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Deev R.V.

I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia

Mavlikeev M.O.

I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia

Plotnikov M.V.

Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan

Gazizov I.M.

Kazan State Medical University of the Ministry of Health of Russia

Maksimov A.V.

Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan

Kiyasov A.P.

Kazan (Volga) Federal University

Pathohistological characteristics of muscles in patients with chronic lower limb ischemia

Authors:

Deev R.V., Mavlikeev M.O., Plotnikov M.V., Gazizov I.M., Maksimov A.V., Kiyasov A.P.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(1): 5‑13

DOI: 10.17116/patol2022840115

Read: 3066 times

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Table of contents

PATHOHISTOLOGICAL CHARACTERISTICS OF MUSCLES IN PATIENTS WITH CHRONIC LOWER LIMB ISCHEMIA
PATHOHISTOLOGICAL CHARACTERISTICS OF MUSCLES IN PATIENTS WITH CHRONIC LOWER LIMB ISCHEMIA

To cite this article:

Deev RV, Mavlikeev MO, Plotnikov MV, Gazizov IM, Maksimov AV, Kiyasov AP. Pathohistological characteristics of muscles in patients with chronic lower limb ischemia. Russian Journal of Archive of Pathology. 2022;84(1):5‑13. (In Russ.)
https://doi.org/10.17116/patol2022840115

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Despite the widespread occurrence of ischemic diseases of the lower extremities, including atherosclerosis and diseases with an autoimmune component of their pathogenesis, the pathohistological signs of damage and concomitant chronic ischemia, compensatory tissue responses as intracellular and cellular regeneration remain out of the field of vision in researchers.

OBJECTIVE

To assess the signs of damage (the extent of necrosis and apoptosis, capillary density (CD)) and regeneration (the cross-sectional muscle fiber area (CSMFA), the proportion of centrinucleated muscle fibers (CNMFs), and that of connective tissue), by using the gastrocnemius medial head biopsy specimens obtained from patients with heterogeneous forms of chronic lower limb obliterating diseases (CLLODs).

SUBJECTS AND METHODS

The investigation included the biopsy specimens obtained from 44 men under 65 years of age (their mean age was 54±9.8 years) with Stage IIB—IV chronic limb ischemia (according to the A.V. Pokrovsky-Fontaine classification) with its history of at least six months. The nosological entities were atherosclerotic lesion in 33 patients (distal atherosclerosis n=13), multistage lesion (n=8), and Leriche’s syndrome (n=12); autoimmune-mediated vascular injury in 11 patients (Buerger’s disease (n=7) and nonspecific aortoarteritis (n=4)). The similar muscle fragments obtained during autopsy from the deceased without obvious signs of cardiovascular system diseases were examined as a control.

RESULTS

It was found that there was a statistically significant difference between the nosological entities, as compared to the control in terms of CD and CSMFA (a decrease), the proportion of CNMFs and that of connective tissue (an increase). No substantial differences were found in the studied parameters between the nosological entities.

CONCLUSION

The findings may suggest the universal mechanism for damage to striated muscle tissue because of circulatory hypoxia, regardless of its etiology and the common character of tissue compensatory-adaptive responses (regeneration).

Keywords:

muscle tissue
ischemia
atherosclerosis
Buerger’s disease
nonspecific aortoarteritis

Authors:

Deev R.V.

I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia

Mavlikeev M.O.

I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia

Plotnikov M.V.

Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan

Gazizov I.M.

Kazan State Medical University of the Ministry of Health of Russia

Maksimov A.V.

Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan

Kiyasov A.P.

Kazan (Volga) Federal University

Received:

30.08.2021

Accepted:

10.11.2021

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