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Agafonov E.G.

Moscow Regional Research Clinical Institute

Zolotareva L.S.

Pirogov Russian National Research Medical University

Mameshova L.Zh.

Lomonosov Moscow State University

Zybin D.I.

Moscow Regional Research Clinical Institute

Popov M.A.

Moscow Regional Research Clinical Institute

Dontsov V.V.

Moscow Regional Research Clinical Institute

Pronina V.P.

Moscow Regional Research Clinical Institute

Maslennikov R.A.

Moscow Regional Research Clinical Institute

Marchenko L.Yu.

Institute of Biomedical Issues of the Russian Academy of Sciences

Sigaleva E.E.

Institute of Biomedical Issues of the Russian Academy of Sciences

Shumakov D.V.

Moscow Regional Research Clinical Institute

Helium-induced preconditioning and postconditioning in patients with myocardial ischemia

Authors:

Agafonov E.G., Zolotareva L.S., Mameshova L.Zh., Zybin D.I., Popov M.A., Dontsov V.V., Pronina V.P., Maslennikov R.A., Marchenko L.Yu., Sigaleva E.E., Shumakov D.V.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(2): 5‑12

DOI: 10.17116/Cardiobulletin2024190215

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To cite this article:

Agafonov EG, Zolotareva LS, Mameshova LZh, et al. . Helium-induced preconditioning and postconditioning in patients with myocardial ischemia. Russian Cardiology Bulletin. 2024;19(2):5‑12. (In Russ.)
https://doi.org/10.17116/Cardiobulletin2024190215

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Coronary artery disease is one of the most common causes of morbidity and mortality worldwide. Non-drug treatment provides direct restoration of blood supply in ischemic myocardial regions via interventional or surgical procedures. Searching for new methods for perioperative improvement of myocardial metabolism is now relevant. Noble gases are interesting for coronary artery disease due to their protective properties. Special attention is paid to helium due to its physical similarity in viscosity and penetrating power with air. Helium is present in various concentrations in inhalation helium-oxygen mixtures.

OBJECTIVE

To study the effects of inhalation of helium-oxygen mixtures for pre- (PreC) and post-conditioning (PostC).

MATERIAL AND METHODS

We reviewed Russian- and English-language publications in the Pubmed, Web of Science and RSCI databases.

RESULTS

According to 8 studies, inhalations of helium-oxygen mixture for PreC and PostC had cardiac protective effects on myocardial ischemia models in laboratory animals. There are few available data on the use of helium in real clinical cases. Various authors presented own results confirming or disproving protective properties of helium.

CONCLUSION

This problem is important, and further clinical studies are needed to investigate the possible role of helium in myocardial ischemia.

Keywords:

myocardial ischemia
helium
preconditioning
postconditioning
systematic review

Authors:

Agafonov E.G.

Moscow Regional Research Clinical Institute

Zolotareva L.S.

Pirogov Russian National Research Medical University

Mameshova L.Zh.

Lomonosov Moscow State University

Zybin D.I.

Moscow Regional Research Clinical Institute

Popov M.A.

Moscow Regional Research Clinical Institute

Dontsov V.V.

Moscow Regional Research Clinical Institute

Pronina V.P.

Moscow Regional Research Clinical Institute

Maslennikov R.A.

Moscow Regional Research Clinical Institute

Marchenko L.Yu.

Institute of Biomedical Issues of the Russian Academy of Sciences

Sigaleva E.E.

Institute of Biomedical Issues of the Russian Academy of Sciences

Shumakov D.V.

Moscow Regional Research Clinical Institute

Received:

25.09.2023

Accepted:

15.01.2024

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