Sclerosing agents: efficiency, adverse reactions, complications

Close metadata

Recommended articles:

Molecular Genetic Aspects of Varicose Vein Disease: Modern Concepts. Journal of Venous Disorders. 2024;(1):48-53

Mechanochemical Ablation in the Treatment of Varicose Veins. Journal of Venous Disorders. 2024;(1):72-76

Complications and gestational outcomes in women with new SARS-CoV-2 coronavirus infection during pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2023;(6-2):167-172

Late complications after injectable lips contour correction simulating an amelanotic melanoma. Russian Journal of Clinical Dermatology and Venereology. 2023;(6):749-756

Neurological complications after covid-19 vaccination. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(12):13-19

Improving surgical technique for tracheal resection with anastomosis. Pirogov Russian Journal of Surgery. 2024;(1):6-20

Endobronchial hamartoma. P.A. Herzen Journal of Oncology. 2024;(1):59-62

Creatine phosphokinase in predicting clinical outcomes in patients with acute limb ischemia. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(1):89-93

Case emergency applying tracheostomy in case of hematoma of the bottom of the oral cavity resulting from the operation of tooth extraction of the third molar of the lower jaw. Russian Journal of Stomatology. 2024;(1):15-17

Short-term outcomes of mechanical and hand-sewn laparoscopic one-anastomosis mini-gastric bypass. Pirogov Russian Journal of Surgery. 2024;(4):29-37

This literature review concerns the efficiency and spectrum of adverse reactions during therapy with various sclerosing preparations. Results of clinical and experimental investigations are presented to demonstrate the mechanisms of action of modern sclerosing agents and their influence on the blood coagulation system. The relationship between the intensity of therapeutic intervention, frequency and spectrum of adverse events and complications is discussed. The authors conclude that the most commonly used sclerosing medicines (polydocanol and sodium tetradecyl sulfate) are virtually identical as far as their principal characteristics being compared are concerned.

Keywords:

sclerotheraty

primary varicosis

sclerosing agents

adverse events

complications

Authors:

Ivanov E.V.

Lomonosov Moscow State University, Moscow, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

List of references:

