Gastropancreatoduodenal resection for malignant tumors, complicated with obstructive jaundice

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The experience of 329 gastropancreatoduodenal resections for malignant tumors of the periampullary zone has been reviewed. The obstructive jaundice complicated the disease in 237 (70%) patients. The fact required various modalities of the preoperative artificial bile drainage. To evaluate the jaundice influence on the perioperative period, patients were divided in 4 groups, considering the bile drainage modality and bilirubin blood levels. The early postoperative period was respectively analyzed, which led to the conclusion that bilirubin blood level has no influence on either intraoperative characteristics or postoperative morbidity and mortality. For the reason of that, radical treatment of the periampullary cancer, complicated by the obstructive jaundice, does not require preoperative bile drainage.

Keywords:

obstructive jaundice

preoperative bile drainage

gastropancreatoduodenal resection

Authors:

Patiutko Iu.I.

Blokhin National Medical Research Center of Oncology

RSCI AuthorID: 137980
Scopus AuthorID: 55666204300
ORCID: 0000-0001-9254-1346

Kudashkin N.E.

Rossiĭskiĭ onkologicheskiĭ nauchnyĭ tsentr im. N.N. Blokhina RAMN, Moskva

SPIN RSCI: 3574-8344
Scopus AuthorID: 54885375500
ORCID: 0000-0003-0504-585X

Kotel'nikov A.G.

Abgarian M.G.

Khirurgicheskoe otdelenie opukholeĭ pecheni i podzheludochnoĭ zhelezy Rossiĭskogo onkologicheskogo nauchnogo tsentra im. N.N. Blokhina RAMN, Moskva

List of references:

