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Matushevskaia E.V.

FGOU Institut povysheniia kvalifikatsii Federal'nogo mediko-biologicheskogo agentstva RF, Moskva

Svirshchevskaia E.V.

Institut bioorganicheskoĭ khimii im. M.M. Shemiakina i Iu.A. Ovchinnikova RAN, Moskva, 117997, Rossiĭskaia Federatsiia

Drug micronization technique: new possibilities of topical corticosteroids in dermatology

Authors:

Matushevskaia E.V., Svirshchevskaia E.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2017;16(1): 43‑48

DOI: 10.17116/klinderma201716143-48

Read: 6437 times

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Table of contents

DRUG MICRONIZATION TECHNIQUE: NEW POSSIBILITIES OF TOPICAL CORTICOSTEROIDS IN DERMATOLOGY
DRUG MICRONIZATION TECHNIQUE: NEW POSSIBILITIES OF TOPICAL CORTICOSTEROIDS IN DERMATOLOGY

To cite this article:

Matushevskaia EV, Svirshchevskaia EV. Drug micronization technique: new possibilities of topical corticosteroids in dermatology. Russian Journal of Clinical Dermatology and Venereology. 2017;16(1):43‑48. (In Russ.)
https://doi.org/10.17116/klinderma201716143-48

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The development of nanotechnology provided technical capability to obtain a number of poorly soluble drugs in micronized and nanonized form, which increases their bioavailability and improves efficacy. Chemical, physical, and biological properties of micronized and nanonized agents significantly differ from those of the starting material. In pharmacology, nanoparticles and microparticles are most often used to improve their bioavailability in the case of topical, intranasal, intraocular, and rectal administration. The review provides the results of Russian and international clinical research on various types of micronization and nanonization, as well as the study of the efficacy and safety of micronized drugs in medicine and dermatology. We report the data demonstrating increased bioavailability of glucocorticosteroids (GCSs), when using micronization. The advantages of micronized GCS preparations Komfoderm (Komfoderm, Komfoderm M2, Komfoderm K) and coformulated drugs Akriderm SK and Akriderm GK in the treatment of steroid-responsive dermatoses have been shown.

Keywords:

steroids
micronization
micronized drugs
coformulated drugs
benefits
Komfoderm
Komfoderm M2
Komfoderm K
Akriderm SK
Akriderm GK
efficacy
safety

Authors:

Matushevskaia E.V.

FGOU Institut povysheniia kvalifikatsii Federal'nogo mediko-biologicheskogo agentstva RF, Moskva

Svirshchevskaia E.V.

Institut bioorganicheskoĭ khimii im. M.M. Shemiakina i Iu.A. Ovchinnikova RAN, Moskva, 117997, Rossiĭskaia Federatsiia

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