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Kuperin A.S.

Pirogov Russian National Research Medical University

Gusev L.L.

Pirogov Russian National Research Medical University

Alukhanyan O.A.

Pirogov Russian National Research Medical University

Seliverstov E.I.

Pirogov Russian National Research Medical University

Lebedev I.S.

Pirogov Russian National Research Medical University

Endovascular Management of Iliofemoral Deep Vein Thrombosis

Authors:

Kuperin A.S., Gusev L.L., Alukhanyan O.A., Seliverstov E.I., Lebedev I.S.

More about the authors

Journal: Journal of Venous Disorders. 2024;18(1): 64‑71

Read: 2008 times


To cite this article:

Kuperin AS, Gusev LL, Alukhanyan OA, Seliverstov EI, Lebedev IS. Endovascular Management of Iliofemoral Deep Vein Thrombosis. Journal of Venous Disorders. 2024;18(1):64‑71. (In Russ.)
https://doi.org/10.17116/flebo20241801164

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References:

  1. Heit JA. Epidemiology of venous thromboembolism. Nat Rev Cardiol. 2015; 12(8):464-474.  https://doi.org/10.1038/nrcardio.2015.83
  2. Katel’nitskiy II, Nemirovich MV, Prostov II, Livadnyaya ES. Justification of Choice of Thromboprophylaxis Method in Patients with High-Risk Surgical Profile: A Literature Review. IP Pavlov Russian Medical Biological Herald. 2022;30(2):279-286.  https://doi.org/10.17816/PAVLOVJ65252
  3. Monreal M, Agnelli G, Chuang LH, Cohen AT, Gumbs PD, Bauersachs R, Mismetti P, Gitt AK, Kroep S, Willich SN, Van Hout B. Deep Vein Thrombosis in Europe — Health-Related Quality of Life and Mortality. Clinical and Applied Thrombosis/Hemostasis. 2019;25:107602961988394. https://doi.org/10.1177/1076029619883946
  4. Terekhovskaya YV, Akhmedova NE kyzy, Leonenko DI, Nikulina NN. Prognosis for Patients after Pulmonary Embolism and its Determining Factors (Results of 12-Month Follow-Up). IP Pavlov Russian Medical Biological Herald. 2023;31(1):49-58.  https://doi.org/10.17816/PAVLOVJ165196
  5. Kahn SR. The post-thrombotic syndrome. Hematology Am Soc Hematol Educ Program. 2016;2016(1):413-418.  https://doi.org/10.1182/asheducation-2016.1.413
  6. Kahn SR, Shbaklo H, Lamping DL, Holcroft CA, Shrier I, Miron MJ, Roussin A, Desmarais S, Joyal F, Kassis J, Solymoss S, Desjardins L, Johri M, Ginsberg JS. Determinants of health‐related quality of life during the 2 years following deep vein thrombosis. Journal of Thrombosis and Haemostasis. 2008;6(7):1105-1112. https://doi.org/10.1111/j.1538-7836.2008.03002.x
  7. Kolluri R, Lugli M, Villalba L, Varcoe R, Maleti O, Gallardo F, Black S, Forgues F, Lichtenberg M, Hinahara J, Ramakrishnan S, Beckman JA. An estimate of the economic burden of venous leg ulcers associated with deep venous disease. Vascular Medicine. 2022;27(1):63-72.  https://doi.org/10.1177/1358863X211028298
  8. Fedorov SA, Medvedev AP, Tselousova LM, Kudykin MN, Pichugin VV, Zhurko SA, Chiginev VA, Gamzaev AB, Trofimov NA, Gamayunov SV, Deryabin RA. Differential Approach to Surgical and Endovascular Treatments of Pulmonary Thromboembolism in Patients with Neurological and Neurosurgical Problems. IP Pavlov Russian Medical Biological Herald. 2022;30(2):223-232.  https://doi.org/10.17816/PAVLOVJ88671
  9. Bezlepkin YuA, Sonkin IN, Gusinsky AV, Fionik OV, Solntsev VN, Melnik VYu. Comparison of Long-Term Outcomes of Regional Catheter Thrombolysis and Standard Conservative Treatment for Proximal Deep Vein Thrombosis of Lower Extremities. Flebologiia. 2020;14(1):10.  https://doi.org/10.17116/flebo20201401110
