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Davidenko E.B.

Moskovskiĭ nauchno-prakticheskiĭ tsentr dermatovenerologii i kosmetologii;
Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Makhneva N.V.

Moskovskiĭ nauchno-prakticheskiĭ tsentr dermatovenerologii i kosmetologii Departamenta zdravookhraneniia

Beletskaia L.V.

FGU "Federal'nyĭ nauchnyĭ tsentr transplantologii i iskusstvennykh organov im. V.I. Shumakova" Minzdrava Rossii, Moskva

The current view of the pathogenesis of autoimmune pemphigus and the factors contributing to its development

Authors:

Davidenko E.B., Makhneva N.V., Beletskaia L.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2013;11(3): 4‑13

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Table of contents

THE CURRENT VIEW OF THE PATHOGENESIS OF AUTOIMMUNE PEMPHIGUS AND THE FACTORS CONTRIBUTING TO ITS DEVELOPMENT
THE CURRENT VIEW OF THE PATHOGENESIS OF AUTOIMMUNE PEMPHIGUS AND THE FACTORS CONTRIBUTING TO ITS DEVELOPMENT

To cite this article:

Davidenko EB, Makhneva NV, Beletskaia LV. The current view of the pathogenesis of autoimmune pemphigus and the factors contributing to its development. Russian Journal of Clinical Dermatology and Venereology. 2013;11(3):4‑13. (In Russ.)

 
 
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The review gives a large body of data of molecular biological studies to detect autoantibodies in autoimmune pemphigus and the etiological factors contributing to the development of this dermatosis. It considers the role of medications, foods, pesticides, ultraviolet radiation, virus infection, and cosmetics in the development of autoimmune pemphigus. Identifying and eliminating precipitating factors can promote a better prognosis and prevention of recurrences.

Keywords:

autoimmune pemphigus
pathogenesis
predisposing factors

Authors:

Davidenko E.B.

Moskovskiĭ nauchno-prakticheskiĭ tsentr dermatovenerologii i kosmetologii;
Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Makhneva N.V.

Moskovskiĭ nauchno-prakticheskiĭ tsentr dermatovenerologii i kosmetologii Departamenta zdravookhraneniia

Beletskaia L.V.

FGU "Federal'nyĭ nauchnyĭ tsentr transplantologii i iskusstvennykh organov im. V.I. Shumakova" Minzdrava Rossii, Moskva

List of references:

