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Barbarash O.L.

Research Institute for Complex Issues of Cardiovascular Diseases

Khryachkova O.N.

Research Institute for Complex Issues of Cardiovascular Diseases

Novitskaya A.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Zykov M.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Sedykh D.Yu.

Research Institute for Complex Issues of Cardiovascular Diseases

Kashtalap V.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Shibanova I.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Prognostic role of biological markers of bone metabolism in patients with coronary artery disease after coronary artery bypass grafting

Authors:

Barbarash O.L., Khryachkova O.N., Novitskaya A.A., Zykov M.V., Sedykh D.Yu., Kashtalap V.V., Shibanova I.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(6): 481‑488

DOI: 10.17116/kardio202013061481

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Table of contents

PROGNOSTIC ROLE OF BIOLOGICAL MARKERS OF BONE METABOLISM IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER CORONARY ARTERY BYPASS GRAFTING
PROGNOSTIC ROLE OF BIOLOGICAL MARKERS OF BONE METABOLISM IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER CORONARY ARTERY BYPASS GRAFTING

To cite this article:

Barbarash OL, Khryachkova ON, Novitskaya AA, Zykov MV, Sedykh DYu, Kashtalap VV, Shibanova IA. Prognostic role of biological markers of bone metabolism in patients with coronary artery disease after coronary artery bypass grafting. Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(6):481‑488. (In Russ.)
https://doi.org/10.17116/kardio202013061481

 
ЭндоКард
Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the role of traditional risk factors and biological markers of osteo-coronary comorbidity for the prognosis in patients with coronary artery disease after coronary artery bypass surgery.

MATERIAL AND METHODS

The study included 111 men under the age of 75 years with coronary artery disease and angina pectoris CCS class I—III who underwent coronary artery bypass surgery. We have assessed the incidence of endpoints (death, myocardial infarction, recurrence/aggravation of angina attacks), risk factors and predictors of poor prognosis in patients with and without cardiovascular events within 3 years after surgery.

RESULTS

After 3 years, 21 (22.1%) patients developed adverse outcomes. Patients with cardiovascular events were characterized by high smoking rate (p=0.050), high biomarkers of bone resorption (alkaline phosphatase (p=0.030), osteocalcin (p=0.010) osteopontin (p=0.040)), low levels of osteoprotegerin (p=0.020). Postoperative period was characterized by negative dynamics of proatherogenic lipid factors. The predictors of adverse outcomes within 3 years after coronary artery bypass surgery were high osteopontin level (>8.3 ng/ml, p=0.023), smoking (p=0.050), high parathyroid hormone (>49.1 pg/ml, p=0.014), osteocalcin (>26.8 ng/ml, p=0.020), alkaline phosphatase (>186 u/l, p=0.041). Moreover, high preoperative levels of osteocalcin (p=0.037) and parathyroid hormone (p=0.012) were significant factors with risk augmentation by 23.6% for one elevated factor and 75% for increase of both factors.

CONCLUSION

A three-year unfavorable prognosis of coronary artery bypass surgery is associated with increased preoperative osteocalcin, parathyroid hormone, osteopontin, alkaline phosphatase, smoking and negative lipid dynamics.

Keywords:

coronary artery bypass surgery
prognosis
biological markers
osteo-coronary comorbidity

Authors:

Barbarash O.L.

Research Institute for Complex Issues of Cardiovascular Diseases

Khryachkova O.N.

Research Institute for Complex Issues of Cardiovascular Diseases

Novitskaya A.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Zykov M.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Sedykh D.Yu.

Research Institute for Complex Issues of Cardiovascular Diseases

Kashtalap V.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Shibanova I.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Received:

18.05.2020

Accepted:

03.06.2020

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References:

