Hypersensitivity Skin Reactions After Cyanoacrylate Adhesive Closure of Varicose Veins: 5-Year Treatment Outcomes

Shirinbek O.; Mnatsakanyan G.V.; Odinokova S.N.

doi:https://doi.org/10.17116/flebo20262001142

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OBJECTIVE

To assess the incidence and risk factors for the development of cyanoacrylate adhesive-induced DHSR in patients with LEVVs.

MATERIAL AND METHODS

A retrospective analysis of data on patients with LEVVs who underwent CAC of the main saphenous veins was performed. An assessment of potential risk factors for the development of DHSR, including sex, age, body mass index and length of the obliterated segment, was done. The criterion for DHSR was the presence of at least one of the following symptoms in the projection of the obliterated vein: hyperemia (erythema), pain/tenderness, local sensation of heat, skin itching, as well as low-grade fever and urticaria. Multiple logistic regression analysis was used to identify risk factors for the development of DHSR.

RESULTS

During the reporting period, CAC was performed in 1794 patients, the total number of procedures was 2729. The majority were women — 1179 (65.7%). The mean age of patients was 61±15 (from 25 to 93) years. DHSR after CAC in the postoperative period was reported in 186 (10.4%) subjects that, in relation to the number of performed interventions, amounted to 6.8%. The reaction developed in the absolute majority of cases within a period of 7 days to one year after the intervention with a median of 16 (interquartile range 10—24) days. Among the potential risk factors for the development of DHSR, the length of of the obliterated segment demonstrated a statistically significant advantage according to the results of the corresponding analysis — odds ratio 2.40 (95% CI 1.98—2.91).

CONCLUSION

DHSR is a common adverse event after adhesive closure. The length of obliteration is an independent risk factor for the development of this complication. Successful relief of this reaction through conservative treatment demonstrates the manageability of DHSR occurrence.

Keywords:

lower extremity varicose veins

cyanoacrylate adhesive closure

adverse events

delayed hypersensitivity skin reaction

phlebitic reaction

phlebitis-like reaction

Authors:

Shirinbek O.

SM-Clinic Multidisciplinary Medical Holding Company — Phlebology Center, Moscow, Russia

Scopus AuthorID: 57566072700
ORCID: 0000-0003-2116-2247

Mnatsakanyan G.V.

SM-Clinic Multidisciplinary Medical Holding Company — Phlebology Center, Moscow, Russia;
National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

ORCID: 0000-0001-8402-4381

Odinokova S.N.

Sklifosovsky Institute of Clinical Medicine of the Sechenov First Moscow State Medical University, Moscow, Russia

SPIN RSCI: 5416-5379
Scopus AuthorID: 57214320789
ORCID: 0000-0002-5403-8456

Received:

24.08.2025

Accepted:

27.01.2026

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References:

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