The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sukhotskaya A.A.

Almazov National Medical Research Centre

Bairov V.G.

Almazov National Medical Research Centre

Kagantsov I.M.

Almazov National Medical Research Centre

Nikitina I.L.

Almazov National Medical Research Centre

Mitrofanova L.B.

Almazov National Medical Research Centre

Perminova A.A.

Almazov National Medical Research Centre

Ryzhkova D.V.

Almazov National Medical Research Centre

Malysheva D.A.

Almazov National Medical Research Centre

Open and laparoscopic resections of the pancreas in congenital hyperinsulinism

Authors:

Sukhotskaya A.A., Bairov V.G., Kagantsov I.M., Nikitina I.L., Mitrofanova L.B., Perminova A.A., Ryzhkova D.V., Malysheva D.A.

More about the authors

Journal: Endoscopic Surgery. 2023;29(5): 15‑22

DOI: 10.17116/endoskop20232905115

Views: 975

Downloaded: 26

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Sukhotskaya AA, Bairov VG, Kagantsov IM, et al. . Open and laparoscopic resections of the pancreas in congenital hyperinsulinism. Endoscopic Surgery. 2023;29(5):15‑22. (In Russ.)
https://doi.org/10.17116/endoskop20232905115

Подписка 2025 (Endoscopic Surgery)
МСФ на ЯМ
Close metadata
Recommended articles:
Possibilities of lapa­roscopy in the treatment of patients with retroperitoneal lipo­sarcoma. Endo­scopic Surgery. 2023;(6):71-75
Robot-assisted cholecystectomy in children. Endo­scopic Surgery. 2023;(6):82-88
Proximal ureterouretheroanastomosis in the treatment of kidney double in children. Endo­scopic Surgery. 2023;(6):103-110
Histological evaluation of esophageal stri­cture in children with caustic burn. Piro­gov Russian Journal of Surgery. 2023;(12):43-51
Consequences of the COVID-19 pandemic for surgical service. Piro­gov Russian Journal of Surgery. 2023;(12):103-109
Reco­nstruction of total portosystemic shunt into sele­ctive portosystemic shunt in a child. Piro­gov Russian Journal of Surgery. 2023;(12):140-146
Prognostic value of outpatient endo­scopy for the diagnosis of eosi­nophilic esophagitis in children. Russian Journal of Evidence-Based Gastroenterology. 2023;(4):5-10
Gastritis and gastroesophageal reflux disease in schoolchildren from ethnic groups in the Repu­blic of Tuva. Russian Journal of Evidence-Based Gastroenterology. 2023;(4):36-42
Evaluation of the possibility of diagnosing puru­lent-septic rhinogenic complications of the orbit and eyelids in children based on the analysis of clinical and labo­ratory data. Russian Bulletin of Otorhinolaryngology. 2023;(6):56-60
Thoracoscopic tracheal rese­ction in a child under extracorporeal membrane oxygenation. Piro­gov Russian Journal of Surgery. 2024;(1):86-90

INTRODUCTION

Congenital hyperinsulinism (CHI) is characterized by recurrent episodes of hyperisulinemic hypoglycemias because of various genetic disorders. Diffuse drug-unresponsive and focal forms of CHI can be surgically treated. Nowadays there are only a few articles about maloinvasive selective resection of pancreas or pancreatectomy in children.

MATERIAL AND METHODS

52 children were operated on for congenital hyperinsulinism in the department of pediatric surgery in the Almazov Medical Research Center from 2017 till April 2022, three of them were treated by laparoscopic approach.

RESULTS

According to results of PET/CT with 18F-DOPA in 52 children, diagnosed 12 (23.0%) diffuse forms, 33 (63.5%) focal and 7 (13.5%) atypical form. In this article authors describe 3 clinical cases of maloinvasive surgical treatment of focal CHI forms.

CONCLUSION

Our initial experience of using laparoscopic approach showed the possibility of its effective use in CHI. The results were similar with open pancreatic surgery both in achieving relief of hyperinsulinism in focal forms and in a differentiated approach to the volume of removal of the gland (enucleation or distal resection).