Bergan J. The Vein Book. Elsevier Academic Press 2007;617.
Savel'ev V.S. Flebologiya : Rukovodstvo dlya vrachei. Pod red. V.S. Savel'eva. M: Meditsina 2001;664.
Rabe E., Wollmann J.-C. Brief history of sclerotherapy. In: Sclero Guide. Bonn: Rabe Medical Publishing 2009;9-23.
Knunyants I.L. Khimicheskii entsiklopedicheskii slovar'. M: Sovetskaya entsiklopediya 1983;792.
Loktev S.M., Klimenko V.L., Kamzolkin V.V. i dr. Vysshie zhirnye spirty (oblasti primeneniya, metody proizvodstva, fiziko-khimicheskie svoistva). M: Izd-vo Khimiya 1970;328.
Goldman M.P., Kaplan R.P., Oki L.N. et al. Sclerosing agents in the treatment of telangiectasia. Comparison of the clinical and histologic effects of intravascular polidocanol, sodium tetradecyl sulfate, and hypertonic saline in the dorsal rabbit ear vein model. Arch Dermatol 1987;123:9:1196-1201.
Martin D.E., Goldman M.P. A comparison of sclerosing agents: clinical and histologic effects of intravascular sodium tetradecyl sulfate and chromated glycerin in the dorsal rabbit ear vein. J Dermatol Surg Oncol 1990;16:1:18-22.
Rotter S.M., Weiss R.A. Human saphenous vein in vitro model for studying the action of sclerosing solutions. J Dermatol Surg Oncol 1993;19:1:59-62.
Kobayashi S., Crooks S., Eckmann D.M. Dose- and Time-Dependent Liquid Sclerosant Effects on Endothelial Cell Death. Dermatol Surg 2006;32:1444-1452.
Myers K.A., Wood S.R., Lee V. Early results for objective follow-up by duplex ultrasound scanning after echosclerotherapy or surgery for varicose veins. Aust NZJ Phleb 2000;4:71-74.
Barrett J.M., Allen B., Ockelford A., Goldman M.P. Microfoam Ultrasound-Guided Sclerotherapy of Varicose Veins in 100 Legs. Dermatol Surg 2004;30:6-12.
Guex J.J., Allaert F.A., Gillet J.L., Chleir F. Immediate and midterm complications of sclerotherapy: report of a prospective multicenter registry of 12,173 sclerotherapy sessions. Dermatol Surg 2005;31:123-128.
Bihari I. Injection sclerotherapy for varicosities of the lower limb: 25 years of experience with 115000 injections. Orv Hetil 2007;148:2:51-58.
Parsi K., Exner T., Connor D.E. et al. In vitro effects of detergent sclerosants on coagulation, platelets and microparticles. Eur J Vasc Endovasc Surg 2007;34:6:731-740.
Parsi K., Exner T., Connor D.E. et al. The lytic effects of detergent sclerosants on erythrocytes, platelets, endothelial cells and microparticles are attenuated by albumin and other plasma components in vitro. Eur J Vasc Endovasc Surg 2008;36:2:216-223.
Parsi K., Exner T., Low J. et al. In vitro effects of detergent sclerosants on antithrombotic mechanisms. Eur J Vasc Endovasc Surg 2009;38:2:220-228.
Parsi K. Interaction of detergent sclerosants with the thrombohaemostatic system. Intern Angiol 2009;28:Suppl 1:4:152-153.
Bhargava D.K., Singh B., Dogra R. et al. Prospective randomized comparison of sodium tetradecyl sulfate and polidocanol as variceal sclerosing agents. Am J Gastroenterol 1992;87:2:182-186.
Ravi M., Kate V., Ananthakrishnan N. Prospective randomized comparison of sodium tetradecyl sulphate & polidocanol for oesophageal variceal sclerotherapy. Indian J Med Res 2001;113:228-233.
Jutabha R., Jensen D.M., See J. et al. Randomized, controlled study of various agents for endoscopic injection sclerotherapy of bleeding canine gastric varices. Gastrointest Endosc 1995;41:3:206-211.
Labas P., Smolen V. Sclerosing agents in clinical practice. Cas Lek Cesk 1996;135:24:796-798.
Goldman M.P. Treatment of varicose and telangiectatic leg veins: double-blind prospective comparative trial between aethoxyskerol and sotradecol. Dermatol Surg 2002;28:1:52-55.
Rao J., Wildemore J.K., Goldman M.P. Double-Blind Prospective Comparative Trial between Foamed and Liquid Polidocanol and Sodium Tetradecyl Sulfate in the Treatment of Varicose and Telangiectatic Leg Veins. Dermatol Surg 2005;31:631-635.
Stricker B.H., van Oijen J.A., Kroon C., Ovink A.H. Anaphylaxis following use of polidocanol. Ned Tijdschr Geneeskd 1990;134:5:240-242.
Feied C.F., Jackson J.J., Bren T.S. et al. Allergic reactions to polidocanol for vein sclerosis. Two case reports. J Dermatol Surg Oncol 1994;20:7:466-468.
Reichelt A., Narvaes L., Ferreira J., Goldani M.A. Severe drug-induced skin reaction after sclerotherapy. Intern Angiol 2009;28:Suppl 1:4:139.
Geukens J., Rabe E., Bieber T. Embolia cutis medicamentosa of the foot after sclerotherapy. Eur J Dermatol 1999;9:2:132-133.
Boespflug O. Anaphylactic shock following an injection of trombovar. Phlebologie 1974;27:2:191-193.
Fronek H., Fronek A., Saltzberg G. Allergic reactions to Sotradecol. J Dermatol Surg Oncol 1989;15:6:684.
Brzoza Z., Kasperska-Zajac A., Rogala E., Rogala B. Anaphylactoid reaction after the use of sodium tetradecyl sulfate: a case report. Angiology 2007;58:5:644-646.

Close metadata