This literature review is devoted to dermato-respiratory syndrome with special reference to the data on relationship between various allergic diseases that have become available in the recent years. It is shown that atopy begins as atopic dermatitis that is followed by the development of allergic rhinitis and bronchial asthma. In this country, these conditions taken together are referred to as dermato-respiratory syndrome. The prevalence of atopic diseases in various countries has increased in the last decade which accounts for the continuous interest of researchers in their investigation and necessitates the search for new approaches to the treatment of allergic disorders. Previous studies of pathogenesis of atopic dermatitis and bronchial asthma were focused on the mechanisms of adaptive immunity with the emphasis on the Th1/Th2-concept. The importance of systemic disbalance of Th2-lymphocytes in conjunction with the elevated levels of IgE and eosinophils in the development of atopic conditions is currently universally accepted. The role of dendritic cells is actively investigated. Mutations of the filaggrin gene have been shown to play the leading part in pathogenesis of atopic dermatitis and progression of atopic march. Epidemiological, clinical, and fundamental research have demonstrated the necessity of taking into account anatomical, physiological, and immunopathological factors for the choice of therapeutic strategies. The advent of humanized monoclonal anti-IgE-antibodies that are currently applied extensively for the treatment of bronchial asthma opened up the new prospects for the management of patients presenting with atopic dermatitis.