Keywords:

congenital hyperinsulinism
surgery
laparoscopy
pancreas resection
children

Authors:

Sukhotskaya A.A.

Almazov National Medical Research Centre

Bairov V.G.

Almazov National Medical Research Centre

Kagantsov I.M.

Almazov National Medical Research Centre

Nikitina I.L.

Almazov National Medical Research Centre

Mitrofanova L.B.

Almazov National Medical Research Centre

Perminova A.A.

Almazov National Medical Research Centre

Ryzhkova D.V.

Almazov National Medical Research Centre

Malysheva D.A.

Almazov National Medical Research Centre

Received:

01.08.2022

Accepted:

20.04.2023

List of references:

  1. McQuarrie I. Idiopathic spontaneously occurring hypoglycemia in infants; clinical significance of problem and treatment. Arch Pediatr Adolesc Med. 1954;87(4):399-428.  https://doi.org/10.1001/archpedi.1954.02050090387001
  2. Kapoor RR, Flanagan SE, Arya VB, Shield JP, Ellard S, Hussain K. Clinical and molecular characterisation of 300 patients with congenital hyperinsulinism. Eur J Endocrinol. 2013;168(4):557-564.  https://doi.org/10.1530/EJE-12-0673
  3. Menni F, de Lonlay P, Sevin C, Touati G, Peigné C, Barbier V, Nihoul-Fékété C, Saudubray JM, Robert JJ. Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia. Pediatrics. 2001;107:476-479.  https://doi.org/10.1542/peds.107.3.476
  4. Helleskov A, Melikyan M, Globa E, Shcherderkina I, Poertner F, Larsen AM, Filipsen K, Brusgaard K, Christiansen CD, Hansen LK, Christesen HT. Both Low Blood Glucose and Insufficient Treatment Confer Risk of Neurodevelopmental Impairment in Congenital Hyperinsulinism: A Multinational Cohort Study. Front Endocrinol (Lausanne). 2017;8:156.  https://doi.org/10.3389/fendo.2017.00156
  5. Melikjan MA, Kareva MA, Petrjaikina EE, Volkov IJe, Aver’janova JuV, Kolomina IG, Gurevich LE, Peterkova VA, Brusgaard K, Christesen HT, Dedov II. Vrozhdennyj giperinsulinizm. Rezul’taty molekuljarno-geneticheskih issledovanii v Rossiiskoi populjacii. Problemy endokrinologii. 2012;58(2):3-9. (In Russ.).
  6. Rahier J, Guiot Y, Sempoux C. Morphologic analysis of focal and diffuse forms of congenital hyperinsulinism. Semin Pediatr Surg. 2011;20(1):3-12.  https://doi.org/10.1053/j.sempedsurg.2010.10.010
  7. Sempoux Ch, Guiot Y, Jaubert F, Rahier J. Focal and diffuse forms of congenital hyperinsulinism: the keys for differential diagnosis. Endocrine Pathol. 2004;15(3):241-246.  https://doi.org/10.1385/ep:15:3:241
  8. Demirbilek H, Rahman SA, Buyukyilmaz GG, Hussain K. Diagnosis and treatment of hyperinsulinaemic hypoglycaemia and its implications for paediatric endocrinology. Int J Pediatr Endocrinol. 2017;30;9(suppl 2):69-87.  https://doi.org/10.4274/jcrpe.2017.S007
  9. Han B, Mohamed Z, Estebanez MS, Craigie RJ, Newbould M, Cheesman E, Padidela R, Skae M, Johnson M, Flanagan S, Ellard S, Cosgrove KE, Banerjee I, Dunne MJ. Atypical forms of congenital hyperinsulinism in infancy are associated with mosaic patterns of immature islet cells. J Clin Endocrinol Metab. 2017;102(9):3261-3267. https://doi.org/10.1210/jc.2017-00158
  10. Stanley CA, Thornton PS, Ganguly A, MacMullen C, Underwood P, Bhatia P, Steinkrauss L, Wanner L, Kaye R, Ruchelli E, Mariko Suchi M, Adzick NS. Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. J Clin Endocrinol Metab. 2004;89(1):288-296.  https://doi.org/10.1210/jc.2003-030965
