first of all characterized by extragenital localization of the infectious process. Forty seven patients (50.5%) were infected with at least one of the aforementioned STIs. N. gonorrhoeae and C. trachomatis (19.4% and 16.1%, respectively) and HSV I, II were the most common infections. A high proportion of patients with early forms of syphilis (6.5%) was detected among the examined individuals. Conclusion. High STI infection rates and extragenital localization necessitate improvement of clinical and laboratory examination tactics for MSM and well-coordinated interdisciplinary interaction between coloproctologists and dermatovenereologists.