A total of 59 hospitals from all regions of the Russian Federation were involved in the second phase of the Venous thromboembolic complication safety zone Project. The data on 59,443 patients were collected including 36,785 surgically managed patients and 22,658 therapeutically managed ones (61.9% and 38.1% respectively). The risk of venous thromboembolic complications (VTEC) was estimated in all the patients. 14,162 (38.5%) surgical patients were referred to the low risk group. 11,412 (31.0%) and 11,211 (30.5%) ones to the moderate and high risk groups respectively. 6,657 (29.4%) and 16,001 (70.6%) therapeutically managed patients were included in the low and high VTEC risk groups. Expert verification of the patient distribution by the risk groups showed that they were adequately allocated by surgeons and therapists in 68.6% and 89.6% of the cases respectively. The surgeons underestimated the threat of VTEC in 22.7% of the patients and overestimated it in 8.7% of the patients. Specialists of non-surgical settings underestimated the risk of VTEC in 4.5% of the cases and overestimated it in 5.9% of the patients. Preventive measures against VTEC were prescribed to the majority of the patients included in the study. Early activation measures were recommended in the postoperative period to 85.8% of the patients in the surgical departments, elastic compression of the lower extremities to 75.1%, and preventive medicamental treatment to 65.0%. The latter modality was prescribed to 66.6% and elastic compression of the lower extremities to 40,0% of the patients staying in therapeutic wards. Practically all the patients at high risk of VTEC were given anticoagulants (98.7% and 88.6% of those admitted to surgical and therapeutic wards respectively). General lethality was 2.14%. Pulmonary thromboembolism was the cause of death in 0.046% and 0.2% of the surgically and therapeutically managed patients respectively. It is concluded that the above intermediate results give evidence of success of the second phase of the Venous thromboembolic complication safety zone Project.