The general issues of the history of sexually transmitted diseases in the Perm province in the late 18^th and in the 19^th centuries are covered based on unpublished works of the State Archive of the Sverdlovsk Region and publications released during the studied historical period. Sexually transmitted diseases were called the French pox, white, yellow or red hernia, cutter in substandard language, as well as in early medical documents. Mercury salts, namely cinnabar and mercuric chloride, were used to treat these diseases both in academic and traditional medicine which often led to death because of their toxicity. Traditional practioners also used phytotherapeutic means — decoctions and poultices from various plants to relieve the sufferings of diseased. There were fantastic explanations of contamination in public mind («micturate against the wind», et-c.) in addition to realistic understanding of transmission mechanism of sexually transmitted diseases. There were medium rates of sexually transmitted diseases in Perm province compared to other Russian districts, at the same time the number of infected people could be significant in some districts (especially in northern) and in individual villages.