  10. Vedantham S. The Attract Trial: A Step Forward for Evidence Based DVT Care. European Journal of Vascular and Endovascular Surgery. 2018;56(3): 320-321.  https://doi.org/10.1016/j.ejvs.2018.05.005
  11. Diniz J, Coelho A, Mansilha A. Endovascular treatment of iliofemoral deep venous thrombosis: is there enough evidence to support it? A systematic review with meta-analysis. International Angiology. 2020;39(2):93-104.  https://doi.org/10.23736/S0392-9590.19.04298-6
  12. Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, Sacks D, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators. Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis. New England Journal of Medicine. 2017;377(23):2240-2252. https://doi.org/10.1056/NEJMoa1615066
  13. Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, Huisman M, King CS, Morris TA, Sood N, Stevens SM, Vintch JRE, Wells P, Woller SC, Moores L. Antithrombotic Therapy for VTE Disease. Chest. 2016;149(2):315-352.  https://doi.org/10.1016/j.chest.2015.11.026
  14. Midulla M, Chevallier O, Comby PO, Giordano G, Pescatori LC, Falvo N, van den Berg JC, Cariati M, Loffroy R. Endovascular management of the deep venous thrombosis: A new challenging role for the endovascular specialist in 2020. Catheterization and Cardiovascular Interventions. 2021;98(4): 748-755.  https://doi.org/10.1002/ccd.29375
  15. Venous thromboembolic diseases: diagnosis, management and thrombophilia testing. National Institute for Health and Care Excellence (NICE). London: National Institute for Health and Care Excellence (NICE); 2023.
  16. Vedantham S, Desai KR, Weinberg I, Marston W, Winokur R, Patel S, Kolli KP, Azene E, Nelson K. Society of Interventional Radiology Position Statement on the Endovascular Management of Acute Iliofemoral Deep Vein Thrombosis. Journal of Vascular and Interventional Radiology. 2023;34(2):284-299.  https://doi.org/10.1016/j.jvir.2022.10.038
  17. Needleman L, Cronan JJ, Lilly MP, Merli GJ, Adhikari S, Hertzberg BS, DeJong MR, Streiff MB, Meissner MH. Ultrasound for Lower Extremity Deep Venous Thrombosis. Circulation. 2018;137(14):1505-1515. https://doi.org/10.1161/CIRCULATIONAHA.117.030687
  18. Loud PA, Grossman ZD, Klippenstein DL, Ray CE. Combined CT venography and pulmonary angiography: a new diagnostic technique for suspected thromboembolic disease. American Journal of Roentgenology. 1998; 170(4):951-954.  https://doi.org/10.2214/ajr.170.4.9530042
  19. Yankelevitz DF, Gamsu G, Shah A, Rademaker J, Shaham D, Buckshee N, Cham MD, Henschke CI. Optimization of Combined CT Pulmonary Angiography with Lower Extremity CT Venography. American Journal of Roentgenology. 2000;174(1):67-69.  https://doi.org/10.2214/ajr.174.1.1740067
  20. Jeong MJ, Kwon H, Noh M, Ko GY, Gwon DI, Lee JS, Kim MJ, Choi JY, Han Y, Kwon TW, Cho YP. Relationship of Lower-extremity Deep Venous Thrombosis Density at CT Venography to Acute Pulmonary Embolism and the Risk of Postthrombotic Syndrome. Radiology. 2019;293(3):687-694.  https://doi.org/10.1148/radiol.2019190358
  21. Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Density of Thrombus on Admission CT Predicts Revascularization Efficacy in Large Vessel Occlusion Acute Ischemic Stroke. Stroke. 2013;44(1):243-245.  https://doi.org/10.1161/STROKEAHA.112.674127
  22. Garg K, Kemp JL, Russ PD, Barón AE. Thromboembolic Disease. American Journal of Roentgenology. 2001;176(4):1043-1047. https://doi.org/10.2214/ajr.176.4.1761043
  23. Wildberger JE, Mahnken AH, Sinha AM, Stargardt A, Haage P, Schaller S, Günther RW. Abklärung von Lungenembolie und venöser Thromboembolie mittels Mehrschicht-Spiral CT. RöFo — Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 2002;174(3):301-307.  https://doi.org/10.1055/s-2002-20607
