Helium-induced preconditioning and postconditioning in patients with myocardial ischemia

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OBJECTIVE

To study the effects of inhalation of helium-oxygen mixtures for pre- (PreC) and post-conditioning (PostC).

MATERIAL AND METHODS

We reviewed Russian- and English-language publications in the Pubmed, Web of Science and RSCI databases.

RESULTS

According to 8 studies, inhalations of helium-oxygen mixture for PreC and PostC had cardiac protective effects on myocardial ischemia models in laboratory animals. There are few available data on the use of helium in real clinical cases. Various authors presented own results confirming or disproving protective properties of helium.

CONCLUSION

This problem is important, and further clinical studies are needed to investigate the possible role of helium in myocardial ischemia.

Keywords:

myocardial ischemia

helium

preconditioning

postconditioning

systematic review

Authors:

Agafonov E.G.

Moscow Regional Research Clinical Institute

ORCID: 0000-0002-6074-1201

Zolotareva L.S.

Pirogov Russian National Research Medical University

ORCID: 0000-0001-7662-8257

Mameshova L.Zh.

Lomonosov Moscow State University

ORCID: 0000-0001-9965-0641

Zybin D.I.

Moscow Regional Research Clinical Institute

ORCID: 0000-0001-7087-5441

Popov M.A.

Moscow Regional Research Clinical Institute

ORCID: 0000-0002-0316-8410

Dontsov V.V.

Moscow Regional Research Clinical Institute

ORCID: 0000-0003-2904-5213

Pronina V.P.

Moscow Regional Research Clinical Institute

ORCID: 0000-0002-2348-1500

Maslennikov R.A.

Moscow Regional Research Clinical Institute

ORCID: 0009-0003-6143-9164

Marchenko L.Yu.

Institute of Biomedical Issues of the Russian Academy of Sciences

ORCID: 0000-0001-9925-1413

Sigaleva E.E.

Institute of Biomedical Issues of the Russian Academy of Sciences

ORCID: 0000-0001-9899-1604

Shumakov D.V.

Moscow Regional Research Clinical Institute

ORCID: 0000-0003-4204-8865

Received:

25.09.2023

Accepted:

15.01.2024

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