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Sokolova T.V.

State Institute of Advanced Medical Training, Russian Ministry of Defense

Rassel K.

Institute of medico-social technologies of Moscow State University of Food Production, 125080, Moscow, Russia

The development of a rational approach to the therapy of fungal skin infections as the basis of effective treatment

Authors:

Sokolova T.V., Rassel K.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2018;17(2): 17‑26

DOI: 10.17116/klinderma201817217-26

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To cite this article:

Sokolova TV, Rassel K. The development of a rational approach to the therapy of fungal skin infections as the basis of effective treatment. Russian Journal of Clinical Dermatology and Venereology. 2018;17(2):17‑26. (In Russ.)
https://doi.org/10.17116/klinderma201817217-26

 
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The paper presents a literature review focusing on the comparative analysis of the efficacy and safety of topical antifungals of various pharmaceutical groups. We used data from 74 publications of international and Russian authors when preparing this article, including the results of author’s own long-term studies. It was shown that sertaconazole is a highly active antifungal with a broad-spectrum fungicidal, antibacterial, anti-inflammatory activity and antipruritic effect. The spectrum of the specific activity of the drug enables its application in all nosological forms of fungal skin infections. High efficacy of sertaconazole in treatment of fungal skin infections was proved by numerous Russian and international clinical trials, and therefore the drug can be included in the group of the first-line topical antifungals. The results of the comparative analysis of the efficacy of sertaconazole with that of terbinafine and clotrimazole demonstrated the superiority of the former. Sertaconazole is superior to other topical antimycotic imidazoles in treatment of dermatophytes, as evidenced by in vitro experiments. It kills 86.7% of fungal strains with minimal resistance (4%). Activity of sertaconazole against skin mycosis caused by Candida spp. yeast-like fungi is 10.8-fold higher compared to that of terbinafine and 47.9-fold higher compared to that of naftifine. The evidence-based information on the safety of the drug suggests that sertaconazole can be used in children over 1 year old.

Keywords:

sertaconazole
efficacy
resistance
advantages

Authors:

Sokolova T.V.

State Institute of Advanced Medical Training, Russian Ministry of Defense

Rassel K.

Institute of medico-social technologies of Moscow State University of Food Production, 125080, Moscow, Russia

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