  1. Matushevskaya E.V. Pemfigus. Rus med zhurn 1997; 11: 701-713.
  2. Potekaev N.S. Dermatovenerologiya - sintez nauki i praktiki (izbrannye trudy). M: Meditsina 2004; 560.
  3. Khaitov R.M., Yarilin A.A., Pinegin B.V. Immunologiya: atlas. M: GEOTAR-Media 2011; 624.
  4. Makhneva N.V., Beletskaya L.V. Immunopatologicheskie aspekty autoimmunnykh bulleznykh dermatozov. Palmarium Acad Publ 2012; 411.
  5. Beletskaya L.V., Makhneva N.V. Mechenye antitela v normal'noi i patologicheskoi patologii (atlas). M: MNIPI 2000; 111.
  6. Stanley J.R. Pemphigus. In: Fitzpatrick's Dermatology in General Medicine. 6th ed. Ed. Mc Graw Hill. USA 2003; 558-574.
  7. Aoki V. Avaliação da técnica de imunoprecipitação com a desmogleína 1 recombinante em população de risco para o pênfigo foliáceo endêmico (fogo selvagem). Doctoral Thesis (Doutorado em Medicina) 1999; 80.
  8. Anhalt G.J., Labib R.S., Voorhees J.J, Beals T.F., Diaz L.A. Inductions of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Eng J Med 1982; 306: 1189-1192.
  9. Jeffes E.B., Kaplan R.P., Ahmed A.R. Acantholysis produced in vitro with pemphigus serum: hydrocortisone inhibits acantholysis, while dapsone and 6-mercaptopurine do not inhibit acantholysis. J Clin Immunol 1984; 4: 359-363.
  10. Bhol K., Mohimen A., Ahmed A.R. Correlation of subclasses of IgG with disease activity in pemphigus vulgaris. Dermatology 1994; 7189: Suppl 1: 785-789.
  11. Rock B., Martin C.R., Theofilopoulos A.N. The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus. N Engl J Med 1989; 320: 1463-1469.
  12. Warren S.J.P., Arteaga L., Rivitti E.A., Aoki V., Hans-Filho G., Qaqish B.F. The role of IgG subclass switch in the pathogenesis of fogo selvagem. J Invest Dermatol 2003; 120: 104-108.
  13. Hacker M.K., Janson M., Fairley J.A., Lin M.S. Isotypes and antigenic profiles of pemphigus foliaceus and pemphigus vulgaris autoantibodies. Clin Immunol 2002; 105: 1: 64-74.
  14. David M., Katzenelson V., Hazaz B. Determination of IgG subclasses in patients with pemphigus with active disease and in remission. Arch Dermatol 1989; 125: 787-790.
  15. Warren S.J.P., Lin M.S., Giudice G.J., Hoffmann R.G., Hans-Filho G., Aoki V. The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. N Engl J Med 2000; 343: 23-30.
  16. Cassian S., Sidoni M., Detlef Z. The relevance of igG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases. Arch Dermatol Res 2007; 299: 1-8.
  17. Jones C.C., Hamilton R.G., Jordon R.F. Subclasses distribution of human IgG autoantidodies in pemphigus. J Clin Immunol 1988; 8: 43-49.
  18. Kanwar A.J., Gurvinder P.T., Gursharan K.V. IgG subclasses in pemphigus vulgaris. Indian J Dermatol Venereol Leprol 1997; 63: 20-21.
  19. Wilson C.L., Wojnarowska F., Dean D., Pasricha J.S. IgG subclasses in pemphigus in Indian and UK populations. Clin Exp Dermatol 1993; 18: 226-230.
  20. Svirshchevskaya E.V., Lysenko A.A., Matushevskaya E.V., Kosinskii Yu.A. Autoimmunnaya puzyrchatka: identifikatsiya patogennykh epitopov desmogleina 3. Sovr probl dermatovenerol immunol i vrach kosmetol 2009; 3: 6: 5-13.
  21. Kricheli D., David M., Frusic-Zlotkin M., Goldsmith D., Rabinov M., Sulkes J., Milner Y. The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives. Br J Dermatol 2000; 143: 337-342.
  22. Michael D., Varda K., Bilhah H., Albert B.C., Miriam S. Determination of IgG subclasses in patients with pemphigus with active disease and in remission. Arch Dermatol 1989; 125: 787-790.
  23. Amagai M., Klaus-Kotvun V., Stanley J.R. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 1991; 67: 869-877.
  24. Ahmed A.R., Wagner R., Khatri K., Notani G., Awdeh Z., Alper C.A., Yunis E.J. Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA 1991; 88: 5056-5060.
  25. Brautbar C., Moscovitz M., Livshits T., Haim S., Hacham-Zadeh S., Cohen H.A., Sharon H.A., Nelken D. HLA-DRW4 in pemphigus vulgaris patients in Israel. Tissue Antigens 1985; 16: 238.
