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Barbarash O.L.

Research Institute for Complex Issues of Cardiovascular Diseases

Khryachkova O.N.

Research Institute for Complex Issues of Cardiovascular Diseases

Novitskaya A.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Zykov M.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Sedykh D.Yu.

Research Institute for Complex Issues of Cardiovascular Diseases

Kashtalap V.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Shibanova I.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Prognostic role of biological markers of bone metabolism in patients with coronary artery disease after coronary artery bypass grafting

Authors:

Barbarash O.L., Khryachkova O.N., Novitskaya A.A., Zykov M.V., Sedykh D.Yu., Kashtalap V.V., Shibanova I.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(6): 481‑488

DOI: 10.17116/kardio202013061481

Views: 976

Downloaded: 34

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Table of contents

PROGNOSTIC ROLE OF BIOLOGICAL MARKERS OF BONE METABOLISM IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER CORONARY ARTERY BYPASS GRAFTING
PROGNOSTIC ROLE OF BIOLOGICAL MARKERS OF BONE METABOLISM IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER CORONARY ARTERY BYPASS GRAFTING

To cite this article:

Barbarash OL, Khryachkova ON, Novitskaya AA, Zykov MV, Sedykh DYu, Kashtalap VV, Shibanova IA. Prognostic role of biological markers of bone metabolism in patients with coronary artery disease after coronary artery bypass grafting. Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(6):481‑488. (In Russ.)
https://doi.org/10.17116/kardio202013061481

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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OBJECTIVE

To evaluate the role of traditional risk factors and biological markers of osteo-coronary comorbidity for the prognosis in patients with coronary artery disease after coronary artery bypass surgery.

MATERIAL AND METHODS

The study included 111 men under the age of 75 years with coronary artery disease and angina pectoris CCS class I—III who underwent coronary artery bypass surgery. We have assessed the incidence of endpoints (death, myocardial infarction, recurrence/aggravation of angina attacks), risk factors and predictors of poor prognosis in patients with and without cardiovascular events within 3 years after surgery.

RESULTS

After 3 years, 21 (22.1%) patients developed adverse outcomes. Patients with cardiovascular events were characterized by high smoking rate (p=0.050), high biomarkers of bone resorption (alkaline phosphatase (p=0.030), osteocalcin (p=0.010) osteopontin (p=0.040)), low levels of osteoprotegerin (p=0.020). Postoperative period was characterized by negative dynamics of proatherogenic lipid factors. The predictors of adverse outcomes within 3 years after coronary artery bypass surgery were high osteopontin level (>8.3 ng/ml, p=0.023), smoking (p=0.050), high parathyroid hormone (>49.1 pg/ml, p=0.014), osteocalcin (>26.8 ng/ml, p=0.020), alkaline phosphatase (>186 u/l, p=0.041). Moreover, high preoperative levels of osteocalcin (p=0.037) and parathyroid hormone (p=0.012) were significant factors with risk augmentation by 23.6% for one elevated factor and 75% for increase of both factors.

CONCLUSION

A three-year unfavorable prognosis of coronary artery bypass surgery is associated with increased preoperative osteocalcin, parathyroid hormone, osteopontin, alkaline phosphatase, smoking and negative lipid dynamics.

Keywords:

coronary artery bypass surgery
prognosis
biological markers
osteo-coronary comorbidity

Authors:

Barbarash O.L.

Research Institute for Complex Issues of Cardiovascular Diseases

Khryachkova O.N.

Research Institute for Complex Issues of Cardiovascular Diseases

Novitskaya A.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Zykov M.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Sedykh D.Yu.

Research Institute for Complex Issues of Cardiovascular Diseases

Kashtalap V.V.

Research Institute for Complex Issues of Cardiovascular Diseases

Shibanova I.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Received:

18.05.2020

Accepted:

03.06.2020

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