Aim — to improve immediate results of treatment in patients with breast cancer using a new method of reconstruction. Material and methods. Prospective study included 215 patients with breast cancer. Patients were treated at the Samara Regional Clinical Oncology Center in 2013—2016. Patients of the control group (n=111) underwent subcutaneous mastectomy followed by conventional endoprosthesis deployment with its complete muscular covering. Patients of the main group (n=104) underwent subcutaneous mastectomy with a new method of single-stage reconstruction. Results. Mean time of operation was 115±15 min in the control group and 90±10 min in the main group (p=0.000). Intraoperative blood loss reached 115±15 ml in the control group, 70±10 ml — in the main group (p=0.000). Duration of postoperative lymphorrhea was 14.6±3.5 days in the control group, 10±3.4 days — in the main group (p=0.000). Postoperative hospital-stay was 17.1±3.7 day in the control group and 14.2±2.4 days in the main group (p=0.001). Conclusion. New surgical approach significantly improves early outcomes in patients with breast cancer in comparison with those who undergo conventional surgical repair.