  24. Shamaki GR, Soji-Ayoade D, Adedokun SD, Kesiena O, Favour M, Bolaji O, Ezeh EO, Okoh N, Sadiq AA, Baldawi H, Davis A, Bob-Manuel T. Endovascular Venous Interventions — A State-of-the-Art Review. Curr Probl Cardiol. 2023;48(3):101534. https://doi.org/10.1016/j.cpcardiol.2022.101534
  25. Bashir R, Zack CJ, Zhao H, Comerota AJ, Bove AA. Comparative Outcomes of Catheter-Directed Thrombolysis Plus Anticoagulation vs Anticoagulation Alone to Treat Lower-Extremity Proximal Deep Vein Thrombosis. JAMA Intern Med. 2014;174(9):1494. https://doi.org/10.1001/jamainternmed.2014.3415
  26. Lichtenberg MKW, Stahlhoff S, Młyńczak K, Golicki D, Gagne P, Razavi MK, de Graaf R, Kolluri R, Kolasa K. Endovascular mechanical thrombectomy versus thrombolysis in patients with iliofemoral deep vein thrombosis — a systematic review and meta-analysis. Vasa. 2021;50(1):59-67.  https://doi.org/10.1024/0301-1526/a000875
  27. Lindsey P, Echeverria A, Poi MJ, Matos J, Bechara CF, Cheung M, Lin PH. Thromboembolic Risk of Endovascular Intervention for Lower Extremity Deep Venous Thrombosis. Ann Vasc Surg. 2018;49:247-254.  https://doi.org/10.1016/j.avsg.2017.10.004
  28. Yamagami T, Yoshimatsu R, Matsumoto T, Nishimura T. Prophylactic implantation of inferior vena cava filter during endovascular therapies for deep venous thrombosis of the lower extremity: is it necessary? Acta radiol. 2008;49(4):391-397.  https://doi.org/10.1080/02841850801886117
  29. Kwon SH, Park SH, Oh JH, Song MG, Seo TS. Prophylactic Placement of an Inferior Vena Cava Filter During Aspiration Thrombectomy for Acute Deep Venous Thrombosis of the Lower Extremity. Vasc Endovascular Surg. 2016;50(4):270-276.  https://doi.org/10.1177/1538574416644524
  30. Kaufman JA, Barnes GD, Chaer RA, Cuschieri J, Eberhardt RT, Johnson MS, Kuo WT, Murin S, Patel S, Rajasekhar A, Weinberg I, Gillespie DL. Society of Interventional Radiology Clinical Practice Guideline for Inferior Vena Cava Filters in the Treatment of Patients with Venous Thromboembolic Disease. Journal of Vascular and Interventional Radiology. 2020;31(10):1529-1544. https://doi.org/10.1016/j.jvir.2020.06.014
  31. Midulla M, Chevallier O, Comby PO, Giordano G, Pescatori LC, Falvo N, van den Berg JC, Cariati M, Loffroy R. Endovascular management of the deep venous thrombosis: A new challenging role for the endovascular specialist in 2020. Catheterization and Cardiovascular Interventions. 2021;98(4):748-755.  https://doi.org/10.1002/ccd.29375
  32. Duan P-F, Ni C-F. Randomized study of different approaches for catheter-directed thrombolysis for lower-extremity acute deep venous thrombosis. Journal of the Formosan Medical Association. 2016;115(8):652-657.  https://doi.org/10.1016/j.jfma.2015.07.001
  33. Bredikhin RA, Kulov ZM, Akhmetzyanov RV, Volodyukhin MYu. Catheter-Directed Thrombolysis in the Complex Treatment of May-Thurner Syndrome Complicated by Iliofemoral Vein Thrombosis. Flebologiia. 2019;13(3):261.  https://doi.org/10.17116/flebo201913031261
  34. Huang T, Ding W, Jin Y, Jin J, Deng X, Liang L, Chen Z, Hong X. Multi-factor analysis of failure for modified single-session Angiojet rheolytic thrombectomy in treatment of acute iliofemoral venous thrombosis from iliac vein compression syndrome. Phlebology: The Journal of Venous Disease. 2023;38(2):96-102.  https://doi.org/10.1177/02683555221149587
