Pathophysiological aspects of cerebral energy metabolism under conditions of systemic atherosclerosis and diabetes mellitus

Kamenskaia O.V.; Levicheva E.N.; Loginova I.Iu.; Karpenko A.A.

doi:https://doi.org/

Kamenskaia O.V.

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia RF

Levicheva E.N.

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia RF

Loginova I.Iu.

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia RF

Karpenko A.A.

Novosibirskiĭ NII patologii krovoobrashcheniia im. akad. E.N. Meshalkina;
Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks Minzdravsotsrazvitiia Rossii, Moskva

Pathophysiological aspects of cerebral energy metabolism under conditions of systemic atherosclerosis and diabetes mellitus

Authors:

Kamenskaia O.V., Levicheva E.N., Loginova I.Iu., Karpenko A.A.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(1): 60‑63

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To cite this article:

Kamenskaia OV, Levicheva EN, Loginova IIu, Karpenko AA. Pathophysiological aspects of cerebral energy metabolism under conditions of systemic atherosclerosis and diabetes mellitus. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(1):60‑63. (In Russ.)

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

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Abstract:

Mechanisms of cerebral energy metabolism were analyzed in patients with systemic atherosclerosis combined with diabetes mellitus. Basing on data of cerebral oxymetry, gases and electrolytes of arterial and venous blood, efficacy of glucose utilization cerebral energy status was estimated during carotid endarterectomy. It is shown that atherosclerosis in combination with disturbances in carbohydrate metabolism decreases the efficacy of cerebral energy metabolism. In patients with systemic atherosclerosis and diabetes mellitus decreased tonus of cerebral arteries and increased oxygen extraction from blood were registered in comparison with patients without diabetes indicating high depletion of gas-transport blood function for maintenance of effective oxygen supply to the brain. Moreover, efficacy of glucose utilization in patients with diabetes mellitus is two times below the norm despite high serum glucose level.

Keywords:

diabetes mellitus

atherosclerosis

brain

energy metabolism

cerebral ischemi

Authors:

Kamenskaia O.V.

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia RF

Levicheva E.N.

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia RF

Loginova I.Iu.

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia RF

Karpenko A.A.

Novosibirskiĭ NII patologii krovoobrashcheniia im. akad. E.N. Meshalkina;
Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks Minzdravsotsrazvitiia Rossii, Moskva

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