Effectiveness of different cardioplegia options for aortic valve replacement

Magomedova G.F.

Petrovsky Russian Scientific Center of Surgery

ORCID: 0000-0003-1897-2919

Huseynova S.R.

Sechenov First Moscow State Medical University

ORCID: 0009-0009-2386-7049

Akhmedova D.K.

Dagestan State Medical University

Shikhverdieva E.N.

Dagestan State Medical University

ORCID: 0009-0007-2709-1941

Babaev S.M.

Dagestan State Medical University

ORCID: 0009-0007-8216-1885

Mirzabekova S.Z.

Dagestan State Medical University

ORCID: 0009-0005-5370-5391

Effectiveness of different cardioplegia options for aortic valve replacement

Authors:

Magomedova G.F., Huseynova S.R., Akhmedova D.K., Shikhverdieva E.N., Babaev S.M., Mirzabekova S.Z.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(3): 301‑305

DOI: 10.17116/kardio202417031301

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To cite this article:

Magomedova GF, Huseynova SR, Akhmedova DK, Shikhverdieva EN, Babaev SM, Mirzabekova SZ. Effectiveness of different cardioplegia options for aortic valve replacement. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(3):301‑305. (In Russ.)
https://doi.org/10.17116/kardio202417031301

Подписка 2025 (Russian Journal of Cardiology and Cardiovascular Surgery)

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OBJECTIVE

To analyze and compare the results of various types of cardioplegia in aortic valve replacement.

MATERIAL AND METHODS

PubMed, Embase, Cohrane CENTRAL, E-library and Medline databases were reviewed. We used the following keywords: «aortic valve replacement», «cardioplegia», «cold blood cardioplegia», «warm blood cardioplegia», «crystalloid cardioplegia», «blood cardioplegia». Finally, we found 53 articles published between 1998 and 2021.

RESULTS

When comparing cold blood cardioplegia and crystalloid cardioplegia in patients with reduced left ventricular ejection fraction <30%, we found higher survival and lower serum markers of myocardial damage after cold blood cardioplegia. Compared to warm blood cardioplegia, crystalloid cardioplegia reduced the incidence of inotropic support (p<0.05) within 24 hours after surgery. Spontaneous rhythm recovery was more common in the same group (p<0.05). When comparing warm and cold blood cardioplegia, we found shorter postoperative ICU-stay after warm cardioplegia. Spontaneous rhythm recovery was more common after warm blood cardioplegia (p<0.05), and lower incidence of postoperative atrial fibrillation was observed (p<0.05). We found higher left ventricular ejection fraction after warm blood cardioplegia (p<0.05). When comparing cold blood cardioplegia and Del Nido cardioplegia, we found higher incidence of inotropic support after blood cardioplegia (p<0.05). Incidence of kidney damage was higher after blood cardioplegia (p<0.05).

CONCLUSION

Warm blood may be preferable in aortic valve replacement if it is applied in accordance with recommendations and characteristics of each patient.

Keywords:

aortic valve replacement

cardioplegia

warm blood cardioplegia

cold blood cardioplegia

crystalloid cardioplegia

Authors:

Magomedova G.F.

Petrovsky Russian Scientific Center of Surgery

ORCID: 0000-0003-1897-2919

Huseynova S.R.

Sechenov First Moscow State Medical University

ORCID: 0009-0009-2386-7049

Akhmedova D.K.

Dagestan State Medical University

Shikhverdieva E.N.

Dagestan State Medical University

ORCID: 0009-0007-2709-1941

Babaev S.M.

Dagestan State Medical University

ORCID: 0009-0007-8216-1885

Mirzabekova S.Z.

Dagestan State Medical University

ORCID: 0009-0005-5370-5391

Received:

10.02.2024

Accepted:

29.02.2024

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