Molecular Mechanisms Underlying the Development of Varicose Veins of Low Extremities

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Shadrina A.S.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Molecular Mechanisms Underlying the Development of Varicose Veins of Low Extremities

Authors:

Shadrina A.S., Zolotukhin I.A., Filipenko M.L.

More about the authors

Journal: Journal of Venous Disorders. 2017;11(2): 71‑75

DOI: 10.17116/flebo201711271-75

Views: 2088

Downloaded: 72

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Shadrina AS, Zolotukhin IA, Filipenko ML. Molecular Mechanisms Underlying the Development of Varicose Veins of Low Extremities. Journal of Venous Disorders. 2017;11(2):71‑75. (In Russ.)
https://doi.org/10.17116/flebo201711271-75

Подписка 2025 (Journal of Venous Disorders)

Close metadata

Varicose veins of lower extremities are a common human pathology. Its pathogenesis is still not fully investigated. Valvular incompetence and reflux have previously been thought to be the cause of this condition. However, recent evidence from ultrasound and histological studies indicates that structural and functional alterations in the vein wall can precede valvular dysfunction. These changes, on the one hand, are caused by changes in hemodynamic forces. On the other hand, they provoke further blood flow deceleration, blood stasis and vein wall stretch resulting in vicious cycle that is considered to underlie the development of varicose veins. The present review summarizes current knowledge about molecular mechanisms of varicose transformation.

Keywords:

varicose veins

pathogenesis

molecular mechanisms

Authors:

Shadrina A.S.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

List of references:

