Organ changes found by postmortem examination in COVID-19 patients

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The postmortem study results presented in 20 sources of literature on 186 COVID-19 patients were analyzed. Pathological changes were noted in multiple organs, by involving predominantly the respiratory, circulatory, and excretory systems. The changes in the lungs were characterized by an increase in organ weight (59.3%), a dark red color of the parenchyma (47.4%), compaction of lung tissue (56%), and signs of lung congestion (37.3%). The histological characteristics found during postmortem lung tissue examination, which were indicative of diffuse alveolar damage, were proliferation of type II alveolocytes in 65.2% of cases, the appearance of hyaline membranes lining the alveoli in 64.4%, and interstitial edema in 54.2%. In the analyzed sources, 22% of cases were noticed to have severe thrombosis and pulmonary artery branch embolism that was associated with lower extremity deep vein thrombosis. In all the sources of literature, acute tubular necrosis, tubular luminal dilatation, and interstitial edema were detected in the kidneys.

Keywords:

SARS-CoV-2

COVID-19

acute respiratory distress syndrome

diffuse alveolar damage

Authors:

Odilov A.A.

Peoples’ Friendship University of Russia

Tsimbalist N.S.

Peoples’ Friendship University of Russia

Volkov A.V.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-1873-0189

Babichenko I.I.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0001-5512-6813

Received:

05.07.2020

Accepted:

16.09.2020

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