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Raskin G.A.

Dr. Berezin Medical Institute;
Saint-Petersburg State University

Mukhina M.S.

Dr. Berezin Medical Institute

Kaurtseva A.S.

Dr. Berezin Medical Institute

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Protasova A.E.

Saint Petersburg State University;
I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia;
OOO «AVA-PETER»;
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology;
V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Orlova R.V.

Saint-Petersburg State University;
Saint Petersburg City Clinical Oncology Dispensary

Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites

Authors:

Raskin G.A., Mukhina M.S., Kaurtseva A.S., Andreeva Yu.Yu., Zavalishina L.E., Protasova A.E., Orlova R.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2023;85(1): 36‑42

DOI: 10.17116/patol20238501136

Read: 10078 times

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Table of contents

MICROSATELLITE INSTABILITY AND DNA MISMATCH REPAIR DEFICIENCY DETECTION IN TUMORS OF VARIOUS SITES
MICROSATELLITE INSTABILITY AND DNA MISMATCH REPAIR DEFICIENCY DETECTION IN TUMORS OF VARIOUS SITES

To cite this article:

Raskin GA, Mukhina MS, Kaurtseva AS, Andreeva YuYu, Zavalishina LE, Protasova AE, Orlova RV. Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites. Russian Journal of Archive of Pathology. 2023;85(1):36‑42. (In Russ.)
https://doi.org/10.17116/patol20238501136

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Microsatellite instability, which is caused by a deficiency in the DNA unpaired nucleotide repair system, is an important pathogenetic event for some tumors. In addition, the detection of this molecular feature becomes an independent prognostic factor in the course of the disease and a predictor for the appointment of therapy with immune checkpoint inhibitors. Immunohistochemistry is a reliable and available method for detecting a deficiency in the DNA mismatch repair system, and it has recommended as a screening for hereditary syndromes associated with microsatellite instability. This article discusses the advantages and disadvantages of this research method from the point of view of the practitioner.

Keywords:

microsatellite instability
mismatch repair system
immunohistochemistry

Authors:

Raskin G.A.

Dr. Berezin Medical Institute;
Saint-Petersburg State University

Mukhina M.S.

Dr. Berezin Medical Institute

Kaurtseva A.S.

Dr. Berezin Medical Institute

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Protasova A.E.

Saint Petersburg State University;
I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia;
OOO «AVA-PETER»;
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology;
V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Orlova R.V.

Saint-Petersburg State University;
Saint Petersburg City Clinical Oncology Dispensary

Received:

12.12.2022

Accepted:

21.12.2022

Close metadata

References:

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  5. Luchini C, Bibeau F, Ligtenberg MJL, Singh N, Nottegar A, Bosse T, Miller R, Riaz N, Douillard JY, Andre F, et al. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. Ann Oncol. 2019;30(8):1232-1243. https://doi.org/10.1093/annonc/mdz116
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  7. Janjigian YY, Sanchez-Vega F, Jonsson P, Chatila WK, Hechtman JF, Ku GY, Riches JC, Tuvy Y, Kundra R, Bouvier N, et al. Genetic predictors of response to systemic therapy in esophagogastric cancer. Cancer Discov. 2018;8(1):49-58.  https://doi.org/10.1158/2159-8290.CD-17-0787
  8. Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017;357(6349):409-413.  https://doi.org/10.1126/science.aan6733
  9. Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, Church DN, Morreau H, Smit VTHBM, van Wezel T, et al. Practical guidance for mismatch repair-deficiency testing in endometrial cancer. Ann Oncol. 2017;28(1):96-102.  https://doi.org/10.1093/annonc/mdw542
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