TRPS1 — новый иммуногистохимический маркер для диагностики рака молочной железы

Авторы:

Сергей Владимирович Вторушин,

Крахмаль Н.В.,

Сергей Сергеевич Наумов

Журнал: Архив патологии. 2026;88(1):80-87.

DOI: 10.17116/patol20268801180

Прочитано: 1133 раза

Резюме

TRPS1 (Tricho-rhino-phalangeal syndrome type 1) — транскрипционный фактор из семейства GATA в последние годы активно изучается как новый иммуногистохимический маркер рака молочной железы. В обзоре представлены современные данные о диагностической, прогностической и потенциальной терапевтической ценности TRPS1, а также сведения о его молекулярной функции и экспрессии в различных подтипах рака молочной железы. Показано, что TRPS1 обладает высокой чувствительностью, включая тройной негативный рак и низкодифференцированные формы карциномы, где традиционные маркеры (GATA3, маммаглобин) могут отсутствовать. Отмечены преимущества TRPS1 при дифференциальной диагностике метастазов и его потенциальная роль в прогностических панелях. В статье обсуждаются ограничения метода с использованием данного маркера, а также перспективы стандартизации и внедрения в клиническую практику.

Ключевые слова

TRPS1
GATA3
рак молочной железы
тройной негативный рак молочной железы
диагностический маркер
метастазы

Дата поступления: 06.08.2025

Дата принятия в печать: 22.10.2025

Дата публикации: 27.01.2026

Литература / References

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TRPS1 — новый иммуногистохимический маркер для диагностики рака молочной железы

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Ключевые слова

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