  26. Matzner Y., Erlich H.A., Brautbar C., Sanilevitch A., Landau M., Brenner S., Friedmann A. Identical HLA class II alleles predispose to drug-triggered and idiopathic pemphigus vulgaris. Acta Derm Venereol 1995; 75: 12-14.
  27. Ahmed A.R., Mohimen A., Yunis E.J., Mirza N.M., Kumar V., Beutner E.H. Linkage of pemphigus vulgaris to the major histocompatibility complex in healthy relatives of patients. J Exp Med 1993; 177: 419-424.
  28. Kavala M., Kocaturk O.E., Demirkesen C., Can B., Zindanci I., Turkoglu Z. Detection of pemphigus autoantibodies in healthy relatives of Turkish patients with pemphigus. Indian J Dermatol Venereol Leprol 2007; 73: 240-242.
  29. Scharf S.J., Long C.M., Erlich H.A. Sequence analysis of the HLA-DRΒ and HLA-DQΒ loci from three pemphigus vulgaris patients. Hum Immunol 1988; 22: 61-69.
  30. Beutner E.H., Jordan R.E., Chorzelski T.P. The immunopathology of pemphigus and bullous pemphigoid. J Invest Dermatol 1968; 51: 63.
  31. Brenner S., Ruocco V. Pemphigus registry: genetic and inducing factors to be explored. Int J Dermatol 1994; 33: 287-289.
  32. Bronson R., Brenner S., Frusic Zlotkin M., Michelle B., Tamir A., Milner Y. Circulating pemphigus IgG in families of patients with pemphigus. J Am Acad Dermatol 1997; 36: 44-52.
  33. Brenner S., Bialy Golan A., Anhalt G. Recognition of pemphigus antigens in drug-induced pemphigus vulgaris and pemphigus foliaceus. J Am Acad Dermatol 1997; 36: 919-923.
  34. Grunwald M., Katz I., Friedman-Birnbaum R. Association of pemphigus vulgaris and herpes simplex virus infection. Int J Dermatol 1986; 25: 392-393.
  35. Kerker B.J., Morison W.L. The photoaggravated dermatoses. Semin Dermatol 1990; 9: 70-77.
  36. Plumb R., Doolittle J. Paraneoplastic pemphigus in a patient with non-Hodgkin's lymphoma. Am J Hematol 1996; 52: 58-59.
  37. Ruach M., Ohel G., Rahav D. Pemphigus vulgaris and pregnancy. Obstet Gynecol Surv 1995; 50: 755-760.
  38. Stoughton R.V., Novack N. Disruption of tonofibriles and intercellular bridges by disulphide splitting agents. J Invest Dermatol 1956; 26: 127-136.
  39. Wohl Y., Brenner S. Pemphigus in Israel - an epidemiological analysis of cases in search of risk factors. Isr Med Ass J 2003; 5: 6: 410-412.
  40. Brenner S., Mashiah J., Tamir E. Pemphigus: an acronym for a disease with multiple etiologies. Skin Med 2003; 2: 163-167.
  41. Brenner S., Bialy-Golan A., Ruocco V. Drug-induced pemphigus. Clin Dermatol 1998; 3: 393-397.
  42. Brenner S., Wolf R., Ruocco V. Drug-induced pemphigus, I: a survey. Clin Dermatol 1993; 11: 41-44.
  43. Degos R., Touraine R., Belaich S. Pemphigus chez un malade traité par Pénicillamine pour maladie de Wilson. Bull Soc Fr Dermatol Syphil 1969; 76: 751-753.
  44. Enjolras D., Sedel D., Leibowitch M. Pemphigus induits. Ann Dermatol Venereol 1987; 114: 25-37.
  45. Woldegiogis S., Swerlick R.A. Pemphigus in the southeastern United States. South Med J 2001; 94: 694-698.
  46. Uzun S., Murat D., Akman A., Gunasti S., Uslular C., Memisoglu H.R. Pemphigus in the Mediterranean region of Turkey: a study of 148 cases. Int J Dermatol 2006; 45: 523-528.
  47. Fujita H., Iguchi M., Watanabe R., Asahina A. Pemphigus foliaceus induced by bucillamine. Eur J Dermatol 2007; 17: 1: 98-99.
  48. Maruani A., Machet M.C., Carlotti A., Giraudeau B., Vaillant L., Machet L. Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome. Am J Clin Pathol 2008; 130: 369-374.
  49. Tur E., Brenner S. Diet and Pemphigus. In Pursuit of Exogenous Factors in Pemphigus and Fogo Selvagem. Arch Dermatol 1998; 134: 1406-1410.
  50. Brenner S., Ruocco V., Wolf R., de Angelis E., Lombardi M.L. Pemphigus and dietary factors. Dermatology 1995; 190: 197-202.
  51. Negi K.S., Pant K.C. Less-known wild species of Allium L. (Amaryllidaceae) from mountainous regions of India. Econ Botany 1992; 46: 112-114.
  52. Chorzelski T.P., Hashimoto T., Jablonska S. Can pemphigus vulgaris be induced by nutritional factors? Eur J Dermatol 1996; 6: 284-286.
