There is a wealth of data concerning the effectiveness of the use of cellular technologies for the stimulation of angiogenesis. Aim of the study. To assess the possibility of paravasal application of autologous multipotent mesenchymal stem cells originating from bone marrow (BMAMSC) for the restoration of circulation in a thrombosed vein under experimental conditions. Material and methods. Luminescence microscopy was used to evaluate the results of administration of mesenchymal stem cells originating from bone marrow with the GFP gene and additionally DAPI stained cell nuclei close to the thrombosed vein in a hind leg of rats. Results. It was shown that BMAMSC take part in the development of granulations at the site of surgical intervention performed to simulate thrombosis. Restoration of blood circulation in the major thrombosed vein always occurs through thrombolysis. There are no signs suggesting the BMAMSC are built in the thrombosed vessel. Neither recanalization of the thrombus nor formation of collateral vessels was documented. Experimental simulation of thrombosis by means of thrombin administration and ligation of the major vein resulted in the formation of blood clots in its small branches. Conclusion. It was shown that the administration of BMAMSC promotes the earlier and fast granulation at the site of surgical intervention performed to simulate thrombosis. Moreover, it accelerates wound cleansing from detritus, non-viable tissues, and antigenic substances. BMAMSC stimulate the early development of reparation processes and wound healing at the site of intervention. BMAMSC contribute to the restoration of blood flow in the branches of the thrombosed vein, recanalization of the blood clot, and growth of new vessels replacing the obliterated ones. In the course of time, the administered BMAMSC and the structures that form with their participation are replaced by the cells of the recipient organism.