To date, there are almost no methods to predict the course of atopic dermatitis (AtD) and assess the risk of its recurrence. Objective — the research was aimed at calculating the ratio of serum levels of α2-macroglobulin, lactoferrin, and α1-antitrypsin in patients with various forms and severity of atopic dermatitis, determining its importance in prediction of the further course of the disease, and assessment of treatment efficacy. Material and methods. We analyzed blood samples from adult patients with acute AtD (mild, moderate, severe, IgE-associated, and IgE-independent forms), as well as after the course of treatment (only conventional or supplemented by immunosuppressive sodium salt of gamma-D-glutamyl-D-tryptophan). Coefficient K = α2-MG (g/l) × α1-AT (g/l) × LF (mg/l) was calculated based on the results of sample analysis using ELISA and quantitative immunoelectrophoresis followed by calculation of its average values for each group using the InStat-II software. Results. The coefficient normally did not exceed 6 points and increased with increase in the severity of AtD. In the case of mild to moderate AtD, there was no significant correlation between the form of the disease and the coefficient; it averaged 21 points in patients with severe AtD and IgE-associated form and more than 35 points in patients with IgE-independent form. Conventional treatment partially reduced the coefficient in the case of IgE-dependent AtD and had almost no effect in the case of the independent form. Administration of the immunosuppressor enhanced the effectiveness of conventional therapy in the case of IgE-dependent AtD by reducing the ratio (mostly due to the level of lactoferrin). Conclusion. AtD has a systemic impact on blood proteins, the ratio of their concentrations can be used to quantify the severity and treatment efficacy. The lack of complete normalization of the ratio of the immunomodulatory proteins during treatment contributes to AtD recurrence and can be used to predict the duration of remission.