Cholesterosis of the gallbladder — beyond ultrasound phenomenon

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OBJECTIVE

We reviewed current data on the etiology, epidemiology, pathogenesis, and diagnosis of gallbladder cholesterosis (GC).

MAIN POINTS

Gallbladder cholesterosis (GC) is considered a part of the lipid disorder in its early stages. Risk factors for GC development are atherogenic dyslipidemia, insulin resistance, endothelial dysfunction, and overweight. The scientific community discusses the role of H. pylori as a possible trigger of dyslipidemia and gallbladder wall pathological changes. The polypoid form of the GC is considered a benign lesion, so patients need repeated follow-up examinations and correction of the lipid profile. In the article, we discuss diagnostic methods of the GC, differential diagnosis with malignant lesions, and risk factors for GC complications.

CONCLUSION

GC should be considered as one of the early manifestations of metabolic syndrome. Therefore, assessment of the risk factors of the GC on the first visit and early correction of dyslipidemia reduces cardiovascular complications in this group of patients.

Keywords:

gallbladder diseases

gallbladder cholesterosis

cholesterol polyps

metabolic syndrome

lipid metabolism disorders

Authors:

Girfanova L.G.

Doctor Girfanova’s office

Khlynova O.V.

Vagner Perm State Medical University

Received:

30.03.2021

Accepted:

08.07.2021

List of references:

