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Kogan E.A.

Sechenov First Moscow State Medical University

Demura S.A.

I.M. Sechenov First Moscow State Medical University

Afonina M.A.

I.M. Sechenov First Moscow State Medical University

Sarcoid reaction with focal interstitial fibrosis in a COVID-19 patient with persistence of Sars-Cov-2 virus nucleocapsid and adhesion proteins in sarcoid granulomas and lung tissue

Authors:

Kogan E.A., Demura S.A., Afonina M.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(4): 54‑57

DOI: 10.17116/patol20258704154

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Table of contents

SARCOID REACTION WITH FOCAL INTERSTITIAL FIBROSIS IN A COVID-19 PATIENT WITH PERSISTENCE OF SARS-COV-2 VIRUS NUCLEOCAPSID AND ADHESION PROTEINS IN SARCOID GRANULOMAS AND LUNG TISSUE
SARCOID REACTION WITH FOCAL INTERSTITIAL FIBROSIS IN A COVID-19 PATIENT WITH PERSISTENCE OF SARS-COV-2 VIRUS NUCLEOCAPSID AND ADHESION PROTEINS IN SARCOID GRANULOMAS AND LUNG TISSUE

To cite this article:

Kogan EA, Demura SA, Afonina MA. Sarcoid reaction with focal interstitial fibrosis in a COVID-19 patient with persistence of Sars-Cov-2 virus nucleocapsid and adhesion proteins in sarcoid granulomas and lung tissue. Russian Journal of Archive of Pathology. 2025;87(4):54‑57. (In Russ.)
https://doi.org/10.17116/patol20258704154

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

A case report of pulmonary sarcoidosis with fibrosis after COVID-19 is presented. Morphologic and immunohistochemical analysis of lung biopsies for Sars-Cov2 nucleocapsid and adhesion proteins was performed. Virus proteins were detected in alveolar macrophages, second-order pneumocytes and bronchiolar epithelium, also in granuloma-associated macrophages, multinucleated Pirogov-Langhans cells, indicating Sars-Cov2 persistence. Meanwhile, release of pro-inflammatory cytokines by granuloma cells and interstitial macrophages resulted in tissue damage and pulmonary fibrosis.

Keywords:

sarcoidosis
interstitial lung diseases
COVID-19
Sars-Cov2 spike protein
lung fibrosis

Authors:

Kogan E.A.

Sechenov First Moscow State Medical University

Demura S.A.

I.M. Sechenov First Moscow State Medical University

Afonina M.A.

I.M. Sechenov First Moscow State Medical University

Received:

27.01.2025

Accepted:

29.04.2025

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References:

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