Objective — prospective testing of a computer program for selecting the optimal surgical strategy of revascularization in patients with combined lesion of carotid and coronary arteries. Material and methods. Considering our previous researches in 2012—2015, we developed a model for personalized choice of the optimal strategy for myocardial and cerebral revascularization. This model is based on prediction of the risk of adverse ischemic cardiovascular events in long-term follow-up period (within 34±12.1 months). At the next stage, we created a computer program allowing determination of the risk of complications in numerical and qualitative form for different surgical strategies. This program was used to determine prospectively the optimal surgical strategy in 108 patients for the period 2017—2018. Results. Automatized system fully supported the decision of multidisciplinary team in 13% of patients with significant adverse postoperative cardiovascular events. In 71% of cases, council’s decision was supported, but an alternative strategy with similar or less risk was proposed. Another approach was proposed in 16% of cases. Complete concordance of the decisions of surgical team and calculator data was observed in 10% among patients without postoperative complications. Council’s decision was supported, but an alternative strategy was proposed in 82% of cases. Different strategy was proposed in 8% of patients. Thus, coincidence of calculations and solutions was observed in 84% of patients with complicated course of follow-up period and in 92% patients without complications. Conclusion. High compliance of automated system data for selecting the optimal surgical strategy was found during its testing in a prospective mode. High potential of the program in improving the outcomes of surgical treatment of high-risk patients with atherosclerosis of coronary and carotid arteries was shown.