Il’chenko AA. Bolezni zhelchnogo puzyrya i zhelchnyh putej. Rukovodstvo dlya vrachej. M.: Medicinskoe informacionnoe agentstvo; 2011. (In Russ.).
Lazebnik LB, Ovsannikova ON, Zvenigorodskaya LA, Melnikova NV, Samsonova IG, Khomeriki SG. Cholesterosis of the galldladder and atherogenic dyslipidemia: etiology, pathogenesis, clinical symptoms, diagnosis and treatment. Terapevticheskij arhiv. 2008;8(1):57-61. (In Russ.).
Chernyshov AL, Chelemova EE. Gallbladder cholesterosis (Literature review). Doctor Ru. 2009;1:62-68. (In Russ.).
Mispakhov GB, Akimov VP, Petrova VV. Diagnosis and treatment of gallbladder cholesterosis. Vestnik Sankt-Peterburgskogo universiteta. Medicina. 2011;2:84-85. (In Russ.).
Yaylak F, Deger A, Ucar BI, Sonmez Y, Bayhan Z, Yetisir F. Cholesterolosis in routine histapathological examination after cholecysectomy: What should a surgeon behold in the reports? International Journal of Surgery. 2014;12(11):1187-1191. https://doi.org/10.1016/j.ijsu.2014.08.402
Akyürek N, Salman B, Irkörücü O, Sare M, Tatlicioğlu E. Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature. HPB (Oxford). 2005;7(2):155-158. https://doi.org/10.1080/13651820510003762
Saveliev VS, Petukhov VA, Karalkin AV, Fomin DK. Extragepatic biliary dysfunction in lipid distress-syndrom:etiopathogenesis, diagnosis and principles of treatment. RMJ. 2002;2:62. (In Russ.).
Cherkashina EA. Problems of diagnosis and treatment of gallbladder cholesterosis. Ul’yanovskij mediko-biologicheskij zhurnal. 2015;1:50-59. (In Russ.).
Seon HL, Dong HK, Min JP, YoungSK, Chung HK, JungYY, Kyung RC, Sun SK, Seung HC, Nayoung K,Sang HC, Byung HO. Is metabolic syndrome one of the risk factors of gallbladder polyps found by ultrasonography during health screening? Gut and Liver. 2007;1(2)6138-144. https://doi.org/10.5009/gnl.2007.1.2.138
Bagirov RN, Troshina LA, Chesnocova LN, Medvedeva IV. Vesica fellae cholesterosis is an early marker of atherosclerotic process in patients with metabolic syndrome. Medicinskaya nauka i obrazovanie Urala. 2012;13(1):7-10. (In Russ.).
Matos A, Baptista H, Pinheiro C, Martino F. Gallbladder polip:how should they be treated and when? Revista da Associacao Medica Brasileira. 2010;56(3):318-321. https://doi.org/10.1590/s0104-42302010000300017
Ilchenko AA. Cholesterosis of gallbladder.Patient management tactics and treatment. Trudnyj pacient. 2010;8(6-7):45-50. (In Russ.).
Ovsyanikva ON, Zvenigorodskaya LL, Ilchenko AA. Steatogepatosis and cholesterosis in patients with metabolic syndrome. Eksperimental’naya i klinicheskaya gastroenterologiya. 2006;5:35-39. (In Russ.).
Butorova LI. Holesteroz zhelchnogo puzyrya: patogenez, klinika, diagnostika, principy konservativnoj terapii. Posobie dlya vrachej. M.: Forte print; 2012. (In Russ.).
Ivanchenkova RA, Sviridov AV, Grachev SV. Holesteroz zhelchnogo puzyrya: sovremennyj vzglyad na patogenez, diagnostiku i lechenie. M.: Medinformagentstvo; 2005. (In Russ.).
Ivanchenkova RA, Gatsenko VP, Atkova ER. Possibilities of correction of lipid disorders in patients with gallstone diseases and cholesterosis of the gallbladder. Eksperimental’naya i klinicheskaya gastroenterologiya. 2010:9:81-89. (In Russ.).
Mendez-Sanchez N, Tanimoto MA, Cobos E, Roldan-Valadez E, Uribe M. Cholesterolosis is not associated with high cholesterol levels in patients with and without gallstone disease. Journal of Clinical Gastroenterology. 1997;25(3):518-521. https://doi.org/10.1097/00004836-199710000-00007
Lazebnik LB, Ilchenko AA, Orlova YuN, Khomeriki SG, Silvestrova SYu, Drozdov VN, Lychkova AEh. Sposob diagnostiki holesteroza zhelchnogo puzyrya. Patent RU for invention №RU2276967C2/26.07.2004. Accessed March 20, 2021. https://findpatent.ru/patent/
Tymoshenko GG, Kupina OE, Bogachenko SM, Kutuzova EA. Cholesterosis of the gallbladder. Glannyy vrach yaga Rossii. 2019;65(1):55-56. (In Russ.).
Lee H, Kim K, Park I, Cho H, Gwak G, Yang K, Bae BN, Kim HJ, Kim YD. Preoperative predictive factors for gallbladder cholesterol polyp diagnosed after laparoscopic cholecystectomy for polypoid lesions of gallbladder. Annals of Hepato-biliary-pancreatic Surgery. 2016;20(4):180-186. https://doi.org/10.14701/ahbps.2016.20.4.180
Prakticheskoe rukovodstvo po ul’trazvukovoj diagnostike. Obshchaya ul’trazvukovaya diagnostika. Pod red. Mit’kova V.V. M.: Izdatel’skij dom Vidar-M; 2011. (In Russ.).
Oh SH, Han HY, Kim HJ. Comet tail artifact on ultrasonography: is it a reliable finding of benign gallbladder diseases? Ultrasonography. 2019;38(3):221-230. https://doi.org/10.14366/usg.18029
Nikishina MN, Pimanov SN. Ultrasound diagnostics of gallbladder cholesterosis. Sonoace International. 2004;12:19-24. (In Russ.).