  1. Galyavich AS, Khairullin RN, Baleeva LV, et al. Risk factors of coronary artery disease in 27425 outpatients. Russian Journal of Cardiology. 2019;(6):23-26. (In Russ.). https://doi.org/10.15829/1560-4071-2019-6-23-26
  2. Akhmedov VA, Shevchenko AS, Isaeva AS. Current view on the atherosclerosis emergence and progression factors. RMJ. Medical Review. 2019;1(II):57-62. (In Russ.).
  3. Hoefer IE, Steffens S, Ala-Korpela M, et al. Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J. 2015;36(39):2635-2642. https://doi.org/10.1093/eurheartj/ehv236
  4. Polonskaya YaV, Kashtanova EV, Murashev IS i dr. The relationship of the main indicators of calcium and lipid metabolism with atherosclerosis of the coronary arteries. Atherosclerosis and dyslipidemia. 2015;1:24-29.(In Russ.).
  5. Barbarash OL, Lebedeva NB, Kokov AN et al. Relationship of biochemical markers of bone metabolism, osteopenic syndrome and coronary atherosclerosis in men with stable coronary heart disease. Atherosclerosis. 2015;11(2):5-13. (In Russ.).
  6. Chen Z, Qureshi AR, Brismar TB, et al. Differences in association of lower bone mineral density with higher coronary calcification in female and male end-stage renal disease patients. BMC Nephrol. 2019;20(59). https://doi.org/10.1186/s12882.019.1235-z
  7. Lutai MI. Calcification of coronary arteries, aorta, heart palms and coronary heart disease: pathophysiology, interrelation, prognosis, risk stratification. Part 2. Calcinosis of coronary arteries: Diagnosis, interpretation of data is interrelated with other diagnostic methods for detecting coronary heart disease. Ukrainian Cardiology Journal. 2014;(6):92-100. (In Russ.).
  8. Barbarash OL, Semjonov VYu, Samorodskaya IV, et al. Comorbidity in coronary heart disease patients undergoing bypass grafting: an experience of two surgery centers. Russian Journal of Cardiology. 2017;22(3):613. (In Russ.). https://doi.org/10.15829/156.040.7120173613
  9. McNeely C, Markwell S, Vassileva C. Trends in patient characteristics and outcomes of coronary artery bypass grafting in the 2000 to 2012 Medicare Population. Ann Thorac Surg. 2016;102(1):1328. https://doi.org/10.1016/j.athoracsur.2016.01.016
  10. Barbarash O, Lebedeva N, Kokov A, et al. Decreased cathepsin K plasma level may reflect an association of osteopenia/osteoporosis with coronary atherosclerisis and coronary artery calcification in male patients with stable angina. Heart, Lung and Circulation. 2016;25(7):691-697.  https://doi.org/10.1016/j.hlc.2016.02.002
  11. Panov AV, Abesadze IT, Alugishvili MZ. et al. Register of patients who underwent coronary artery bypass grafting with stable coronary heart disease (Ricochet program). Arterial hypertension. 2014;20(6):568-577. (In Russ.).
  12. Barinova IV, Seredenina EM, Orlova YaA, Ageev FT. Mechanisms of interactions between osteoporosis and cardiovascular diseases. Cardiology Bulletin. 2012;7(1):51-56. (In Russ.).
  13. Hamerman D. Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies. QJM. 2005;98(7):467-484.  https://doi.org/10.1093/qjmed/hci077
  14. Bolotnova TV, Platitsyna NG, Kuslivaya ON. Osteoporosis in patients with coronary heart disease and arterial hypertension. Doctor. 2014; 2:2-4.(In Russ.).
  15. Adler RA. Osteoporosis in men: a review. Bone Res. 2014;2:14001. https://doi.org/10.1038/boneres.2014.1
  16. Skripnikova IA. Relationship of atherosclerosis-induced cardiovascular diseases and osteoporosis in postmenopausal women. Current Rheumatology. 2008;2(1):41-47. (In Russ.). https://doi.org/10.18087/cardio.2019.4.10247
  17. Zykov MV, Khryachkova ON, Kashtalap VV i dr. Coronary calcification dynamics and its relationship with the clinical course of coronary heart disease and osteopenic syndrome. Cardiology. 2019;59(4):12-20. (In Russ.). https://doi.org/10.18087/cardio.2019.4.10247
  18. Garimella PS, Ix JH, Katz R, et al. Association of albumin-creatinine ratio and cystatin C with change in ankle-brachial index: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis. 2015;65(1):33-40.  https://doi.org/10.1053/j.ajkd.2014.05.014
  19. Folsom AR, Alonso A, Misialek JR, et al. Parathyroid hormone concentration and risk of cardiovascular diseases: the Atherosclerosis Risk in Communities (ARIC) study. American Heart Journal. 2014;168(3):296-302.  https://doi.org/10.1016/j.ahj.2014.04.017
  20. Chen SJ, Lin CS, Lin CL, Kao CH. Osteoporosis is associated with high risk for coronary heart disease: a population-based cohort study. Medicine (Baltimore). 2015;94(27):e11.  https://doi.org/10.1097/MD.000.000.0000001146
  21. Lello S, Capozzi A, Scambia G. Osteoporosis and cardiovascular disease: an update. Gynecol Endocrinol. 2015;31(8):590-594.  https://doi.org/10.3109/09513.590.2015.1041908
  22. Park KY, Chung PW, Kim YB, et al. Serum vitamin D status as a predictor of prognosis in patients with acute ischemic stroke. Cerebrovascular Diseases. 2015;40(1-2):73-80.  https://doi.org/10.1159/000434691
  23. Scatena M, Liaw L, Giachelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol. 2007;27:2302-2309. https://doi.org/10.1161/ATVBAHA.107.144824
  24. Sugimoto T, Tanigawa T, Onishi K, et al. Serum intact parathyroid hormone levels predict hospitalization for heart failure. Heart. 2009;95:395-398.  https://doi.org/10.1136/hrt.2008.147652
  25. Pérez de Ciriza C, Lawrie A, Varo N. Osteoprotegerin in cardiometabolic disorders. International Journal of Endocrinology. 2015;15.  https://doi.org/10.1155/2015/564934
  26. Morisawa T, Nakagomi A, Kohashi K, et al. Osteoprotegerin is associated with endothelial function and predicts early carotid atherosclerosis in patients with coronary artery disease. International Heart Journal. 2015;56(6):605-612.  https://doi.org/10.1536/ihj.15-150
  27. Sbarouni E, Georgiadou P, Chatzikyriakou S, et al. Osteopontin in relation to Prognosis following Coronary Artery Bypass Graft Surgery. Disease Markers. 2016:5.  https://doi.org/10.1155/2016/1868739
  28. Ferencik M, Chatzizisis YS. Statins and the coronary plaque «calcium paradox»: Insights from non-invasive and invasive imaging. Atherosclerosis. 2015;241:783-785.  https://doi.org/10.1016/j.atherosclerosis.2015.05.021
  29. Reaber L, Taniwaki M, Zaugg S, et al. Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study. Eur Heart J. 2015;36:490-500.  https://doi.org/10.1093/eurheartj/ehu373
  30. Puri R, Nicholls SJ, Shao M, et al. Impact of statins on serial coronary calcification during atheroma progression and regression. J Am Coll Cardiol. 2015;65:273-1282. https://doi.org/10.1016/j.jacc.2015.01.036
  31. Black DM, Rosen CJ. Postmenopausal Osteoporosis. NEJM. 2016;374(3):254-262.  https://doi.org/10.1056/NEJMcp1513724
  32. https://doi.org/10.17802/2306-1278-2018-7-4-33-40  https://doi.org/10.17802/2306-1278-2018-7-4-33-40
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