  11. Adzick NS, De Leon DD, States LJ, Lord K, Bhatti TR, Becker SA, Stanley CA. Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children. J Pediatr Surg. 2019;54:27-32.  https://doi.org/10.1016/j.jpedsurg.2018.10.030
  12. Sukhotskaya AA, Bairov VG, Perminova AA, Mitrofanova LB, Nikitina IL, Ryzhkova DV, Amidhonova SA. Dependence of pancreas resection volume on PET-tomography and express biopsy findings. Detskaya khirurgiya. Zhurnal im. Ju.F. Isakova. 2021;25(1):11-18. (In Russ.). https://doi.org/10.18821/1560-9510-2021-25-1-11-18
  13. Hardy OT, Hernandez-Pampaloni M, Saffer JR, Scheuermann JS, Ernst LM, Freifelder R, Zhuang H, MacMullen C, Becker S, Adzick NS, Divgi C, Alavi A, Stanley CA. Accuracy of [18F] fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism. J Clin Endocrinol Metab. 2007;92(12):4706-4711. https://doi.org/10.1210/jc.2007-1637
  14. Mohnike K, Blankenstein O, Minn H, Mohnike W, Fuchtner F, Otonkoski T. 18F-DOPA positron emission tomography for preoperative localization in congenital hyperinsulinism. Horm Res. 2008;70(2):65-72.  https://doi.org/10.1159/000137655
  15. Ribeiro MJ, Boddaert N, Bellanné-Chantelot C, Bourgeois S, Valayannopoulos V, Delzescaux T, Jaubert F, Nihoul-Fékété C, Brunelle F, De Lonlay P. The added value of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy: a retrospective study involving 49 children. Eur J Nucl Med Mol Imag. 2007;34(12):2120-2128. https://doi.org/10.1007/s00259-007-0498-y
  16. Fékété CN, de Lonlay P, Jaubert F, Rahier J, Brunelle F, Saudubray JM: The surgical management of congenital hyperinsulinemic hypoglycemia in infancy. J Pediatr Surg. 2004;39(3):267-269.  https://doi.org/10.1016/j.jpedsurg.2003.11.004
  17. Adzick NS, Thornton PS, Stanley CA, Kaye RD, Ruchelli E. A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy. J Pediatr Surg. 2004;39(3):270-275.  https://doi.org/10.1016/j.jpedsurg.2003.11.019
  18. Blakely ML, Lobe TE, Cohen J, Burghen GA. Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy. Surg Endosc. 2001;15(8):897-878.  https://doi.org/10.1007/s004640040031
  19. Bax KN, van der Zee DC. The laparoscopic approach toward hyperinsulinism in children. Semin Pediatr Surg. 2007;16(4):245-251.  https://doi.org/10.1053/j.sempedsurg.2007.06.006
  20. Zhang JS, Li L, Cheng W. Single incision laparoscopic 90% pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. Pediatr Surg Int. 2016;32(10):1003-1007. https://doi.org/10.1007/s00383-016-3943-9
  21. Al-Shanafey S. Laparoscopic vs open pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy. J Pediatr Surg. 2009;44(5):957-961.  https://doi.org/10.1016/j.jpedsurg.2009.01.042
  22. Pierro A, Nah SA. Surgical management of congenital hyperinsulinism of infancy. Semin Pediatr Surg. 2011;20(1):50-53.  https://doi.org/10.1053/j.sempedsurg.2010.10.009
  23. Sokolov YuYu, Melikyan MA, Efremenkov AM, Gubaeva DN, Druzhinin VR, Osmanov IM. Laparoscopic resections of the pancreas in children with hyperinsulinism. Detskaya khirurgiya. Zhurnal im. Ju.F. Isakova. 2020;24(6):363-369. (In Russ.). https://doi.org/10.18821/1560-9510-2020-24-6-363-369
  24. Jaffray B. Minimally invasive surgery. Arch Dis Child. 2005;90(5):537-542.  https://doi.org/10.1136/adc.2004.062760
