Impact of atrial fibrillation on left ventricle and activity of systemic inflammation

Strakhova K.V.; Kazakova N.Iu.; Belikova I.V.; Egorova E.N.; Kinakh T.A.; Mazur V.V.; Mazur E.S.

doi:https://doi.org/

Strakhova K.V.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Kazakova N.Iu.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Belikova I.V.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Egorova E.N.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Kinakh T.A.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Mazur V.V.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Mazur E.S.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Impact of atrial fibrillation on left ventricle and activity of systemic inflammation

Authors:

Strakhova K.V., Kazakova N.Iu., Belikova I.V., Egorova E.N., Kinakh T.A., Mazur V.V., Mazur E.S.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(4): 79‑83

Read: 1095 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Strakhova KV, Kazakova NIu, Belikova IV, Egorova EN, Kinakh TA, Mazur VV, Mazur ES. Impact of atrial fibrillation on left ventricle and activity of systemic inflammation. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(4):79‑83. (In Russ.)

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Immediate results of mitral and aortic valve replacement with simultaneous Cox-Maze IV procedure. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(1):28-33

Obstructive sleep apnea syndrome as a predictor of atrial fibrillation. Russian Journal of Preventive Medicine. 2025;(1):109-114

Chronic inflammation in case of obesity-associated diseases. Russian Journal of Preventive Medicine. 2025;(1):115-121

Arterial hypertension is an oxidative stress, as a pathogenetic target for the treatment of chronic cerebrovascular insufficiency. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):84-90

Characteristics of the myocardial structural and functional parameters depending on the metabolic phenotype of the Arkhangelsk city residents. Russian Journal of Preventive Medicine. 2025;(2):53-60

The Relationship of obstructive sleep apnea with paroxysmal atrial fibrillation in women suffered coronary heart disease and arterial hypertension. Russian Journal of Preventive Medicine. 2025;(2):61-66

Dynamics of arterial stiffness indicators during antihypertensive therapy. Russian Journal of Preventive Medicine. 2025;(2):74-79

Prevalence of cerebrovascular diseases risk factors according to the cohort survey data in Bishkek, Kyrgyz Republic. Russian Journal of Preventive Medicine. 2025;(3):34-39

Associations between the gut microbiota-derived metabolites with the parameters of 24-hour ambulatory blood pressure monitoring in patients on maintenance hemodialysis. Russian Journal of Preventive Medicine. 2025;(3):96-102

Short-chain fatty acid profile in patients undergoing maintenance hemodialysis. Russian Journal of Evidence-Based Gastroenterology. 2025;(1):47-54

Abstract:

Successful cardioversion was carried out in 87 patients with persistent atrial fibrillation (AF); among them 42 didn't have functional disturbances of left ventricle (1 group), 25 had left ventricular diastolic dysfunction (2 group), 20 - systolic and diastolic dysfunction (3 group). After sinus rhythm restoration statistically significant increase in 6-minute walk test distance (by 44±7, 35±5 и 77±8 м respectively), decrease of NT-proBNP (by 420±87, 396±115 и 660±136 pg/ml), endotoxin (by 0,08±0,01, 0,07±0,02 и 0,12±0,03 unit/ml) and TNF-α levels (by 2,99±0,38, 1,47±0,21 и 3,07±0,77 pg/ml), decrease of left ventricular (by 12,4±1,8, 16,8±4,0 и 37,3±6,7 ml) and right atrium (by 8,2±2,0, 10,8±3,2 и 27,8±6,6 ml) volumes and systolic (by 2,9±0,4, 3,6±0,4 и 7,9±1,2 mm Hg) and diastolic (1,8±0,2, 2,6±0,5 и 4,2±1,0 mm Hg) pressures in pulmonary artery were observed in all groups. Along with this statistically significant decrease of left ventricular end-diastolic volume (by15,4±2,2 ml), increase of ejection fraction (by 9,1±1,1%) and velocity of early diastolic filling wave (by 13,7±3,0 cm/s). It is drawn a conclusion that transient systolic and diastolic dysfunction can be present in atrial fibrillation. Regardless of left ventricular condition atrial fibrillation leads to decreased physical capacity, increase in NT-proBNP level, increase of right atrium volume, pulmonary artery pressure and levels of endotoxin and TNF-α in blood.

Keywords:

atrial fibrillation

arterial hypertension

left ventricular dysfunction

systemic inflammation

Authors:

Strakhova K.V.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Kazakova N.Iu.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Belikova I.V.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Egorova E.N.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Kinakh T.A.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Mazur V.V.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Mazur E.S.

GOU VPO Tverskaia GMA Minzdravsotsrazvitiia Rossii

Close metadata

References:

