Surgical treatment of a patient with severe aortic stenosis and hereditary factor XI deficiency

Kozlova EV, Bulkina OS, Zozulya NI, et al. Surgical treatment of a patient with severe aortic stenosis and hereditary factor XI deficiency. Russian Cardiology Bulletin. 2025;20(4):88‑93. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20252004188

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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Abstract:

Surgery is the only effective treatment for severe aortic stenosis. Previously, valve replacement was only performed under cardiopulmonary bypass. Minimally invasive transcatheter aortic valve implantation (TAVI) is currently available for high-risk patients, including elderly ones. However, there is a risk of hemorrhagic complications even in minimally invasive procedures. In general population, the incidence of bleeding requiring transfusion after TAVI is 6—9%. The risk of bleeding is even higher in patients with clotting disorders. We present successful management of a patient with hereditary factor XI deficiency who required surgical treatment for severe symptomatic aortic stenosis.

Keywords:

hemophilia C

factor XI

transcatheter aortic valve implantation

aortic stenosis

Authors:

Kozlova E.V.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-6847-4080

Bulkina O.S.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0003-4773-6966

Zozulya N.I.

National Research Center for Hematology

SPIN RSCI: 4480-5590
Scopus AuthorID: 57219322107
ResearcherID: N-3151-2014
ORCID: 0000-0001-7074-0926

Lopukhova V.V.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-7667-9043

Komlev A.E.

Chazov National Research Center of Cardiology

ORCID: 0000-0001-6908-7472

Kolegaev A.S.

Chazov National Research Center of Cardiology

ORCID: 0000-0002-5054-1310

Maslennikova N.S.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-8232-1750

Imaev T.E.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-5736-5698

Karpov Yu.A.

National Medical Research Center for Cardiology

ORCID: 0000-0003-1480-0458

Received:

20.10.2025

Accepted:

21.10.2025

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References:

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