  53. Ruocco V., Brenner S., Lombardi M.L. A case of diet-related pemphigus. Dermatology 1996; 192: 373-374.
  54. Mitchell J.C., Jordan W.P. Allergic contact dermatitis from the radish, Raphanus sativus. Br J Dermatol 1974; 91: 183-189.
  55. Mobini N., Ahmed A.R. Immunogenetics of drug-induced bullous diseases. Clin Dermatol 1993; 11: 449-460.
  56. Lynfield Y.L., Pertschuk L.P., Zimmerman A. Pemphigus erythematosus provoked by allergic contact dermatitis. Arch Dermatol 1973; 108: 690-693.
  57. Tsankov N., Stransky L., Kostowa M. Induzierter Pemphigus durch beruflichen Kontakt mit Basochrom. Dermatos Derm Beruf Umwelt 1990; 38: 91-93.
  58. Sakagami H., Kuribayashi N., Iida M. Induction of DNA fragmentation by tannin- and lignin-related substances. Anticancer Res 1995; 15: 2121-2128.
  59. Hunt A.F., Reed M.I. Tannic acid and chromic chloride-induced binding of protein to red cells: a preliminary study of possible binding sites and reaction mechanisms. Med Lab Sci 1990; 47: 189-194.
  60. Muzykantov V.R., Smirnov M.D., Zaltzman A.B., Samokhin G.P. Tannin-mediated attachment of avidin provides complement-resistant immunoerythrocytes that can be lysed in the presence of activator of complement. Anal Biochem 1993; 208: 338-342.
  61. Vincentini-Diaz V.E., Takahashi C.S. Action of an extract of Stryphnodendron obovatum Benth seed on rat bone marrow and on human lymphocytes. Rev Bras Genet 1993; 16: 175-185.
  62. Okezie B.O., Kosikowski F.V. Cassava as a food. Crit Rev Food Sci Nutr 1982; 17: 259-275.
  63. Butov Yu.S., Vasenova V.Yu., Izmerova N.I., Selisskii G.D. Zabolevaniya kozhi, svyazannye s vozdeistviem pestitsidov. Ros zhurn kozhn i ven bol 2011; 6: 3-6.
  64. Krain L.S. Pemphigus. Epidemiological and survival characteristics of 59 patients, 1955-1973. Arh Dermatol 1974; 110: 862-865.
  65. Lambert J., Schepea S., Jansseas J. Skin lesions as a sign of subacutepentachlorophenol intoxication. Acta Dermatol Venerol 1986; 66: 170-172.
  66. Robinson N.D., Hashimoto T., Amagai M., Chan L.S. The new pemphigus variants. J Am Acad Dermatol 1999; 40: 649-667.
  67. Grando S.A. Autoimmunity to keratinocyte acetylcholine receptors in pemphigus. Dermatology 2000; 201: 290-295.
  68. Kramer M.D., Schaefer B., Reinartz J. Plasminogen activation by human keratinocytes: molecular pathways and cell-biological consequences. Biol Chem Hopper-Seyler 1995; 376: 131-141.
  69. Blasi F. UPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways? Immunol Today 1997; 18: 415-417.
  70. Shmitt M., Wilhelm O., Janicke F. Urokinase-type plasminogen activator (uPA) and its receptor (CD87): a new target in tumar invasion and metastasis. J Obstet Gynecol 1995; 21: 151-165.
  71. Schaefer B.M., Jaeger C.J., Kramer M.D. Plasminogen activator system in pemphigus vulgaris. Br J Dermatol 1996; 135: 726-732.
  72. Wilkinson J.E., Smith C.A., Suter M.M., Falchek W., Lewis R.M. Role of plasminogen activator in pemphigus vulgaris. Am J Pathol 1989; 134: 561-569.
  73. Hashimoto K., Wun T.C., Baird J., Lazarus G.S., Jensen P.J. Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG-induced acantholysis by a purified plasminogen activator inhibitor. J Invest Dermatol 1989; 92: 310-314.
  74. Morioka S., Lazarus G.S., Jensen P.J. Involvement of urokinase-type plasminogen activator in acantholysis induced by pemphigus IgG. J Invest Dermatol 1987; 89: 474-477.
  75. Naito K., Morioka S., Nakajima S., Ogawa H. Proteinase inhibitors block formation of pemphigus acantholysis in experimental models of neonatal mice and skin explants: effects of synthetic and plasma proteinase inhibitors on pemphigus acantholysis. J Invest Dermatol 1989; 93: 173-177.
  76. Xue W., Hashimoto K., Toi Y. Functional involvement of urokinase-type plasminogen activator receptor in pemphigus acantholysis. J Cutan Pathol 1998; 25: 469-474.
  77. Hashimoto K., Shafran K.M., Webber P.S., Lazarus G.S., Singer K.H. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. J Exp Med 1983; 157: 259-272.
