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Zubkova E.S.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Dergilev K.V.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Guseva A.A.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Ratner E.I.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Menshikov M.Yu.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Parfenova Ye.V.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov;
Lomonosov Moscow State University

Secretory activity of epicardial and adipose mesenchymal cells in pro-inflammatory and anti-inflammatory microenvironment

Authors:

Zubkova E.S., Dergilev K.V., Guseva A.A., Ratner E.I., Menshikov M.Yu., Parfenova Ye.V.

More about the authors

Journal: Russian Cardiology Bulletin. 2022;17(4): 38‑45

DOI: 10.17116/Cardiobulletin20221704138

Read: 1426 times

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Table of contents

SECRETORY ACTIVITY OF EPICARDIAL AND ADIPOSE MESENCHYMAL CELLS IN PRO-INFLAMMATORY AND ANTI-INFLAMMATORY MICROENVIRONMENT
SECRETORY ACTIVITY OF EPICARDIAL AND ADIPOSE MESENCHYMAL CELLS IN PRO-INFLAMMATORY AND ANTI-INFLAMMATORY MICROENVIRONMENT

To cite this article:

Zubkova ES, Dergilev KV, Guseva AA, Ratner EI, Menshikov MYu, Parfenova YeV. Secretory activity of epicardial and adipose mesenchymal cells in pro-inflammatory and anti-inflammatory microenvironment. Russian Cardiology Bulletin. 2022;17(4):38‑45. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221704138

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the influence of controlled microenvironment factors on secretory activity of epicardial and adipose mesenchymal cells.

RESULTS

We found that epicardial and adipose mesenchymal cells were characterized by active secretion of growth factors (FGF2 and VEGF, inflammatory cell differentiation factors G-CSF and GM-CSF, inflammatory mediators MCP1 MCP3, RANTES, IL6, IL8). Release of anti-inflammatory interleukins IL4, IL13, IL1Ra, was moderate or low. In general, release of most factors was more active in epicardial mesenchymal cells. Nevertheless, adipose mesenchymal cells had more pronounced response to interleukin-4 (IL4), tumor necrosis factor (TNF) and pathogen-associated molecular patterns (PAMPs), i.e. lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid (p(I:C)).

CONCLUSION

We revealed significant differences in secretory activity and regulation ability between epicardial and adipose mesenchymal cells. These differences determine specificity of molecular mechanisms mediating these processes. The findings expand understanding of reparative properties of epicardium and can be used in development of approaches to the treatment of heart diseases.

Keywords:

epicardium
mesenchymal stem cells
epithelial-mesenchymal transition
cytokines
growth factors
secretion
inflammation

Authors:

Zubkova E.S.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Dergilev K.V.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Guseva A.A.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Ratner E.I.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Menshikov M.Yu.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov

Parfenova Ye.V.

Chazov National Medical Research Center of Cardiology named after academician E.I. Chazov;
Lomonosov Moscow State University

Received:

11.10.2022

Accepted:

19.10.2022

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References:

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