Cherkashin MA, Andriyashkin AV. Varicose veins of lower extremities. General issues of diagnostics and treatment. Russian medical journal. 2008;16(14):968-971. (In Russ.).
Badier-Commander C, Couvelard A, Henin D, Verbeuren T, Michel J-B, Jacob M-P. Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study. The Journal of Pathology. 2001;193(3):398-407. https://doi.org/10.1002/path.819
Aunapuu M, Arend A. Histopathological changes and expression of adhesion molecules and laminin in varicose veins. Vasa. 2005;34(3):170-175. https://doi.org/10.1024/0301-1526.34.3.170
Surendran S, Ramegowda K, Suresh A, Binil Raj SS, Lakkappa RKB, Kamalapurkar G, Radhakrishnan N, Kartha CС. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Laboratory Investigation. 2016;96(4):399-408. https://doi.org/10.1038/labinvest.2015.167
Naoum JJ, Hunter GC, Woodside KJ, Chen C. Current Advances in the Pathogenesis of Varicose Veins. Journal of Surgical Research. 2007;141(2):311-316. https://doi.org/10.1016/j.jss.2006.08.007
Ghaderian SMH, Khodaii Z. Tissue remodeling investigation in varicose veins. International Journal of Molecular and Cellular Medicine. 2012;1(1):50-61.
Segiet OA, Brzozowa M, Piecuch A, Dudek D, Reichman-Warmusz E, Wojnicz R. Biomolecular mechanisms in varicose veins development. Annals of Vascular Surgery. 2015;29(2):377-384. https://doi.org/10.1016/j.avsg.2014.10.009
Tsukanov Yu.T., Tsukanov A.Yu., Shcheglov A.Yu., Mozgovoi S.I. Patomorfologicheskie aspekty varikoznogo porazheniya ven nizhnei poloviny tulovishcha. Vestnik Sankt-Peterburgskogo universiteta. 2006;11(3):50-61.
Woodside KJ, Hu M, Burke A, Murakami M, Pounds LL, Killewich LA, Daller JA, Hunter GC. Morphologic characteristics of varicose veins: possible role of metalloproteinases. Journal of Vascular Surgery. 2003;38(1):162-169. https://doi.org/10.1016/S0741-5214(03)00134-4
Lim CS, Davies AH. Pathogenesis of primary varicose veins. The British Journal of Surgery. 2009;96(11):1231-1242. https://doi.org/10.1002/bjs.6798
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M. Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovascular Research. 2016;110(3):419-430. https://doi.org/10.1093/cvr/cvw075
Pfisterer L, König G, Hecker M, Korff T. Pathogenesis of varicose veins — lessons from biomechanics. Vasa. 2014;43(2):88-99. https://doi.org/10.1024/0301-1526/a000335
Krysa J, Jones GT, van Rij AM. Evidence for a genetic role in varicose veins and chronic venous insufficiency. Phlebology. 2012;27(7):329-335. https://doi.org/10.1258/phleb.2011.011030
Anwar MA, Shalhoub J, Lim CS, Gohel MS, Davies AH. The effect of pressure-induced mechanical stretch on vascular wall differential gene expression. Journal of Vascular Research. 2012;49(6):463-478. https://doi.org/10.1159/000339151
Lim CS, Kiriakidis S, Sandison A, Paleolog EM, Davies AH. Hypoxia-inducible factor pathway and diseases of the vascular wall. Journal of Vascular Surgery. 2013;58(1):219-230. https://doi.org/10.1016/j.jvs.2013.02.240
Lim CS, Shalhoub J, Gohel MS, Shepherd AC, Davies AH. Matrix metalloproteinases in vascular disease — a potential therapeutic target? Current Vascular Pharmacology. 2010;8(1):75-85. https://doi.org/10.2174/157016110790226697
Lattimer CR, Kalodiki E, Geroulakos G, Hoppensteadt D, Fareed J. Are Inflammatory Biomarkers Increased in Varicose Vein Blood? Clinical and Applied Thrombosis/Hemostasis. 2016;22(7):656-664. https://doi.org/10.1177/1076029616645330
del Rio Solá L, Aceves M, Dueñas AI, González-Fajardo JA, Vaquero C, Crespo MS, García-Rodríguez C. Varicose veins show enhanced chemokine expression. European Journal of Vascular and Endovascular Surgery. 2009;38(5):635-641. https://doi.org/10.1016/j.ejvs.2009.07.021
Yasim A, Kilinc M, Aral M, Oksuz H, Kabalci M, Eroglu E, Imrek S. Serum concentration of procoagulant, endothelial and oxidative stress markers in early primary varicose veins. Phlebology. 2008;23(1):15-20. https://doi.org/10.1258/phleb.2007.007014
Viedt C, Vogel J, Athanasiou T, Shen W, Orth SR, Kübler W, Kreuzer J. Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1. Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22(6):914-920. https://doi.org/10.1161/01.ATV.0000019009.73586.7F
Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. The Journal of Biological Chemistry. 2001;276(10):7614-7620. https://doi.org/10.1074/jbc.M009705200
Shoab S, Scurr J, Coleridge-Smith P. Increased plasma vascular endothelial growth factor among patients with chronic venous disease. Journal of Vascular Surgery. 1998;28(3):535-540. https://doi.org/10.1016/S0741-5214(98)70141-7
Howlader MH, Coleridge Smith PD. Relationship of plasma vascular endothelial growth factor to CEAP clinical stage and symptoms in patients with chronic venous disease. European Journal of Vascular and Endovascular Surgery. 2004;27(1):89-93. https://doi.org/10.1016/j.ejvs.2003.10.002
Esser S, Wolburg K, Wolburg H, Breier G, Kurzchalia T, Risau W. Vascular endothelial growth factor induces endothelial fenestrations in vitro. The Journal of Cell Biology. 1998;140(4):947-959.
Kowalewski R, Małkowski A, Sobolewski K, Gacko M. Vascular endothelial growth factor and its receptors in the varicose vein wall. Acta Angiologica. 2011;17(2):141-149.
Guzik B, Chwała M, Matusik P, Ludew D, Skiba D, Wilk G, Mrowiecki W, Batko B, Cencora A, Kapelak B, Sadowski J, Korbut R, Guzik TJ. Mechanisms of increased vascular superoxide production in human varicose veins. Polskie Archiwum Medycyny Wewnętrznej. 2011;121(9):279-286.
Surendran S, Girijamma A, Nair R, Ramegowda KS, Nair DH, Thulaseedharan JV, Lakkappa RB, Kamalapurkar G, Kartha CC. Forkhead box C2 promoter variant c.-512C>T is associated with increased susceptibility to chronic venous diseases. PLoS One. 2014;9(3):e90682. https://doi.org/10.1371/journal.pone.0090682

Close metadata

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.