Aim. To determine significant predictors of long-term outcomes of surgery for portal cholangiocarcinoma. Material and methods. Analysis included 49 out of 84 patients who were operated at the Vishnevsky Institute of Surgery in 2003—2016. Morphological examination (2011—2016) revealed great percentage of following positive variables: micro- (42.9%) and lymphovascular invasion (11.8%), positive resection margin (59.2%), perineural invasion (83.3%), depth of invasion — (83.3%), cells in surrounding fatty tissue (92.3%), invasion of entire thickness of bile ducts’ walls (57.1%). Hemihepatectomy was carried out in 50 (59.5%) cases, advanced hemihepatectomy — in 16 (19%) patients. Left-sided hemihepatectomy (34.6%) was more common compared with right-sided hemihepatectomy (8.6%) for biliary confluence lesion (Bismuth—Corlette type IV). Results. TNM stage (p=0.29), tumor localization Bismuth—Corlette type (p=0.10), regional lymph nodes metastases (p=0.77) do not significantly affect survival in univariate analysis. At the same time, TNM stage was significant factor if patients dividing into groups was considered (p=0.05). In regression analysis tumor cells differentiation (p=0.00028), positive resection margin (p=0.0034), perineural invasion and depth of invasion (p=0,00086) were significant predictors of survival. Multivariate analysis confirmed prognostic role of lymphovascular invasion alone (p=0.05). There was no correlation between survival and TNM stage (η=0.057), depth of invasion (η= –0.229) and lymphovascular invasion (η= –0.143645). There was significant reverse moderate correlation between survival and perineural invasion (η= – 0.468750), resection margin (η= –0.558) and tumor differentiation grade (η= –0.481). Conclusion. Significant predictors of long-term outcomes of surgery for portal cholangiocarcinoma are TNM stage, lymphovascular invasion, tumor cells differentiation, perineural invasion.