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Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Oliushina E.M.

Russian Medical Academy of Continuous Professional Education

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Kuznetsova O.A.

Russian Medical Academy of Continuous Professional Education

Moskvina L.V.

Russian Medical Academy of Continuous Professional Education

Frank G.A.

Russian Medical Academy of Continuous Professional Education

Updated CAP guidelines for determining molecular biological subtypes of breast cancer

Authors:

Zavalishina L.E., Oliushina E.M., Andreeva Yu.Yu., Kuznetsova O.A., Moskvina L.V., Frank G.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2023;85(4): 39‑46

DOI: 10.17116/patol20238504139

Read: 4186 times

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Table of contents

UPDATED CAP GUIDELINES FOR DETERMINING MOLECULAR BIOLOGICAL SUBTYPES OF BREAST CANCER
UPDATED CAP GUIDELINES FOR DETERMINING MOLECULAR BIOLOGICAL SUBTYPES OF BREAST CANCER

To cite this article:

Zavalishina LE, Oliushina EM, Andreeva YuYu, Kuznetsova OA, Moskvina LV, Frank GA. Updated CAP guidelines for determining molecular biological subtypes of breast cancer. Russian Journal of Archive of Pathology. 2023;85(4):39‑46. (In Russ.)
https://doi.org/10.17116/patol20238504139

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Updated 2023 guidelines from the College of American Pathologists (CAP) on immunohistochemical detection of human epidermal growth factor receptor type 2 (HER2), receptors of estrogen (ER) and progesterone (PgR), and the cell proliferation marker Ki-67 in breast cancer are presented. Attention is drawn to the emergence of two new terms «ER Low Positive» and «HER2 Low» to characterize tumors with low expression of estrogen receptors and HER2.

Keywords:

breast cancer
human epidermal growth factor receptor type 2
HER2 expression
ER expression
PgR expression
Ki-67 expression
HER2 Low

Authors:

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Oliushina E.M.

Russian Medical Academy of Continuous Professional Education

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Kuznetsova O.A.

Russian Medical Academy of Continuous Professional Education

Moskvina L.V.

Russian Medical Academy of Continuous Professional Education

Frank G.A.

Russian Medical Academy of Continuous Professional Education

Received:

04.05.2023

Accepted:

19.05.2023

Close metadata

References:

