Venous thromboembolism (VTE) is an important problem for public healthcare systems. Deep vein thrombosis (DVT) of the lower extremities leads to post-thrombotic syndrome (PTS) in 20—50% of cases. Endovascular management of DVT in patients with iliofemoral thrombosis reduces the risk of severe forms of PTS. There are various endovascular procedures including catheter-directed thrombolysis (CDT), mechanical thrombectomy (MT), and their combination. Such interventions require a multidisciplinary approach and involvement of a surgeon. Despite the long history of investigations in this field, many questions are still unresolved, i.e. implantation of cava-filter, optimal venous access and device, anticoagulant agent in acute period. Venous stents in addition to CDT or MT can improve the outcomes. Primary patency rate among different types of venous stents is identical. The choice of stent type is still up to a surgeon and depends on economic affordability as a main limiting factor. Currently, there are no standardized protocols for such endovascular procedures. There are numerous characteristics complicating this process such as disease duration, anatomical features and technical capabilities of hospitals. It is also important to consider the economic aspect of such interventions, especially when combining multiple techniques (MT and stenting). Only a small percentage of patients are potentially eligible for endovascular treatment of DVT. Therefore, these interventions are advisable in hospitals with large number of such patients.