Objective. To evaluate the safety and effectiveness of endovasal laser ablation (EVLA) performed in different energy regimes in the combination with echosclerotherapy for the treatment of the patients presenting with primary varicose veins. Material and methods. In the first group of patients (n=355), EVLA was performed using laser radiation with a wavelength of 1060 nm and in the second group (n=360) with a wavelength of 1470 and 1560 nm taking no account of the diameter of the saphenous vein trunks. The patients of the third group (n=343) were treated with the use of EVLA at a wavelength of 1470 and 1560 nm taking into consideration the diameter of the saphenous vein trunks. Results. The control ultrasound study carried out within a period from 2 to 6 months after surgery revealed recanalization of the trunk of the femoral great saphenous vein (GSV) of different extension in 10 (3%) and 5 (1.4%) patients of groups 1 and 2 respectively. In 343 (100%) patients of the third group obliteration of the GSV trunk was achieved without an additional intervention. The repeated intervention resulted in the obliteration of the great saphenous vein trunk in all the patients of the remaining two groups. Clinical observations have demonstrated reduced swelling in the patients of all three groups presenting with C3—C6 varicose veins. Moreover, they experienced a decrease of the medial malleolus circumference within 6 months after the treatment. In the patients of all the three groups with C4 varicose veins and signs of venous eczema they were eliminated as a result of the treatment. Conclusion. The application of energy regimes of laser irradiation on an individual basis depending on the diameter of the saphenous vein trunks in the combination with echosclerotherapy of their subcutaneous tributaries made it possible to avoid recanalization of the GSV trunk following endovasal laser ablation in the patients of group 3 with the simultaneous reduction of linear energy density.