Arutyunov G.P., Kafarskaya L.I., Vlasenko V.K. Biotsenoz kishechnika i serdechno-sosudistyi kontinuum. Serdechnaya nedostatochnost' 2004; 5: 224-229.
Arutyunov G.P., Kafarskaya L.I., Bylova N.A. i dr. Kachestvennye i kolichestvennye pokazateli mikroflory tolstogo kishechnika pri razlichnykh funktsional'nykh klassakh khronicheskoi serdechnoi nedostatochnosti. Serdechnaya nedostatochnost' 2005; 5: 176-180.
Vasyuk Yu.A., Khadzegova A.B., Ivanova S.V. Strukturno-funktsional'nye izmeneniya pravogo zheludochka pri arterial'noi gipertenzii - prichina ili sledstvie khronicheskoi serdechnoi nedostatochnosti? Serdechnaya nedostatochnost' 2005; 3: 117-119.
Veber V.R., Rubanova M.P., Zhmailova S.V., Kopina M.N. Diastolicheskaya disfunktsiya levogo i pravogo zheludochka u bol'nykh arterial'noi gipertoniei i vozmozhnosti ee korrektsii. Serdechnaya nedostatochnost' 2005; 3: 107-109.
Volkov V.I., Salamekh Kh.N., Serik S.A. Pro- i protivovospalitel'nye tsitokiny pri serdechnoi nedostatochnosti. Khar'kov 2007; 2: 23-28.
Dedkova A.A., Suslova T.E., Kologrivova I.V. i dr. Faktory vospaleniya i markery povrezhdeniya miokarda pri fibrillyatsii predserdii. Vestn aritmol 2010; 60: 49-53.
Diagnostika i lechenie fibrillyatsii predserdii. Natsional'nye klinicheskie rekomendatsii VNOK. M: Silitseya-Poligraf 2008; 475-508.
Diagnostika i lechenie khronicheskoi serdechnoi nedostatochnosti. Natsional'nye klinicheskie rekomendatsii. Serdechnaya nedostatochnost' 2010; 1: 3-62.
Egorova E.N., Kuz'mina M.A., Guminskii A.V. i dr. Dinamika endotoksinemii i urovnya faktora nekroza opukholi-α pri lechenii khronicheskoi serdechnoi nedostatochnosti. Serdechnaya nedostatochnost' 2009; 4: 167-168.
Egorova E.N., Kuz'mina M.I., Mazur V.V. i dr. Dinamika faktorov sistemnogo vospaleniya i aminokontsevogo mozgovogo natriiureticheskogo propeptida pri lechenii khronicheskoi serdechnoi nedostatochnosti. Ter arkh 2011; 1: 56-59.
Kushakovskii M.S. Fibrillyatsiya predserdii (prichiny, mekhanizmy, klinicheskie formy, lechenie i profilaktika). SPb: Foliant 1999.
Mitrofanova L.B., Kudaibergenova A.G., Antonova I.V. Fibrillyatsiya predserdii, amiloidoz, miokardit i virusnaya infektsiya. Arterial'naya gipertenziya 2009; 2: 203-208.
Ovchinnikov A.G., Svirida A.N., Ageev F.T. Sostoyanie diastolicheskoi funktsii u patsientov s khronicheskoi serdechnoi nedostatochnost'yu, s sokhranennoi sistolicheskoi funktsiei levogo zheludochka i mertsatel'noi aritmiei. Serdechnaya nedostatochnost' 2010; 6: 327-337.
Tarasova O.A. Rol' markerov vospaleniya pri fibrillyatsii predserdii. Vrach 2007; 1: 49-53.
Chernova A.A., Starikova E.A., Sokolov D.I. i dr. Vliyanie produktov bakterial'nogo proiskhozhdeniya na ekspressiyu poverkhnostnykh molekul monotsitopodobnykh i endotelial'nykh kletok. Zhurn mikrobiol 2008; 4: 60-63.
Shiller N., Osipov M.A. Klinicheskaya ekhokardiografiya, vtoroe izdanie. M: Praktika 2005.
Allessie M., Ausma J., Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res 2002; 54: 230-246.
Aviles R.J., Martin D.O., Apperson-Hansen S. et al. Inflammation as a rick factor for atrial fibrillation. Circulation 2003; 108: 24: 3006-3010.
Engelmann M.D., Svedsen J.H. The emerging role of inflammation in atrial fibrillation and the potential of anti-inflammatory intervention: reply. Eur Heart J 2005; 26: 20: 2208-2209.
Fuster V., Ryden L.E., Asinger R.W. et al. ACC/AHA/ESC Guidelines for the Management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation). Eur Heart J 2001; 22:1852-1923.
Garcia M.J., Ares M.A., Asher C. et al. An index of early left ventricular filling that combined with pulsed Doppler peak E velocity may estimate capillary wedge pressure. J Am Coll Cardiol 1997; 29: 448-454.
Garcia M.J., Smedira N.G., Greenberg N.L. el al. Color M-mode Doppler flow propagation velocity is a preload insensitive index of left ventricular relaxation: animal and human validation. J Am Coll Cardiol 2000; 35: 1: 201-208.
Hernandez A. C-reactive protein and atrial fibrillation. An old marker looking for new target. Rev Esp Cardiol 2006; 59: 94-98.
Leone O., Boriani G., Chiappini B. et al. Amyloid deposition as a cause of atrial remodelling in persistent valvular atrial fibrillation. Eur Heart J 2004; 25: 1237-1241.
Morgan M.J., Kim Y-S., Liu Z. TNF-a and reactive oxygen species in necrotic cell death. Cell Res 2008; 18: 343-349.
Ouama R., Murata K., Tanaka N. et al. Is the ratio of transmitral peak E-wave velocity to color flow propagation velocity useful for evaluating the severity of heart failure in atrial fibrillation? Circulat J 2004; 68: 12: 1132-1138.
Rocken C., Peters V., Juenemann G. et al. Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation. Circulation 2002; 106: 2091-2097.
Sandek A., Bauditz J., Swidsinski A. et al. Altered Intestinal Function in Patients With Chronic Heart Failure. J Am Coll Cardiol 2007; 50: 16: 1561-1569.