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Shadrina A.S.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Molecular Mechanisms Underlying the Development of Varicose Veins of Low Extremities

Authors:

Shadrina A.S., Zolotukhin I.A., Filipenko M.L.

More about the authors

Journal: Journal of Venous Disorders. 2017;11(2): 71‑75

DOI: 10.17116/flebo201711271-75

Read: 2836 times

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Table of contents

MOLECULAR MECHANISMS UNDERLYING THE DEVELOPMENT OF VARICOSE VEINS OF LOW EXTREMITIES
MOLECULAR MECHANISMS UNDERLYING THE DEVELOPMENT OF VARICOSE VEINS OF LOW EXTREMITIES

To cite this article:

Shadrina AS, Zolotukhin IA, Filipenko ML. Molecular Mechanisms Underlying the Development of Varicose Veins of Low Extremities. Journal of Venous Disorders. 2017;11(2):71‑75. (In Russ.)
https://doi.org/10.17116/flebo201711271-75

 
Подписка 2026 Флебология (Journal of Venous Disorders)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Varicose veins of lower extremities are a common human pathology. Its pathogenesis is still not fully investigated. Valvular incompetence and reflux have previously been thought to be the cause of this condition. However, recent evidence from ultrasound and histological studies indicates that structural and functional alterations in the vein wall can precede valvular dysfunction. These changes, on the one hand, are caused by changes in hemodynamic forces. On the other hand, they provoke further blood flow deceleration, blood stasis and vein wall stretch resulting in vicious cycle that is considered to underlie the development of varicose veins. The present review summarizes current knowledge about molecular mechanisms of varicose transformation.

Keywords:

varicose veins
pathogenesis
molecular mechanisms

Authors:

Shadrina A.S.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

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References:

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