The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Raskin G.A.

Dr. Berezin Medical Institute;
Saint-Petersburg State University

Mukhina M.S.

Dr. Berezin Medical Institute

Kaurtseva A.S.

Dr. Berezin Medical Institute

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Protasova A.E.

Saint Petersburg State University;
I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia;
OOO «AVA-PETER»;
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology;
V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Orlova R.V.

Saint-Petersburg State University;
Saint Petersburg City Clinical Oncology Dispensary

Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites

Authors:

Raskin G.A., Mukhina M.S., Kaurtseva A.S., Andreeva Yu.Yu., Zavalishina L.E., Protasova A.E., Orlova R.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2023;85(1): 36‑42

DOI: 10.17116/patol20238501136

Views: 5211

Downloaded: 228

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Raskin GA, Mukhina MS, Kaurtseva AS, Andreeva YuYu, Zavalishina LE, Protasova AE, Orlova RV. Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites. Russian Journal of Archive of Pathology. 2023;85(1):36‑42. (In Russ.)
https://doi.org/10.17116/patol20238501136

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Close metadata
Recommended articles:
Clinical and labo­ratory para­meters and pathomorphological features of the lungs in patients who have had COVID-19 viral pneumonia. Russian Journal of Archive of Pathology. 2024;(1):27-35
Lung pathology in children with a long-term novel coro­navirus infe­ction COVID-19. Russian Journal of Archive of Pathology. 2024;(1):36-43
Comparative immu­nohistochemistry study of different anti­bodies clones for dete­ction of breast cancer markers (estrogen rece­ptor, progesterone rece­ptor, HER2/neu, Ki-67). Russian Journal of Archive of Pathology. 2024;(2):14-20
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion. Russian Journal of Archive of Pathology. 2024;(2):37-41
Analysis of the work of the Immu­nohistochemical Quality Control Center of the Russian Medi­cal Academy of Continuous Professional Education of the Mini­stry of Health of Russia in 2023. Russian Journal of Archive of Pathology. 2024;(3):38-45
The role of immu­nohistochemical examination in the differential diagnosis of atypical tumors and carcinomas of para­thyroid glands. Russian Journal of Archive of Pathology. 2024;(4):5-12
Alveolar adenoma of the lung. Russian Journal of Archive of Pathology. 2024;(4):38-41
Clinical and morphological asse­ssment of combined protocol for Radiesse in dilu­tion and hardware techniques in patients with signs of chro­nological skin aging and photoaging of the face and décolleté. Plastic Surgery and Aesthetic Medi­cine. 2024;(2):38-50
Precancers of the oral mucosa: clinic, diagnostics. Stomatology. 2024;(2):5-11
Immu­nohistochemical features and pathogenesis of hype­rextensible eyelids. Plastic Surgery and Aesthetic Medi­cine. 2024;(4):25-33

Microsatellite instability, which is caused by a deficiency in the DNA unpaired nucleotide repair system, is an important pathogenetic event for some tumors. In addition, the detection of this molecular feature becomes an independent prognostic factor in the course of the disease and a predictor for the appointment of therapy with immune checkpoint inhibitors. Immunohistochemistry is a reliable and available method for detecting a deficiency in the DNA mismatch repair system, and it has recommended as a screening for hereditary syndromes associated with microsatellite instability. This article discusses the advantages and disadvantages of this research method from the point of view of the practitioner.

Keywords:

microsatellite instability
mismatch repair system
immunohistochemistry

Authors:

Raskin G.A.

Dr. Berezin Medical Institute;
Saint-Petersburg State University

Mukhina M.S.

Dr. Berezin Medical Institute

Kaurtseva A.S.

Dr. Berezin Medical Institute

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Protasova A.E.

Saint Petersburg State University;
I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia;
OOO «AVA-PETER»;
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology;
V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Orlova R.V.

Saint-Petersburg State University;
Saint Petersburg City Clinical Oncology Dispensary

Received:

12.12.2022

Accepted:

21.12.2022

List of references:

  1. An JY, Kim H, Cheong JH, Hyung WJ, Kim H, Noh SH. Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection. Int J Cancer. 2012;131(2):505-511.  https://doi.org/10.1002/ijc.26399
  2. Smyth EC, Wotherspoon A, Peckitt C, Gonzalez D, Hulkki-Wilson S, Eltahir Z, Fassan M, Rugge M, Valeri N, Okines A, et al. Mismatch repair deficiency, microsatellite instability, and survival: an exploratory analysis of the medical research council adjuvant gastric infusional chemotherapy (MAGIC) trial. JAMA Oncol. 2017;3(9):1197-1203. https://doi.org/10.1001/jamaoncol.2016.6762
  3. Ratti M, Lampis A, Hahne JC, Passalacqua R, Valeri N. Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches. Cell Mol Life Sci. 2018;75(22):4151-4162. https://doi.org/10.1007/s00018-018-2906-9
  4. Lindor NM, Burgart LJ, Leontovich O, Goldberg RM, Cunningham JM, Sargent DJ, Walsh-Vockley C, Petersen GM, Walsh MD, Leggett BA, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002;20(4):1043-1048. https://doi.org/10.1200/JCO.2002.20.4.1043
  5. Luchini C, Bibeau F, Ligtenberg MJL, Singh N, Nottegar A, Bosse T, Miller R, Riaz N, Douillard JY, Andre F, et al. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. Ann Oncol. 2019;30(8):1232-1243. https://doi.org/10.1093/annonc/mdz116
  6. Choi YY, Kim H, Shin SJ, Kim HY, Lee J, Yang HK, Kim WH, Kim YW, Kook MC, Park YK, et al. Microsatellite instability and programmed cell death-ligand 1 expression in stage II/III gastric cancer: post hoc analysis of the CLASSIC randomized controlled study. Ann Surg. 2019;270(2):309-316.  https://doi.org/10.1097/SLA.0000000000002803
  7. Janjigian YY, Sanchez-Vega F, Jonsson P, Chatila WK, Hechtman JF, Ku GY, Riches JC, Tuvy Y, Kundra R, Bouvier N, et al. Genetic predictors of response to systemic therapy in esophagogastric cancer. Cancer Discov. 2018;8(1):49-58.  https://doi.org/10.1158/2159-8290.CD-17-0787
  8. Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017;357(6349):409-413.  https://doi.org/10.1126/science.aan6733
  9. Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, Church DN, Morreau H, Smit VTHBM, van Wezel T, et al. Practical guidance for mismatch repair-deficiency testing in endometrial cancer. Ann Oncol. 2017;28(1):96-102.  https://doi.org/10.1093/annonc/mdw542
  10. Bruegl AS, Ring KL, Daniels M, Fellman BM, Urbauer DL, Broaddus RR. Clinical challenges associated with universal screening for Lynch syndrome-associated endometrial cancer. Cancer Prev Res (Phila). 2017;10(2):108-115.  https://doi.org/10.1158/1940-6207.CAPR-16-0219

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.