The authors present successful hybrid surgical intervention of a patient with multifocal atherosclerosis, aneurysmal lesions of infrarenal aorta, iliac and femoral arteries. Taking into account multi-level damage to aortofemoral segment and possible technical difficulties of staged treatment, the authors preferred a hybrid surgical intervention: stenting of abdominal aorta and iliac arteries, resection femoral artery aneurysms with external iliac-deep femoral bypass. Success of this intervention lies in exclusion of aortic and iliac artery aneurysms, excision of aneurysms of femoral arteries with reconstruction, relief of critical ischemia within the same surgical session. Considering sporadic nature of such cases, we considered it appropriate to share our experience, as well as provide literature data on modern treatment approaches for these patients.