Serum ghrelin changes after bariatric surgery

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OBJECTIVE

To study the effect of bariatric surgery on serum ghrelin in patients with morbid obesity.

MATERIAL AND METHODS

We experimentally analyzed serum ghrelin in 96 rats. Of these, 84 rats underwent sleeve gastrectomy, and 12 rats comprised the control group (no surgery). We measured body weight and serum ghrelin using ELISA method after 1, 3, 7, 14, 21 and 30 days after surgery. Serum ghrelin was studied before and after bariatric surgery in 23 patients with morbid obesity.

RESULTS

Baseline serum ghrelin was lower in larger rats and obese patients compared to normal body weight. We found no decrease in serum ghrelin after resection of fundal ghrelin-releasing part of the stomach.

CONCLUSION

Stomach volume changes after restrictive bariatric surgery (sleeve resection or gastroplication) are accompanied by mild increase in serum ghrelin. This increment is greater after more significant body weight loss after surgery. Similar researches will help to find new treatment strategies for pathological obesity.

Keywords:

experiment

bariatric surgery

ghrelin

Authors:

Galimov O.V.

Bashkir State Medical University

ORCID: 0000-0003-4832-1682

Khanov V.O.

Bashkir State Medical University

ORCID: 0000-0002-1880-0968

Nasyrova K.V.

Bashkir State Medical University

ORCID: 0000-0003-3997-5385

Galimov D.O.

Bashkir State Medical University

ORCID: 0000-0003-1314-5017

Received:

01.09.2023

Accepted:

27.10.2023

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