  35. Yuriditsky E, Narula N, Jacobowitz GR, Moreira AL, Maldonado TS, Horowitz JM, Sadek M, Barfield ME, Rockman CB, Garg K. Histologic assessment of lower extremity deep vein thrombus from patients undergoing percutaneous mechanical thrombectomy. J Vasc Surg Venous Lymphat Disord. 2022;10(1):18-25.  https://doi.org/10.1016/j.jvsv.2021.03.010
  36. Li J, Chen H, Chen W, Zhou K, Xu Z, Xu M, Sun Z. Novel typing of iliac vein compression in asymptomatic individuals evaluated by contrast enhanced CT. Surgical and Radiologic Anatomy. 2021;43(7):1149-1157. https://doi.org/10.1007/s00276-021-02678-w
  37. Kim KA, Choi SY, Kim R. Endovascular Treatment for Lower Extremity Deep Vein Thrombosis: An Overview. Korean J Radiol. 2021;22(6):931.  https://doi.org/10.3348/kjr.2020.0675
  38. Kuperin AS, Khachatryan AS, An ES, Seliverstov EI, Lebedev IS. Endovascular Treatment in Patients with Deep Venous Thrombosis. Flebologiia. 2023;17(2):101.  https://doi.org/10.17116/flebo202317021101
  39. Lebedev IS, Maslennikov MA, Leontyev SG, Kim TG, Kirienko AI. Pharmacomechanical Recanalization of the Major Veins in Phlegmasia Cerulea Dolens Caused by Embolic Occlusion of Cava Filter. Flebologiia. 2020;14(1):40.  https://doi.org/10.17116/flebo20201401140
  40. Enden T, Haig Y, Kløw NE, Slagsvold CE, Sandvik L, Ghanima W, Hafsahl G, Holme PA, Holmen LO, Njaastad AM, Sandbæk G, Sandset PM; CaVenT Study Group. Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial. The Lancet. 2012;379(9810):31-38.  https://doi.org/10.1016/S0140-6736(11)61753-4
  41. Okada T, Yoshimoto T, Wada S, Yoshimura S, Chiba T, Egashira S, Kimura S, Shiozawa M, Inoue M, Ihara M, Toyoda K, Takashima H, Koga M. Intravenous Thrombolysis With Alteplase at 0.6 mg/kg in Patients With Ischemic Stroke Taking Direct Oral Anticoagulants. J Am Heart Assoc. 2022; 11(19):e025809. https://doi.org/10.1161/JAHA.122.025809
  42. Zhang X, Ren Q, Jiang X, Sun J, Gong J, Tang B, Chen Y. A Prospective Randomized Trial of Catheter-Directed Thrombolysis With Additional Balloon Dilatation for Iliofemoral Deep Venous Thrombosis: A Single-Center Experience. Cardiovasc Intervent Radiol. 2014;37(4):958-968.  https://doi.org/10.1007/s00270-013-0747-3
  43. Delis KT, Bjarnason H, Wennberg PW, Rooke TW, Gloviczki P. Successful Iliac Vein and Inferior Vena Cava Stenting Ameliorates Venous Claudication and Improves Venous Outflow, Calf Muscle Pump Function, and Clinical Status in Post-Thrombotic Syndrome. Ann Surg. 2007;245(1):130-139.  https://doi.org/10.1097/01.sla.0000245550.36159.93
  44. Sermsathanasawadi N, Pruekprasert K, Pitaksantayothin W, Chinsakchai K, Wongwanit C, Ruangsetakit C, Mutirangura P. Prevalence, risk factors, and evaluation of iliocaval obstruction in advanced chronic venous insufficiency. J Vasc Surg Venous Lymphat Disord. 2019;7(3):441-447.  https://doi.org/10.1016/j.jvsv.2018.10.021
  45. Taha MAH, Busuttil A, Bootun R, Thabet BAH, Badawy AEH, Hassan HA, Shalhoub J, Davies AH. A clinical guide to deep venous stenting for chronic iliofemoral venous obstruction. J Vasc Surg Venous Lymphat Disord. 2022; 10(1):258-266.  https://doi.org/10.1016/j.jvsv.2020.12.087
  46. Williams ZF, Dillavou ED. A systematic review of venous stents for iliac and venacaval occlusive disease. J Vasc Surg Venous Lymphat Disord. 2020;8(1):145-153.  https://doi.org/10.1016/j.jvsv.2019.08.015
  47. Raju S, Neglen P. High prevalence of nonthrombotic iliac vein lesions in chronic venous disease: A permissive role in pathogenicity. J Vasc Surg. 2006;44(1):136-144.  https://doi.org/10.1016/j.jvs.2006.02.065
  48. Neglén P, Raju S. Proximal lower extremity chronic venous outflow obstruction: Recognition and treatment. Semin Vasc Surg. 2002;15(1):57-64.  https://doi.org/10.1016/S0895-7967(02)70017-3
