Objective. To evaluate the early and one-year outcomes after coronary artery bypass grafting (CABG) with microsurgical technique in patients with diffuse coronary artery disease. Material and methods. Patients who underwent isolated CABG surgery for multivessel coronary disease in 2014 year were enrolled in the study. Each distal anastomosis was performed with use of the surgical microscope. The angiographic data was analyzed in preoperative period. 89 patients with diffuse coronary artery disease formed the first group. The second group included 258 patients with proximal lesions. Adjunct techniques (endarterectomy, onlay-patch technique, anastomosis to small arteries (<1.5 mm in diameter) were widely used in diffuse cases and standard approach was used in other cases. We compared preoperative clinical status as well as in-hospital and one-year outcomes between groups. The outcomes were angina recurrence, myocardial infarction, repeat revascularization and cardiac mortality. Composite endpoint was used in statistical analysis. Results. Preoperative clinical status was comparable in both groups. In-hospital outcomes differed in the number of patients needed for inotropic support (20% vs. 12% in groups 1 and 2 respectively, p<0.05). The incidence of composite endpoint 1 year after surgery was comparable in both groups (13% vs. 9%, p=0.57). Conclusion. CABG with adjunct techniques and surgical microscope in patients with diffuse coronary artery disease provides the same in-hospital and one-year outcomes as in patients having proximal lesions and operated with standard approach.