  25. Cawich SO, Kluger MD, Francis W, Deshpande RR, Mohammed F, Bonadie KO, Thomas DA, Pearce NW, Schrope BA. Review of minimally invasive pancreas surgery and opinion on its incorporation into low volume and resource poor centres. World J Gastrointest Surg. 2021;13(10):1122-1135. https://doi.org/10.4240/wjgs.v13.i10.1122
  26. Gagner M, Pomp A. Laparoscopic pylorus-preserving pancreatoduodenectomy. Surg Endosc. 1994;8(5):408-410.  https://doi.org/10.1007/bf00642443
  27. Cuschieri SA, Jakimowicz JJ. Laparoscopic pancreatic resections. Semin Laparosc Surg. 1998;5(3):168-179.  https://doi.org/10.1177/155335069800500303
  28. Sussman LA, Christie R, Whittle DE. Laparoscopic excision of distal pancreas including insulinoma. Aust N Z J Surg. 1996;66(6):414-416.  https://doi.org/10.1111/j.1445-2197.1996.tb01222.x
  29. Gagner M, Pomp A, Herrera MF. Early experience with laparoscopic resections of islet cell tumors. Surgery. 1996;120(6):1051-1054. https://doi.org/10.1016/s0039-6060(96)80054-7
  30. Tihanyi TF, Morvay K, Nehéz L, Winternitz T, Rusz Z, Flautner LE. Laparoscopic distal resection of the pancreas with the preservation of the spleen. Acta Chir Hung. 1997;36(1-4):359-361. 
  31. Vezakis A, Davides D, Larvin M, McMahon MJ. Laparoscopic surgery combined with preservation of the spleen for distal pancreatic tumors. Surg Endosc. 1999;13(1):26-29.  https://doi.org/10.1007/s004649900891
  32. Matsumoto T, Kitano S, Yoshida T, Bandoh T, Kakisako K, Ninomiya K, Tsuboi S, Baatar D. Laparoscopic resection of a pancreatic mucinous cystadenoma using laparosonic coagulating shears. Surg Endosc. 1999;13(2):172-173.  https://doi.org/10.1007/s004649900933
  33. Park A, Schwartz R, Tandan V, Anvari M. Laparoscopic pancreatic surgery. Am J Surg. 1999;177(2):158-163.  https://doi.org/10.1016/s0002-9610(98)00325-0
  34. Cuschieri SA, Jakimowicz JJ. Laparoscopic pancreatic resections. Semin Laparosc Surg. 1998;5(3):168-179.  https://doi.org/10.1177/155335069800500303
  35. Al-Shanafey S, Habib Z, AlNassar S. Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy. J Pediatr Surg. 2009;44(1):134-138; discussion 138.  https://doi.org/10.1016/j.jpedsurg.2008.10.120
  36. Soheilipour F, Jesmi F, Ahmadi M, Pazouki A, Alibeigi P, Abdolhosseini M. Minimally invasive surgical interventions in the treatment of primary persistent hyperinsulinemic hypoglycemia of infancy. Arch Endocrinol Metab. 2015;59(5):466-469.  https://doi.org/10.1590/2359-3997000000094
  37. Bjarnesen AP, Dahlin P, Globa E, Petersen H, Brusgaard K, Rasmussen L, Melikian M, Detlefsen S, Christesen HT, Mortensen MB. Intraoperative ultrasound imaging in the surgical treatment of congenital hyperinsulinism: prospective, blinded study. BJS Open. 2021;5;5(2).zraa008  https://doi.org/10.1093/bjsopen/zraa008
  38. Scott Adzick N. Surgical treatment of congenital hyperinsulinism. Semin Pediatr Surg. 2020;29(3):150924. https://doi.org/10.1016/j.sempedsurg.2020.150924
  39. Liem NT, Son TN, Hoan NT. Laparoscopic near-total pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy: report of two cases. J Laparoendosc Adv Surg Tech A. 2010;20(1):115-117.  https://doi.org/10.1089/lap.2008.0316
  40. Richards MK, Clifton MS. Minimally invasive surgery of the pancreas: a narrative review of current practice. Transl Gastroenterol Hepatol. 2021;6:38.  https://doi.org/10.21037/tgh-20-220

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.