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Kamaev A.A.

Pavlov Ryazan State Medical University

Kalinin R.E.

Pavlov Ryazan State Medical University

Mzhavanadze N.D.

Pavlov Ryazan State Medical University

Povarov V.O.

Pavlov Ryazan State Medical University

Yanykina K.V.

Pavlov Ryazan State Medical University

Suchkov I.A.

Pavlov Ryazan State Medical University

Effect of Sulodexide on Endothelial Function and Quality of Life in Patients with Varicose Veins

Authors:

Kamaev A.A., Kalinin R.E., Mzhavanadze N.D., Povarov V.O., Yanykina K.V., Suchkov I.A.

More about the authors

Journal: Journal of Venous Disorders. 2024;18(4): 308‑316

DOI: 10.17116/flebo202418041308

Read: 1579 times

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Table of contents

EFFECT OF SULODEXIDE ON ENDOTHELIAL FUNCTION AND QUALITY OF LIFE IN PATIENTS WITH VARICOSE VEINS
EFFECT OF SULODEXIDE ON ENDOTHELIAL FUNCTION AND QUALITY OF LIFE IN PATIENTS WITH VARICOSE VEINS

To cite this article:

Kamaev AA, Kalinin RE, Mzhavanadze ND, Povarov VO, Yanykina KV, Suchkov IA. Effect of Sulodexide on Endothelial Function and Quality of Life in Patients with Varicose Veins. Journal of Venous Disorders. 2024;18(4):308‑316. (In Russ.)
https://doi.org/10.17116/flebo202418041308

Подписка 2026 Флебология (Journal of Venous Disorders)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE. T

O study the effect of sulodexide on endothelial dysfunction and quality of life in patients with varicose veins.

MATERIAL AND METHODS

The study included 93 patients with varicose veins CEAP class C2-C3. They were divided into 4 groups: group 1 — compression hosiery; group 2 — sulodexide 250 LE 2 times a day; group 3 — endovenous laser ablation; group 4 — endovenous laser ablation followed by sulodexide therapy. We analyzed serum E-selectin, MCP-1, VEGF, MMP-2 and MMP-9 as markers of endothelial dysfunction and vein-specific inflammation. Quality of life changes were assessed using the CIVIQ-20 and SF-36 questionnaires.

RESULTS

E-selectin decreased by 24% after 2 months in the 1st group (p=0.004). In the 2nd group, E-selectin, MCP-1, MMP-2 and MMP-9 significantly decreased (p=0.001, p<0.001, p<0.001 and p=0.04, respectively), while VEGF did not change (p=0.73). E-selectin, MCP-1 and MMP-9 decreased in the 3rd group. In the 4th group, all indicators decreased after complex treatment. After 2-month therapy, QoL improved in all groups (p<0.05), except for the first group (CIVIQ-20 questionnaire, p=0.73).

CONCLUSION

Sulodexide therapy, especially after invasive treatment, improves the quality of life, reduces serum markers of endothelial dysfunction and vein-specific inflammation.

Keywords:

vein-specific inflammation
sulodexide
endovenous laser ablation
quality of life
varicose veins of the lower extremities

Authors:

Kamaev A.A.

Pavlov Ryazan State Medical University

Kalinin R.E.

Pavlov Ryazan State Medical University

Mzhavanadze N.D.

Pavlov Ryazan State Medical University

Povarov V.O.

Pavlov Ryazan State Medical University

Yanykina K.V.

Pavlov Ryazan State Medical University

Suchkov I.A.

Pavlov Ryazan State Medical University

Received:

12.09.2024

Accepted:

20.10.2024

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