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Bulgakov S.A.

Pirogov Russian National Research Medical University

Opioid peptides in the regulation of eating behavior and appetite. (A Narrative Review)

Authors:

Bulgakov S.A.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2024;13(1): 79‑85

DOI: 10.17116/dokgastro20241301179

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Table of contents

OPIOID PEPTIDES IN THE REGULATION OF EATING BEHAVIOR AND APPETITE. (A NARRATIVE REVIEW)
OPIOID PEPTIDES IN THE REGULATION OF EATING BEHAVIOR AND APPETITE. (A NARRATIVE REVIEW)

To cite this article:

Bulgakov SA. Opioid peptides in the regulation of eating behavior and appetite. (A Narrative Review). Russian Journal of Evidence-Based Gastroenterology. 2024;13(1):79‑85. (In Russ.)
https://doi.org/10.17116/dokgastro20241301179

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

Illuminate the involvement of opioid system peptides in governing eating behavior (EB) and appetite.

KEY POINTS

Insights from various experimental studies suggest that endogenous opioid peptides play a pivotal role in regulating fundamental aspects of the digestive process — EB and appetite. Special focus is placed on endogenous peptides (endorphins and enkephalins), exploring their physiological and pharmacological effects, and their potential impact on diverse pathological conditions and diseases, such as obesity and metabolic disorders. The potential development of novel medicinal products based on synthetic opioid peptides is under consideration.

CONCLUSIONS

Opioid system peptides (enkephalins, endorphins) are vital contributors to the regulation of EB and appetite, offering corrective avenues for disruptions in the feeding process. The exploration of neuropeptides’ and the opioid system’s roles in governing digestion, appetite, and EB should persist and be encouraged, leveraging the capabilities of modern biochemistry and pharmacology to develop innovative medications rooted in opioid peptides.

Keywords:

eating behavior
appetite
obesity
peptides
opioid system

Authors:

Bulgakov S.A.

Pirogov Russian National Research Medical University

Received:

27.11.2023

Accepted:

06.01.2024

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