Gallahan WC, Conway JD. Diagnosis and menegment of gallbladder polyps. Gastroenterology Clinics of North America. 2010; 39(2):359-x. https://doi.org/10.1016/j.gtc.2010.02.001
Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clinical Epidemiology. 2014;6:99-109. https://doi.org/10.2147/CLEP.S37357
Velidedeoğlu M, Çitgez B, Arıkan AE, Ayan F. Is it necessary to perfom prophylactic cholecystectomy for all symptomatic gallbladder polyps diagnosed with ultrasound? Turkish Journal of Surgery. 2017;33(1):25-28. https://doi.org/10.5152/UCD.2015.3259
Dong Y, Xu B, Cao Q, Zhang Q, Qio Y, Yu L, Wang W-P. Incidentally detected focal fundal gallbladder wall thickening: Differentiation contrast enhansed ultrasound features with high-resolution linear transducers. Clinical Hemorheology and Microcirculation. 2020;74(3):315-325. https://doi.org/10.3233/CH-190697
McCain RS, Diamond A, Jones C, Coleman GH. Current practices and future prospects for the management of gallbladder polyps: A topical review. World Journal of Gastroenterology. 2018;24(26):2844-2852. https://doi.org/10.3748/wjg.v24.i26.2844
Yu M, Kim Y, Park H, Jung S. Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases. World Journal of Gastroenterology. 2020;26(22):2967-2986. https://doi.org/10.3748/wjg.v26.i22.2967
Sherbinina MB, Zakrevskaya EV, Korolenko AS, Lymar LI. Cholesterosis and chronic cholecystitis: comparative analysis of the state of the gallbladdet wall. Morfologiya. 2007;1(3):94-99. (In Russ.).
Orlova YuN, Ilchenko AA, Checkmazov IA, Chicunova BZ, Chomeriki SG, Morozov IA. Clinicomorphological characterics of the gallbladder cholesterosis based on material from 345 cholecystectomies. Ekperimental’naya i klinicheskaya gastroenterologiya. 2003;6:28-31. (In Russ.).
Gorbatyuk IB. Features of dynamic ultrasonography indicators for gallbladder cholesterol, depending on the body mass index. Colloqium-Journal. 2019;42(18-1):63-66. (In Russ.).
Kim TJ, Lee H, Kang M, Kim JE, Choi YH, Min YW, Min BH, Lee JH, Son HJ, Rhee PL, Baek SY, Ahn SH, Kim JJ. Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease. Scientific Reports. 2016;6:38015. https://doi.org/10.1038/srep38015
Kawaguchi M, Saito T, Ohno H, Midorikawa S, Sanji T, Handa Y, Morita S, Yoshida H, Tsurui M, Misaka R, Hirota T, Saito M, Minami K. Bacteria closely resembling H. pylori detected immunogistologically and genetically in resected gallbladder mucosa. Journal of Gastroenterology. 1996;31(2):294-298. https://doi.org/10.1007/BF02389534
Cen L, Pan J, Zhou B, Yu C, Li Y, Chen W, Shen Z. Helicobacter pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: a systematic review and meta- analysis. Helicobacter. 2018;23(1):10.1111/hel.12457. https://doi.org/10.1111/hel.12457
Ari A, Tatar C, Yarikkaya E. Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies. Journal of International Medical Research. 2019;47(10):4904-4910. https://doi.org/10.1177/0300060519847345
Kanthan R, Senger JL, Ahmed S, Kanthan SC. Cancer in the 21 st Century. Journal of Oncology. 2015;2015:967472. https://doi.org/10.1155/2015/967472
Sabbaghian MS, Ranaudo J, Zeng L, Alongi AP, Perez-Perez G, Shamamian P. Identification of Helicobacter spp. In bile and gallbladder tissue of patients with symptomatic gallbladder disease. HBP. 2010;12(2):129-133. https://doi.org/10.1111/j.1477-2574.2009.00148.x
Choi YS, Do JH, Seo SW, Lee SE, Oh HC, Min YJ, Kang H. Prevalense and risk factors of gallbladder polypoid lesions in a healthy population. Yonsei Medical Journal. 2016;57(6):1370-1375. https://doi.org/10.3349/ymj.2016.57.6.1370
De Armas RE, Rosenberg JM, Fenves AZ. Cholesterolosis, as a cause of acute pancreatitis. Proceedings (Baylor University. Medical Center). 2018;31(3):324-325. https://doi.org/10.1080/08998280.2018.1460128
Parrilla Paricio P, García Olmo D, Pellicer Franco E, Prieto González A, Carrasco González L, Bermejo López J. Gallbladder cholesterolosis: an etiological factor in acute pancreatitis of uncertain origin. British Journal of Surgery. 1990;77(7):735-736. https://doi.org/10.1002/bjs.1800770706
Dairi S, Demeusy A, Sill AM, Patel ST, Kowdley GC, Cunningham SC. Implications of gallbladder cholesterolosis and cholesterol polyps. Journal of the Surgical Research. 2016;200(2):467-472. https://doi.org/10.1016/j.jss.2015.08.037
Roa I, de Aretxabala X, Ibacache G, Muñoz S. Association between cholesterolosis and gallbladder cancer. Revista Medica de Chile. 2010;138(7):804-808. https://doi.org/10.4067/S0034-98872010000700002

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