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Korzheva I.Yu.
Russian Medical Academy for Continuous Professional Education;
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Laktyun’kina E.N.
Russian Medical Academy for Continuous Professional Education;
Veresaev Moscow City Clinical Hospital
Syzrantsev A.Yu.
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Evaluating the efficacy of the Kyoto classification of gastritis in diagnosing Helicobacter pylori infection
Journal: Russian Journal of Evidence-Based Gastroenterology. 2025;14(1): 29‑38
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To cite this article:
Korzheva IYu, Laktyun’kina EN, Kozyr’ LV, Syzrantsev AYu. Evaluating the efficacy of the Kyoto classification of gastritis in diagnosing Helicobacter pylori infection. Russian Journal of Evidence-Based Gastroenterology.
2025;14(1):29‑38. (In Russ.)
https://doi.org/10.17116/dokgastro20251401129
Helicobacter pylori infection is a modifiable risk factor for gastric cancer, which is often diagnosed at late stages. The Kyoto classification of gastritis was developed to improve the accuracy of diagnosing H. pylori-associated gastritis and to assess precancerous changes in the gastric mucosa.
Objective: to evaluate the efficacy of the Kyoto classification of gastritis in diagnosing active H. pylori infection.
A retrospective case-control study involving 329 patients (206 women and 123 men) with a median age of 49 years (range 17—85 years) who underwent examination from 2020 to 2024. High-resolution white-light endoscopy and narrow-band imaging modes was used. H. pylori infection was diagnosed using histological examination and a rapid urease test. Statistical analysis included logistic regression and ROC analysis.
Statistically significant endoscopic features of infected mucosa included diffuse hyperemia (OR=255; 95% CI 91.3—937.3), enlarged folds (OR=10.7; 95% CI 3.190—35.906), granularity (OR=17.3; 95% CI 2.3—131.8), and mucosal edema (OR=15.1; 95% CI 8.663—26.445). Non-infected mucosa was characterized by regular arrangement of collecting venules (OR=0.018; 95% CI 0.006—0.060) and their recurrence (OR=0.074; 95% CI 0.035—0.156). The predictive model showed a sensitivity of 92.9% and specificity of 93.2%.
The Kyoto classification of gastritis has proven to be a simple and effective tool for endoscopic diagnosis of H. pylori-associated gastritis. The study results offer new opportunities for clinical practice, facilitating early diagnosis and reducing gastric cancer incidence.
Authors:
Korzheva I.Yu.
Russian Medical Academy for Continuous Professional Education;
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Laktyun’kina E.N.
Russian Medical Academy for Continuous Professional Education;
Veresaev Moscow City Clinical Hospital
Syzrantsev A.Yu.
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Received:
09.10.2024
Accepted:
19.11.2024
List of references:
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