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Kalinin R.E.

Pavlov Ryazan State Medical University

Suchkov I.A.

Pavlov Ryazan State Medical University

Mzhavanadze N.D.

Pavlov Ryazan State Medical University

Povarov V.O.

Pavlov Ryazan State Medical University

Trebunskikh E.A.

Pavlov Ryazan State Medical University

Predictors of myocardial infarction in patients with stable peripheral artery disease

Authors:

Kalinin R.E., Suchkov I.A., Mzhavanadze N.D., Povarov V.O., Trebunskikh E.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(1): 61‑65

DOI: 10.17116/kardio20251801161

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Table of contents

PREDICTORS OF MYOCARDIAL INFARCTION IN PATIENTS WITH STABLE PERIPHERAL ARTERY DISEASE
PREDICTORS OF MYOCARDIAL INFARCTION IN PATIENTS WITH STABLE PERIPHERAL ARTERY DISEASE

To cite this article:

Kalinin RE, Suchkov IA, Mzhavanadze ND, Povarov VO, Trebunskikh EA. Predictors of myocardial infarction in patients with stable peripheral artery disease. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(1):61‑65. (In Russ.)
https://doi.org/10.17116/kardio20251801161

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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OBJECTIVE

To study blood clotting factors (von Willebrand factor, factors VIII, IX, XI) as possible predictors of unfavorable outcomes, particularly, myocardial infarction, in patients with chronic lower limb ischemia due to stable peripheral artery disease.

MATERIAL AND METHODS

The study included 52 patients, median age was 61 (55; 66) years; 42 (82.7%) patients were male. Within a year, 3 (6%) patients were newly diagnosed with cancer; 4 (8%) patients developed myocardial infarction. There were no cases of lower limb thrombosis, stroke or lethal outcomes.

RESULTS

VWF and factor IX activity was increased up to 300% (160; 300) and 175% (124; 239), respectively. However, it was not associated with any of the aforementioned outcomes (p>0.05). Subjects with factor XI activity over 142% had a 9-fold higher risk of myocardial infarction (RR 9, CI 95% 1.023—79.171). Patients with previous myocardial infarction had a 2.6-fold higher risk of repeated infarction within a year (RR 2.6, CI 95% 1.031—6.599).

CONCLUSION

In patients with stable peripheral atherosclerosis, activity of vWF and factor IX is increased. The probability of acute myocardial infarction in patients with intermittent claudication depends on baseline activity of factor XI (higher activity of factor XI means higher probability of myocardial infarction). Previous infarction in patients with peripheral atherosclerosis increases the risk of recurrent myocardial infarction.

Keywords:

intermittent claudication
peripheral artery disease
myocardial infarction
outcomes
predictors

Authors:

Kalinin R.E.

Pavlov Ryazan State Medical University

Suchkov I.A.

Pavlov Ryazan State Medical University

Mzhavanadze N.D.

Pavlov Ryazan State Medical University

Povarov V.O.

Pavlov Ryazan State Medical University

Trebunskikh E.A.

Pavlov Ryazan State Medical University

Received:

10.05.2023

Accepted:

02.06.2023

List of references:

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