Kasatkin V.F. Puti uluchsheniya neposredstvennykh rezul'tatov pankreatoduodenal'noi rezektsii pri periampulyarnom rake. Khirurgiya 2008; 10: 10-16.
Kubyshkin V.A. Rak podzheludochnoi zhelezy. Consilium Medicum. Khirurgiya 2003; 5: 8.
Kukushkin A.V. Profilaktika i lechenie oslozhnenii antegradnykh rentgenoendobiliarnykh vmeshatel'stv u bol'nykh s mekhanicheskoi zheltukhoi opukholevoi etiologii: Dis. … kand. med. nauk. M 2005.
Patyutko Yu.I., Kotel'nikov A.G. Khirurgiya raka organov biliopankreatoduodenal'noi zony. M: Meditsina 2007.
Shabunin A.V., Bedin V.V., Tavobilov M.M. i dr. Protokol diagnostiki bol'nykh s mekhanicheskoi zheltukhoi. Mosk. assambleya, 6-ya. Zdorov'e stolitsy: Sb. tez. M 2007; 150.
Armstrong C.P., Dixon J.M., Taylor T.V., Davies G.C. Surgical experience of deeply jaundiced patients with bile duct obstruction. Br J Surg 1984; 71: 3: 234-238.
Assimakopoulos S.F., Scopa C.D., Zervoudakis G. et al. Bombesin and neurotensin reduce endotoxemia, intestinal oxidative stress, and apoptosis in experimental obstructive jaundice. Ann Surg 2005; 241: 159-167.
Cahill C.J. Prevention of postoperative renal failure in patients with obstructive jaundice - the role of bile salts. Br J Surg 1983; 70: 590-595.
Clements W.D., McCaigue M., Erwin P. et al. Biliary decompression promotes Kupffer cell recovery in obstructive jaundice. Gut 1996; 38: 925-931.
Duffas J.P., Suc B., Msika S. et al. A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy. Am J Surg 2005; 189: 6: 720-729.
Fathy O., Abdel-Wahab M., Elghwalby N. et al. Surgical management of peri-ampullary tumors: a retrospective study. Hepatogastroenterology 2008; 55: 85: 1463-1469.
Glenn F., Evans J.A., Mujahed Z., Thorbjarnsarson B. Percutaneous transhepatic cholangiography. Ann Surg 1962; 156: 451-462.
Gouma D.J., van Geenen R.C., van Gulik T.M. et al. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Ann Surg 2000; 232: 6: 786-795.
Greig J.D., Krukowski Z.H., Matheson N.A. Surgical morbidity and mortality in one hundred and twenty-nine patients with obstructive jaundice. Br J Surg 1988; 75: 3: 216-219.
Heslin M.J., Brooks A.D., Hochwald S.N. et al. A preoperative biliary stent is associated with increased complications after pancreatoduodenectomy. Arch Surg 1998; 133: 149-154.
Hirazawa K., Hazama S., Oka M. Depressed cytotoxic activity of hepatic nonparenchymal cells in rats with obstructive jaundice. Surgery 1999; 126: 900-907.
Hu J.X., Miao X.Y., Zhong D.W. et al. Surgical treatment of primary duodenal adenocarcinoma. Hepatogastroenterology 2006; 53: 72: 858-862.
Hunt D.R., Allison M.E., Prentice C.R. et al. Endotoxemia, disturbance of coagulation, and obstructive jaundice. Am J Surg 1982; 144: 325-329.
Karsten T.M., Davids P.H., van Gulik T.M. et al. Effects of biliary endoprostheses on the extrahepatic bile ducts in relation to subsequent operation of the biliary tract. J Am Coll Surg 1994; 178: 343-352.
Karsten T.M., Coene P.P., van Gulik T.M. et al. Morphologic changes of extrahepatic bile ducts during obstruction and subsequent decompression by endoprosthesis. Surgery 1992; 111: 562-568.
Koyama K., Takagi Y., Ito K. et al. Experimental and clinical studies on the effect of biliary drainage in obstructive jaundice. Am J Surg1981; 142: 293-299.
Ljungdahl M., Osterberg J., Ransjo U. et al. Inflammatory response in patients with malignant obstructive jaundice. Scand J Gastroenterol 2007; 42: 94-102.
Maki T., Sato T., Kakizaki G. et al. Pancreatoduodenectomy for periampullary carcinomas. Appraisal of two-stage procedure. Arch Surg 1966; 92: 825-833.
McPhee J.T., Hill J.S., Whalen G.F. et al. Perioperative mortality for pancreatectomy: a national perspective. Ann Surg 2007; 246: 246-253.
McPherson G.A., Benjamin I.S., Boobis A.R. et al. Antipyrine elimination as a dynamic test of hepatic functional integrity in obstructive jaundice. Gut 1982; 23: 734-738.
Nakayama T., Ikeda A., Okuda K. Percutaneous transhepatic drainage of the biliary tract: technique and results in 104 cases. Gastroenterology 1978; 74: 554-559.
Papadopoulos V., Filippou D., Manolis E. et al. Haemostasis impairment in patients with obstructive jaundice. J Gastrointestin Liver Dis 2007; 16: 2: 177-186.
Parks R.W., Clements W.D., Smye M.G. et al. Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage. Br J Surg 1996; 83: 1345-1349.
Pitt H.A., Gomes A.S., Lois J.F. et al. Does preoperative percutaneous biliary drainage reduce operative risk or increase hospital cost? Ann Surg 1985; 201: 545-553.
Povoski S.P., Karpeh M.S.J., Conlon K.C. et al. Association of preoperative biliary drainage with postoperative outcome following pancreaticoduodenectomy. Ann Surg 1999; 230: 131-142.
Sakrak O., Akpinar M., Bedirli A. et al. Short and long-term effects of bacterial translocation due to obstructive jaundice on liver damage. Hepatogastroenterology 2003; 50: 1542-1546.
Satoi S., Takai S., Matsui Y. et al. Less morbidity after pancreaticoduodenectomy of patients with pancreatic cancer. Pancreas 2006; 33: 45-52.
Sohn T.A., Yeo C.J., Cameron J.L. et al. Do preoperative biliary stents increase postpancreaticoduodenectomy complications? J. Gastrointest Surg 2000; 4: 258-267.
Sewnath M.E., Karsten T.M., Prins M.H. et al. A meta-analysis on the efficacy of preoperative biliary drainage for tumors causing obstructive jaundice. Ann Surg 2002; 236: 17-27.
Takada T., Hanyu F., Kobayashi S. et al. Percutaneous transhepatic cholangial drainage: direct approach under fluoroscopic control. J Surg Oncol 1976; 8: 83-97.
Uchida H., Shibata K., Iwaki K. et al. Ampullary cancer and preoperative jaundice: possible indication of the minimal surgery. Hepatogastroenterology 2009; 56: 93: 1194-1198.
Van der Gaag N.A., Gouma D.J. A study of the value of preoperative biliary-tract drainage in the treatment of periampullary tumours: the DROP-trial. Ned Tijdschr Geneeskd 2006; 4: 150: 9: 509-511.
Vargas R., Nino-Murcia M., Trueblood W., Jeffrey R.B.Jr. MDCT in Pancreatic adenocarcinoma: prediction of vascular invasion and resectability using a multiphasic technique with curved planar reformations. AJR Am J Roentgenol 2004; 182: 2: 419-425.
Waqar S.H., Malik Z.I., Razzaq A. et al. Frequency and risk factors for wound dehiscence/burst abdomen in midline laparotomies. J Ayub Med Coll Abbottabad 2005; 17: 70-73.
Whipple A.O., Parsons W.B., Mullins C.R. Treatment of carcinoma of the ampulla of Vater. Ann Surg1935; 102: 763-779.

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