Features of morphology of articular cartilage in patients with different phenotypes of knee osteoarthritis

Korochina K.V.

Orenburg State Medical University

Chernysheva T.V.

Orenburg State Medical University

Polyakova V.S.

Orenburg State Medical University

Korochina I.E.

Orenburg State Medical University

Features of morphology of articular cartilage in patients with different phenotypes of knee osteoarthritis

Authors:

Korochina K.V., Chernysheva T.V., Polyakova V.S., Korochina I.E.

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Journal: Russian Journal of Archive of Pathology. 2020;82(4): 13‑18

DOI: 10.17116/patol20208204113

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To cite this article:

Korochina KV, Chernysheva TV, Polyakova VS, Korochina IE. Features of morphology of articular cartilage in patients with different phenotypes of knee osteoarthritis. Russian Journal of Archive of Pathology. 2020;82(4):13‑18. (In Russ.)
https://doi.org/10.17116/patol20208204113

Подписка 2025 (Russian Journal of Archive of Pathology)

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AIM OF STUDY

To identify structural and functional features of articular cartilage of patients with age-related, post-traumatic, metabolic and mixed phenotypes of knee joints osteoarthritis (OA).

MATERIALS AND METHODS

The articular cartilage (AC) of medial condyle of the knee joint tibia was studied in 40 patients with stage III—IV gonarthrosis of age-related, post-traumatic, metabolic and mixed phenotypes (n=10) using histochemical, morphometric, and statistical methods.

RESULTS

AC of patients with an age-related OA phenotype was characterized by deep fissures, exposure of the subchondral bone, hypocellularity, and a sharp decrease in the content of proteoglycans. Post-traumatic OA was characterized by uneven surface defects, fibrous cartilage replacement, and chondrocyte clustering. With a metabolic phenotype, pronounced vascularization and ossification of cartilage was observed. The mixed phenotype of OA had a heterogeneous structure.

CONCLUSIONS

The morphological basis of various OA phenotypes was studied. The most pronounced degenerative changes in AC were identified with an age-related phenotype; preservation of the regenerative potency of cartilage was found in post-traumatic OA; involvement of the subchondral bone with metabolic phenotype was noted; variable morphological picture of AC was obtained in patients with OA of mixed genesis.

Keywords:

morphology

cartilage

osteoarthritis

phenotype

knee joint

Authors:

Korochina K.V.

Orenburg State Medical University

Chernysheva T.V.

Orenburg State Medical University

Polyakova V.S.

Orenburg State Medical University

Korochina I.E.

Orenburg State Medical University

Received:

05.02.2020

Accepted:

20.04.2020

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