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Gulevskaya T.S.

Research Center of Neurology

Anufriev P.L.

Research Center of Neurology

Evdokimenko A.N.

Research Center of Neurology

Current state of cerebral microangiopathy in hypertension

Authors:

Gulevskaya T.S., Anufriev P.L., Evdokimenko A.N.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2021;83(6): 45‑53

DOI: 10.17116/patol20218306145

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To cite this article:

Gulevskaya TS, Anufriev PL, Evdokimenko AN. Current state of cerebral microangiopathy in hypertension. Russian Journal of Archive of Pathology. 2021;83(6):45‑53. (In Russ.)
https://doi.org/10.17116/patol20218306145

Подписка 2025 (Russian Journal of Archive of Pathology)
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Hypertension is the main cause and the most important risk factor for both acute cerebrovascular accident and chronic progressive cerebrovascular insufficiency that is accompanied by severe neurological and mental disorders even to the extent of developing dementia. They are based on hypertension-induced pathology of the intracerebral arteries and cerebral microvasculature — cerebral microangiopathy that leads to small deep (lacunar) infarcts (SDIs) and diffuse cerebral white matter diseases. This review highlights the morphology, pathogenesis, clinical and neuroimaging diagnosis of hypertensive SDIs, and their differential diagnosis with atherosclerotic SDIs in the historical aspect. It is emphasized that the lacunar state of the brain in hypertension is a predictor of massive cerebral hemorrhages. Special attention is paid to current studies of the morphology and pathogenesis of diffuse changes in white matter and to the role of blood-brain barrier impermeability in the development of progressive leukoencephalopathy.

Keywords:

hypertension
cerebral microangiopathy
small deep (lacunar) infarct
cerebral hemispheric white matter

Authors:

Gulevskaya T.S.

Research Center of Neurology

Anufriev P.L.

Research Center of Neurology

Evdokimenko A.N.

Research Center of Neurology

Received:

22.06.2021

Accepted:

17.09.2021

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