Laparoscopic treatment of congenital and acquired diseases of the stomach in newborns and infants is an alternative to surgical treatment of these diseases with laparotomy. The purpose of this study is to compare the groups of patients with open and minimally invasive surgery. Material and methods. It is information about 501 child at the age of 3 months with performed surgery on the stomach. According to the type of operation, all patients were divided into several groups: 1) Nissen fundoplication — 147 patients (laparotomy — 47; laparoscopy — 100); 2) gastrostomy — 86 patients (laparotomy — 26; laparoscopy — 60); 3) pyloromyotomy — 252 patients (laparotomy — 141; laparoscopy — 111); 4) gastrography with perforation of the stomach — 16 patients (laparotomy — 14; laparoscopy — 2). A comparison of the demographic, intraoperative and postoperative parameters of patients took place. Results. Groups had similar demographic and other preoperative parameters. There were significant differences in the duration of the open and laparoscopic procedures. Length of stay in the neonatal intensive care unit and the term of the hospital stay was statistically less after endosurgical interventions. The complication rate was equivalent in the two groups. Conclusion. Laparoscopic treatment of stomach diseases in newborns and infants demonstrates better outcomes than open surgery.