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Oliushina E.M.

Russian Medical Academy of Continuous Professional Education

Byakhova M.M.

Russian Medical Academy for Continuous Professional Education;
Vladimirsky Moscow Regional Research Clinical Institute

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Semenova A.B.

City Clinical Oncology Hospital No. 1

Frank G.A.

Russian Medical Academy of Continuous Professional Education

The role of the immunohistochemical marker p40 in the differential diagnosis of adenocarcinoma and nonkeratinizing squamous cell cancer of the lung

Authors:

Oliushina E.M., Byakhova M.M., Zavalishina L.E., Andreeva Yu.Yu., Semenova A.B., Frank G.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2020;82(5): 50‑56

DOI: 10.17116/patol20208205150

Views: 11877

Downloaded: 365

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To cite this article:

Oliushina EM, Byakhova MM, Zavalishina LE, Andreeva YuYu, Semenova AB, Frank GA. The role of the immunohistochemical marker p40 in the differential diagnosis of adenocarcinoma and nonkeratinizing squamous cell cancer of the lung. Russian Journal of Archive of Pathology. 2020;82(5):50‑56. (In Russ.)
https://doi.org/10.17116/patol20208205150

Подписка 2025 (Russian Journal of Archive of Pathology)
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Lung cancer is one of the main causes of cancer death. It is a heterogeneous group of malignant neoplasms, the treatment tactics for which directly depends on tumor morphology and genetic characteristics. However, the pathomorphological differential diagnosis of adenocarcinoma and squamous cell cancer of the lung is difficult in some cases and an immunohistochemical (IHC) study is needed to verify these tumors; moreover, the IHC panel should include both squamous cell and pneumocyte markers. Fifty surgical and biopsy specimens underwent morphological and IHC studies using antibodies against p40, p63, CK5/6, CK7, and TTF1. In this investigation, p40 showed a higher specificity than another squamous cell differentiation marker, such as p63; this confirms the data that it is advisable to use the marker p40 to verify squamous cell lung carcinoma. If there is a small amount of material for an IHC study in the differential diagnosis of adenocarcinoma from squamous cell cancer of the lung, the optimal solution is to limit the IHC panel to two markers, such as p40 and TTF1.

Keywords:

lung cancer
lung adenocarcinoma
nonkeratinizing squamous cell lung cancer
p40 expression

Authors:

Oliushina E.M.

Russian Medical Academy of Continuous Professional Education

Byakhova M.M.

Russian Medical Academy for Continuous Professional Education;
Vladimirsky Moscow Regional Research Clinical Institute

Zavalishina L.E.

Russian Medical Academy of Continuous Professional Education

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Semenova A.B.

City Clinical Oncology Hospital No. 1

Frank G.A.

Russian Medical Academy of Continuous Professional Education

Received:

12.05.2020

Accepted:

19.06.2020

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