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Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovtsev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Sokolova T.V.

Medical Institute of Continuing Education of the Federal State Budgetary Institution of Higher Education «Moscow State University of Food Production»

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Morphological evaluation of the effectiveness of fluorescence navigation with chlorin e6 in surgery for malignant gliomas

Authors:

Rynda A.Yu., Zabrodskaya Yu.M., Olyushin V.E., Rostovtsev D.M., Sokolova T.V., Papayan G.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2021;83(5): 13‑20

DOI: 10.17116/patol20218305113

Views: 2964

Downloaded: 115

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Table of contents

To cite this article:

Rynda AYu, Zabrodskaya YuM, Olyushin VE, Rostovtsev DM, Sokolova TV, Papayan GV. Morphological evaluation of the effectiveness of fluorescence navigation with chlorin e6 in surgery for malignant gliomas. Russian Journal of Archive of Pathology. 2021;83(5):13‑20. (In Russ.)
https://doi.org/10.17116/patol20218305113

Подписка 2025 (Russian Journal of Archive of Pathology)
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OBJECTIVE

To evaluate the effectiveness of fluorescence navigation with chlorin e6 in surgery for malignant gliomas based on surgical material morphological and immunohistochemical data.

MATERIAL AND METHODS

The surgical material obtained from patients with high-grade (Grade III—IV) anaplastic glioma was examined. Along with histological examination, the proliferation marker Ki-67, the cell cycle transcription factor protein p53, and vascular endothelial growth factor (VEGF) were determined.

RESULTS

A significant direct correlation was found between the expression of Ki-67, p53, and VEGF and the fluorescence intensity of tumor tissues (p<0.05).

CONCLUSION

The technique of fluorescence navigation using chlorin e6 in comparative morphopathological analysis has confirmed its effectiveness in surgery for malignant gliomas.

Keywords:

glioma
fluorescence navigation
chlorin e6
neurooncology
immunohistochemistry

Authors:

Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovtsev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Sokolova T.V.

Medical Institute of Continuing Education of the Federal State Budgetary Institution of Higher Education «Moscow State University of Food Production»

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Received:

15.04.2021

Accepted:

28.06.2021

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