  78. Marschall C., Lengyel E., Nobutoh T., Braungart E., Dauwes K., Simon A., Magdolen V., Reuning U., Degitz K. UVB increase Urokinase-type plasminogen activator receptor (uPAR) expression. J Invest Dermatol 1999; 113: 69-76.
  79. Ahmed A.R., Rosen G.B. Viruses in pemphigus. Int J Dermat 1989; 28: 209-217.
  80. Jordon R.E. Immunopathology. In: Pemphigus: current concepts moderator. Ed. A.R. Ahmed. Ann Intern Med 1980; 92: 396-405.
  81. Markitziu A., Pisanty S. Pemphigus vulgaris after infections by Epstein-Barr virus. Int J Dermatol 1993; 32: 917-918.
  82. Ruocco V., Rossi A., Satriano R.A., Sacerdoti G., Astarita Pisani M. Pemphigas foliaceus in a haemophilic child: cytomegalovirus induction? Acta Dermatol Venereol (Stockh) 1982; 62: 534-537.
  83. Ruocco V., Wolf R., Ruocco E., Baroni A. Viruses in pemphigus: a casual or casual relationship? Int J Dermat 1996; 35: 782-784.
  84. Schlupen E.M., Wollenberg A., Hanel S., Stumpenhausen G., Volkenandt M. Detection of herpes simplex virus in exacerbated pemphigus vulgaris by polymerase chain reaction. Dermatology 1996; 192: 312-316.
  85. Tufano M.A., Baroni A., Buammino E., Ruocco E., Lombardi M.L., Ruocco V. Detection of herpesvirus DNA in peripheral blood mononuclear cells and skin lesions of patients with pemphigus by polymerase chain reaction. Br J Dermatol 1999; 141: 1033-1039.
  86. Indgin S.N., Katz S.I., Connor J.D. Pemphigus and herpes simplex - antibody response to corticosteroids in a patients. Arch Dermatol 1970; 102: 333-336.
  87. Nabai H., Rahbari H. Multinucleated epithelial cells in pemphigus vulgaris; possible association of viral infection. J Am Acad Dermatol 1980; 2: 175-176.
  88. Silverstein E.H., Bumett J.W. Kaposi's varicelliform eruption complicating pemphigus foliaceus. Arch Dermatol 1967; 95: 214-216.
  89. Memar O.M., Rady P.L., Goldblum R.M., Tyring S.K. Human herpesvirus 8 DNA sequences in a patients with pemphigus vulgaris but without HIV infection or Kaposi's sarcoma. J Invest Dermatol 1997; 108: 1: 118-119.
  90. Memar O.M., Rady P.L., Goldblum R.M., Yen A., Tyring S.K. Human herpesvirus 8 DNA sequences in blistering skin from patients with pemphigus. Arch Dermatol 1997; 133: 1247-1251.
  91. Jang H.S., Oh C.K., Lim J.Y., Jun E.S., Kim Y.S., Kwon K.S. Detection of human herpesvirus 8 DNA in pemphigus and chronic blistering skin diseases. J Korean Med Sci 2000; 15: 4: 442-448.
  92. Trattner A., Hodak E., David M., Sandbank M. The appearance of Kaposi's sarcoma during corticosteroid therapy. Cancer 1993; 72: 1779-1783.
  93. Haouet H., Ben Hamida A., Haouet S., Chaffai M., Ben Osman A. Tunisian pemphigus. Apropos of 70 cases. (Experience of the dermatology department of La Rabta Hospital 1974-1992). Ann Dermatol Venereol 1996; 123: 1: 9-11.
  94. Morini J.P., Jomaa B., Gorgi Y. Pemphigus foliaceus in young women. An endemic focus in the Sousse area of Tunisia. Arch Dermatol 1993; 129: 69-73.
  95. Bastuji-Garin S., Souissi R., Blum L. Comparative epidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tunisian women. J Invest Dermatol 1995; 104: 302-305.
  96. Bastuji-Garin S., Turki H., Mokhtar I., Nouira R., Fazaa B., Jomaa B., Zahaf A., Osman A.B., Souissi R., Hémon D., Roujeau J.C., Kamoun M.R. Possible relation of Tunisian pemphigus with traditional cosmetics: a multicenter case-control study. Am J Epidemiol 2002; 155: 3: 249-256.
  97. Al-Hazzaa S.A., Krahn P.M. Kohl: a hazardous eyeliner. Int Ophthalmol 1995; 19: 83-88.
  98. Parry C., Eaton J. Kohl: a lead-hazardous eye makeup from the Third World to the First World. Environ Health Perspect 1991; 94: 121-123.
  99. Etienne A., Piletta P., Hauser C., Pasche-Koo F. Ectopic contact dermatitis from henna. Contact Dermatitis 1997; 37: 4: 183.
  100. Lestringant G.G., Bener A., Frossard P.M. Cutaneous reactions to henna and associated additives. Br J Med 1999; 141: 598-600.

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