  1. Frank GA, Zavalishina LE, Andreeva YuYu, eds. Breast cancer. Morphological diagnostics and genetics. A guide for doctors. 2nd ed. M.: Prakticheskaya Meditsina; 2021. (In Russ.).
  2. Association of Oncologists of Russia, All-Russian public organization «Russian Society of Clinical Oncology», All-Russian public organization «Russian Society of Oncologists». Clinical guidelines. Breast Cancer. 2021;93. (In Russ.).
  3. National Comprehensive Cancer Network. (NCCN) Clinical Practice Guideline in Oncology. Breast cancer. Version 3.2017. Accessed December 18, 2017. www.nccn.org/professionals/physician_gls/PDF/breast.pdf
  4. Harris L, Fritsche H, Mennel R, Norton L, Ravdin P, Taube S, Somerfield MR, Hayes DF, Bast RC Jr.; American Society of Clinical Oncology. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 2007;25(33):5287-5312. https://doi.org/10.1200/JCO.2007.14.2364
  5. Pusztai L, Viale G, Kelly CM, Hudis CA. Estrogen and HER-2 receptor discordance between primary breast cancer and metastasis. Oncologist. 2010;15(11):1164-1168. https://doi.org/10.1634/theoncologist.2010-0059
  6. Arslan C, Sari E, Aksoy S, Altundag K. Variation in hormone receptor and HER-2 status between primary and metastatic breast cancer: review of the literature. Expert Opin Ther Targets. 2011;15(1):21-30.  https://doi.org/10.1517/14656566.2011.537260
  7. Fitzgibbons PL, Connolly JL. Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast. Version: 15.0.1. College of American Pathologists; 2023;19.  https://documents.cap.org/documents/Breast.Bmk_1.5.0.1.REL_CAPCP.pdf
  8. Allison KH, Hammond MEH, Dowsett M, McKernin SE, Carey LA, Fitzgibbons PL, Hayes DF, Lakhani SR, Chavez-MacGregor M, Perlmutter J, et al. Estrogen and progesterone receptor testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update. Arch Pathol Lab Med. 2020;144(5):545-563.  https://doi.org/10.5858/arpa.2019-0904-SA
  9. Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, et al. Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update. Arch Pathol Lab Med. 2018;142(11):1364-1382. https://doi.org/10.5858/arpa.2018-0902-SA
  10. Arber JM, Arber DA, Jenkins KA, Battifora H. Effect of decalcification and fixation in paraffin-section immunohistochemistry. Appl Immunohistochem. 1996;4:241-248. 
  11. Yaziji H, Taylor CR, Goldstein NS, Dabbs DJ, Hammond EH, Hewlett B, Floyd AD, Barry TS, Martin AW, Badve S, et al.; Members of the Standardization Ad-Hoc Consensus Committee. Consensus recommendations on estrogen receptor testing in breast cancer by immunohistochemistry. Appl Immunohistochem Mol Morphol. 2008;16(6):513-520.  https://doi.org/10.1097/PAI.0b013e31818a9d3a
  12. Allred DC. Problems and solutions in the evaluation of hormone receptors in breast cancer. J Clin Oncol. 2008;26(15):2433-2435. https://doi.org/10.1200/JCO.2007.15.7800
  13. Arber DA. Effect of prolonged formalin fixation on the immunohistochemical reactivity of breast markers. Appl Immunohistochem Mol Morphol. 2002;10(2):183-186.  https://doi.org/10.1097/00129039-200206000-00015
  14. Yildiz-Aktas IZ, Dabbs DJ, Bhargava R. The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma. Mod Pathol. 2012;25(8):1098-1105. https://doi.org/10.1038/modpathol.2012.59
  15. Neumeister VM, Anagnostou V, Siddiqui S, England AM, Zarrella ER, Vassilakopoulou M, Parisi F, Kluger Y, Hicks DG, Rimm DL. Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues. J Natl Cancer Inst. 2012;104(23):1815-1824. https://doi.org/10.1093/jnci/djs438
  16. Harvey JM, Clark GM, Osborne CK, Allred DC. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 1999;17(5):1474-1481. https://doi.org/10.1200/JCO.1999.17.5.1474
  17. Viale G, Regan MM, Maiorano E, Mastropasqua MG, Dell’Orto P, Rasmussen BB, Raffoul J, Neven P, Orosz Z, Braye S, et al. Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98. J Clin Oncol. 2007;25(25):3846-3852. https://doi.org/10.1200/JCO.2007.11.9453
  18. Collins LC, Botero ML, Schnitt SJ. Bimodal frequency distribution of estrogen receptor immunohistochemical staining results in breast cancer: an analysis of 825 cases. Am J Clin Pathol. 2005;123(1):16-20.  https://doi.org/10.1309/hcf035n9wk40etj0
  19. Nadji M, Gomez-Fernandez C, Ganjei-Azar P, Morales AR. Immunohistochemistry of estrogen and progesterone receptors reconsidered: experience with 5,993 breast cancers. Am J Clin Pathol. 2005;123(1):21-27.  https://doi.org/10.1309/4wv79n2ghj3x1841
  20. Selvarajan S, Bay BH, Choo A, Chuah KL, Sivaswaren CR, Tien SL, Wong CY, Tan PH. Effect of fixation period on HER2/neu gene amplification detected by fluorescence in situ hybridization in invasive breast carcinoma. J Histochem Cytochem. 2002;50(12): 1693-1696. https://doi.org/10.1177/002215540205001215
  21. Willmore-Payne C, Metzger K, Layfield LJ. Effects of fixative and fixation protocols on assessment of Her-2/neu oncogene amplification status by fluorescence in situ hybridization. Appl Immunohistochem Mol Morphol. 2007;15(1):84-87.  https://doi.org/10.1097/01.pai.0000209866.20581.8e
  22. Brown RS, Edwards J, Bartlett JW, Jones C, Dogan A. Routine acid decalcification of bone marrow samples can preserve DNA for FISH and CGH studies in metastatic prostate cancer. J Histochem Cytochem. 2002;50(1):113-115.  https://doi.org/10.1177/002215540205000113
  23. Zavalishina LÉ, Andreeva YuYu, Olyushina EM, Moskvina LV, Frank GA. Updated 2018 ASCO/CAP recommendations on the definition of human epidermal growth factor receptor type 2 (HER2) in breast cancer. Arkhiv Patologii. 2019;81(6):82-85. (In Russ.). https://doi.org/10.17116/patol20198106182
  24. Dowsett M, Nielsen TO, A’Hern R, Bartlett J, Coombes RC, Cuzick J, Ellis M, Henry NL, Hugh JC, Lively T, et al.; International Ki-67 in Breast Cancer Working Group. Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group. J Natl Cancer Inst. 2011;103(22): 1656-1664. https://doi.org/10.1093/jnci/djr393
  25. Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel members. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013;24(9):2206-2223. https://doi.org/10.1093/annonc/mdt303
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