  49. Shamimi-Noori SM, Clark TWI. Venous Stents: Current Status and Future Directions. Tech Vasc Interv Radiol. 2018;21(2):113-116.  https://doi.org/10.1053/j.tvir.2018.03.007
  50. Litvinov AA. Comparative characteristics of venous stents. Bulletin of Pirogov National Medical & Surgical Center. 2021;16(2):98-104.  https://doi.org/10.25881/20728255_2021_16_2_98
  51. Rossi FH, Kambara AM, Izukawa NM, Rodrigues TO, Rossi CB, Sousa AG, Metzger PB, Thorpe PE. Randomized double-blinded study comparing medical treatment versus iliac vein stenting in chronic venous disease. J Vasc Surg Venous Lymphat Disord. 2018;6(2):183-191.  https://doi.org/10.1016/j.jvsv.2017.11.003
  52. Dake MD, O’Sullivan G, Shammas NW, Lichtenberg M, Mwipatayi BP, Settlage RA. Three-Year Results from the Venovo Venous Stent Study for the Treatment of Iliac and Femoral Vein Obstruction. Cardiovasc Intervent Radiol. 2021;44(12):1918-1929. https://doi.org/10.1007/s00270-021-02975-2
  53. Murphy E, Gibson K, Sapoval M, Dexter DJ, Kolluri R, Razavi M, Black S. Pivotal Study Evaluating the Safety and Effectiveness of the Abre Venous Self-Expanding Stent System in Patients With Symptomatic Iliofemoral Venous Outflow Obstruction. Circ Cardiovasc Interv. 2022;15(2):e010960. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010960
  54. Razavi C, Khalsa B, Openshaw L, Razavi MK. Single-Session Treatment of Patients with Symptomatic Iliocaval and Iliofemoral Deep Vein Thrombosis: Technical Results of a Prospective Pilot Study. Journal of Vascular and Interventional Radiology. 2022;33(2):183-188.  https://doi.org/10.1016/j.jvir.2021.10.011
  55. De Wolf MAF, de Graaf R, Kurstjens RLM, Penninx S, Jalaie H, Wittens CHA. Short-Term Clinical Experience with a Dedicated Venous Nitinol Stent: Initial Results with the Sinus-Venous Stent. European Journal of Vascular and Endovascular Surgery. 2015;50(4):518-526.  https://doi.org/10.1016/j.ejvs.2015.05.011
  56. Gavrilov SG, Lebedev IS, Vasiliev AV, Mishakina NYu. Medical and Economic Rationale of Venous Stenting for Chronic Obstruction. Flebologiia. 2023;17(2):92.  https://doi.org/10.17116/flebo20231702192
  57. Kang JM, Park KH, Ahn S, Cho S, Han A, Lee T, Jung IM, Kim JY, Min SK. Rivaroxaban after Thrombolysis in Acute Iliofemoral Venous Thrombosis: A Randomized, Open-labeled, Multicenter Trial. Sci Rep. 2019;9(1):20356. https://doi.org/10.1038/s41598-019-56887-w
  58. Crowner J, Marston W, Almeida J, McLafferty R, Passman M. Classification of anatomic involvement of the iliocaval venous outflow tract and its relationship to outcomes after iliocaval venous stenting. J Vasc Surg Venous Lymphat Disord. 2014;2(3):241-245.  https://doi.org/10.1016/j.jvsv.2014.02.002
  59. Endo M, Jahangiri Y, Horikawa M, Kaufman JA, Schenning RC, Kolbeck KJ, Barton RE, Ohuchi Y, Liang KW, Farsad K. Antiplatelet Therapy is Associated with Stent Patency After Iliocaval Venous Stenting. Cardiovasc Intervent Radiol. 2018;41(11):1691-1698. https://doi.org/10.1007/s00270-018-2062-5
  60. Lin C, Martin KA, Wang M, Stein BL, Desai KR. Long-term antithrombotic therapy after venous stent placement. Phlebology: The Journal of Venous Disease. 2020;35(6):402-408.  https://doi.org/10.1177/0268355519893819
  61. Milinis K, Thapar A, Shalhoub J, Davies AH. Antithrombotic Therapy Following Venous Stenting: International Delphi Consensus. European Journal of Vascular and Endovascular Surgery. 2018;55(4):537-544.  https://doi.org/10.1016/j.ejvs.2018.01.007

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