Objective. To analyze the predictors of adverse outcomes in patients with peripheral atherosclerosis (PA) within 3-year outpatient follow-up. Material and methods. The data of 585 patients with PA who were under outpatient follow-up for the period from 2010 to 2017 were analyzed. The first group included 72 patients with adverse outcomes (death, nonfatal myocardial infarction and stroke, limb amputation). The second group consisted of 513 patients with a relatively favorable course of disease. Mean follow-up period was 3 years. The groups were compared according to the main demographic, laboratory and instrumental examination data. Results. Angina pectoris class II was more common in group 1 (p<0.05). Cardiologist followed-up 79.6% of patients in group 2 and 63.6% of patients in group 1. In the first group, there were significantly more patients with stenosis >70% of lower limb arteries (p<0.01), chronic lower limb ischemia grade 4 (p<0.05) and previous amputation (p<0.01). 40.3% and 61.4% of patients in both groups visited vascular surgeon (p<0.001). Predictors of favorable prognosis were follow-up by cardiologist (p<0.001), statins (p<0.001) and aspirin (p<0.001) intake and observation at the day hospital (p=0.02). Predictors of unfavorable outcome were previous amputation (p=0.003), angina class II (p<0.001) and previous coronary artery stenting (p<0.001). Conclusion. Independent predictors of adverse outcome were angina pectoris, previous amputation. Predictors of favorable outcomes were follow-up by cardiologist, statins and aspirin intake.