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Voronina O.L.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Ryzhova N.N.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Kunda M.S.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Ermolova E.I.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Goncharova E.R.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology;
I.M. Sechenov First Moscow State Medical University

Samarina M.S.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology;
I.M. Sechenov First Moscow State Medical University

Kustova M.A.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology;
I.M. Sechenov First Moscow State Medical University

Karpova T.I.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Klimova E.A.

Russian University of Medicine

Melkumyan A.R.

National Medical Research Center of Coloproctology named after A.N. Ryzhikh;
Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department

Tartakovsky I.S.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Dynamics of the spectrum of genotypes of Listeria monocytogenes, which caused invasive listeriosis during the period of circulation of sars-cov-2 Omicron variants

Authors:

Voronina O.L., Ryzhova N.N., Kunda M.S., Ermolova E.I., Goncharova E.R., Samarina M.S., Kustova M.A., Karpova T.I., Klimova E.A., Melkumyan A.R., Tartakovsky I.S.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2024;42(3): 29‑36

DOI: 10.17116/molgen20244203129

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Table of contents

DYNAMICS OF THE SPECTRUM OF GENOTYPES OF LISTERIA MONOCYTOGENES, WHICH CAUSED INVASIVE LISTERIOSIS DURING THE PERIOD OF CIRCULATION OF SARS-COV-2 OMICRON VARIANTS
DYNAMICS OF THE SPECTRUM OF GENOTYPES OF LISTERIA MONOCYTOGENES, WHICH CAUSED INVASIVE LISTERIOSIS DURING THE PERIOD OF CIRCULATION OF SARS-COV-2 OMICRON VARIANTS

To cite this article:

Voronina OL, Ryzhova NN, Kunda MS, et al. . Dynamics of the spectrum of genotypes of Listeria monocytogenes, which caused invasive listeriosis during the period of circulation of sars-cov-2 Omicron variants. Molecular Genetics, Microbiology and Virology. 2024;42(3):29‑36. (In Russ.)
https://doi.org/10.17116/molgen20244203129

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Invasive listeriosis (IL) is a disease caused by Listeria monocytogenes due to consumption of contaminated food. Immunosuppression, which is one of the reasons for susceptibility to infection in risk groups, can be increased due to a viral illness. In the early years of the COVID-19 pandemic, changes occurred both in the performance of the sample of patients with IL in the meningitis-septicemia (MS) cohort and in the genomic characteristics of L. monocytogenes that caused the disease.

THE PURPOSE OF THE STUDY

To continue monitoring IL in the Moscow region, compare samples of patients with IL and clinical isolates of L. monocytogenes isolated in 2022 with a high incidence of COVID-19 and in 2023—04.2024 with a decrease in the incidence of this infection.

MATHERIAL AND METHODS

Clinical isolates isolated from Moscow hospital patients diagnosed with IL with manifestations of MS were studied using multilocus and whole-genome sequencing methods, followed by bioinformatic analysis. The parameters of the patient groups were compared based on epicrisis data.

RESULTS

Comparison of subgroups of patients with IL showed that the “2022” subgroup had a higher proportion of male patients, patients diagnosed with COVID-19, pneumonia/pulmonary fibrosis, and a higher incidence of deaths. In the subgroup “2023—04.2024” there was a higher proportion of patients with cancer and a higher variety of previous or concomitant viral infections.

Clinical isolates of L. monocytogenes were represented by 19 genotypes, 5 of which belonged to phylogenetic lineage I (PLI). In the period 2023—04.2024, the genetic characteristics of the pathogen of IL in the Moscow region continued to change. The diversity of PLII isolates has increased, the proportion of PLI isolates has decreased, which, as before the pandemic, are represented by L. monocytogenes of two serogroups: 4b and 1/2b.

CONCLUSION

The noted changes in the spectrum of IL pathogen genotypes are not only a consequence of the impact of the COVID-19 pandemic on the health of the population, but also trends in the food industry.

Keywords:

Listeria monocytogenes
invasive listeriosis
SARS-CoV-2 Omicron
Influenza
MLST
WGS
virulence factors
resistance
epidemic clones (EC)

Authors:

Voronina O.L.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Ryzhova N.N.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Kunda M.S.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Ermolova E.I.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Goncharova E.R.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology;
I.M. Sechenov First Moscow State Medical University

Samarina M.S.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology;
I.M. Sechenov First Moscow State Medical University

Kustova M.A.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology;
I.M. Sechenov First Moscow State Medical University

Karpova T.I.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Klimova E.A.

Russian University of Medicine

Melkumyan A.R.

National Medical Research Center of Coloproctology named after A.N. Ryzhikh;
Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department

Tartakovsky I.S.

N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Received:

18.06.2024

Accepted:

17.07.2024

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